84907-55-1 (1,2-二(4&#x27;-甲酰基苯基)乙炔,2PE)

_98%

反应条件：

1.1 Catalysts: (T-4)-Tris[N-(1,1-dimethylethyl)-3,5-dimethylbenzenaminato]propylidynemolybdenum , Phenol, 2-[3-[2-hydroxy-3-(1-methylethyl)phenyl]-2-[[2-hydroxy-3-(1-methylethyl)… Solvents: Carbon tetrachloride ; 30 min, rt
1.2 Solvents: Carbon tetrachloride ; 2 h, 40 °C

参考文献：

Highly Active Multidentate Ligand-Based Alkyne Metathesis Catalysts

Du, Ya; Yang, Haishen; Zhu, Chengpu; Ortiz, Michael; Okochi, Kenji D.; et al, Chemistry - A European Journal, 2016, 22(23), 7959-7963

合成路线：1 步

471-25-0

_97%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: 1,4-Bis(diphenylphosphino)butane , Dichlorobis(triphenylphosphine)palladium Solvents: Dimethyl sulfoxide ; 1.5 h, 80 °C
1.2 Reagents: Ammonium chloride Solvents: Water ; rt

参考文献：

Synthesis of Symmetrical and Unsymmetrical Diarylalkynes from Propiolic Acid Using Palladium-Catalyzed Decarboxylative Coupling

Park, Kyungho; Bae, Goun; Moon, Jeongju; Choe, Jaehoon; Song, Kwang Ho; et al, Journal of Organic Chemistry, 2010, 75(18), 6244-6251

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: (T-4)-Tris[N-(1,1-dimethylethyl)-3,5-dimethylbenzenaminato]propylidynemolybdenum , 2630900-25-1 Solvents: Carbon tetrachloride ; 10 min, 70 °C
1.2 Solvents: Carbon tetrachloride ; 20 min, 70 °C

参考文献：

Highly active alkyne metathesis catalysts operating under open air condition

Ge, Yanqing; Huang, Shaofeng ; Hu, Yiming ; Zhang, Lei; He, Ling; et al, Nature Communications, 2021, 12(1),

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: (T-4)-Tris[N-(1,1-dimethylethyl)-3,5-dimethylbenzenaminato]propylidynemolybdenum , 2,2′,2′′-[(Methylsilylidyne)tris(methylene)]tris[6-(1-methylethyl)phenol] Solvents: Carbon tetrachloride ; 5 min, rt
1.2 16 h, 40 °C

参考文献：

Multidentate Triphenolsilane-Based Alkyne Metathesis Catalysts

Yang, Haishen; Liu, Zhenning; Zhang, Wei, Advanced Synthesis & Catalysis, 2013, 355(5), 885-890

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Diphenylmethane Catalysts: Rhenium, bis[2-[bis[4-(trifluoromethyl)phenyl]phosphino-κP]phenolato-κO](2-pheny… Solvents: Toluene ; 5 min, rt; 8 h, 100 °C

参考文献：

Alkyne Metathesis with d2 Re(V) Alkylidyne Complexes Supported by Phosphino-Phenolates: Ligand Effect on Catalytic Activity and Applications in Ring-Closing Alkyne Metathesis

Cui, Mingxu; Sung, Herman H. Y.; Williams, Ian D.; Jia, Guochen, Journal of the American Chemical Society, 2022, 144(14), 6349-6360

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Rhenium, bis[2-[bis[3,5-bis(trifluoromethyl)phenyl]phosphino-κP]phenolato-κO](2-… Solvents: Toluene ; 16 h, 100 °C

参考文献：

Robust Alkyne Metathesis Catalyzed by Air Stable d2 Re(V) Alkylidyne Complexes

Cui, Mingxu; Bai, Wei ; Sung, Herman H. Y.; Williams, Ian D.; Jia, Guochen, Journal of the American Chemical Society, 2020, 142(31), 13339-13344

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium ; 24 h, reflux

参考文献：

High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis

Greenaway, R. L.; Santolini, V.; Bennison, M. J.; Alston, B. M.; Pugh, C. J.; et al, Nature Communications, 2018, 9(1), 1-11

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine , Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide ; 12 h, rt → 70 °C

参考文献：

Interacting networks of purely organic spin-1/2 dimers

Borozdina, Yulia B.; Mostovich, Evgeny; Enkelmann, Volker; Wolf, Bernd; Cong, Pham T.; et al, Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 2014, 2(32), 6618-6629

合成路线：1 步

77123-57-0

_88%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; overnight, rt → 85 °C

参考文献：

Synchronized Offset Stacking: A Concept for Growing Large-Domain and Highly Crystalline 2D Covalent Organic Frameworks

Auras, Florian ; Ascherl, Laura; Hakimioun, Amir H.; Margraf, Johannes T.; Hanusch, Fabian C.; et al, Journal of the American Chemical Society, 2016, 138(51), 16703-16710

合成路线：1 步

15164-44-0

75-20-7

_87%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine , Palladium diacetate , Cuprous iodide Solvents: Acetonitrile ; 12 h, rt

参考文献：

Efficient synthesis of diaryl ethynes via palladium-catalyzed coupling of calcium carbide with aryl iodides

Wacharasindhu, Sumrit; Chuentragool, Padon; Vongnam, Kanika; Rashatasakhon, Paitoon; Sukwattanasinitt, Mongkol, Asahi Garasu Zaidan Josei Kenkyu Seika Hokoku, 2013, 1, 1-10

合成路线：1 步

15164-44-0

75-20-7

_87%

反应条件：

1.1 Catalysts: Triphenylphosphine , Palladium diacetate , Cuprous iodide Solvents: Acetonitrile ; 20 min, rt
1.2 Reagents: Triethylamine ; 10 - 12 h, rt

参考文献：

Calcium carbide as a cost-effective starting material for symmetrical diarylethynes via Pd-catalyzed coupling reaction

Chuentragool, Padon; Vongnam, Kunnigar; Rashatasakhon, Paitoon; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit, Tetrahedron, 2011, 67(42), 8177-8182

合成路线：1 步

652974-14-6

_83%

反应条件：

1.1 Catalysts: 4-Nitrophenol , (T-4)-Tris[N-(1,1-dimethylethyl)-3,5-dimethylbenzenaminato]propylidynemolybdenum Solvents: 1,2,4-Trichlorobenzene ; 22 h, 1 mm Hg, 30 °C

参考文献：

Highly Active Trialkoxymolybdenum(VI) Alkylidyne Catalysts Synthesized by a Reductive Recycle Strategy

Zhang, Wei; Kraft, Stefan; Moore, Jeffrey S., Journal of the American Chemical Society, 2004, 126(1), 329-335

合成路线：1 步

_80%

反应条件：

1.1 Catalysts: (T-4)-Tris[N-(1,1-dimethylethyl)-3,5-dimethylbenzenaminato]propylidynemolybdenum , Benzenemethanaminium, 2-hydroxy-N,N-bis[(2-hydroxyphenyl)methyl]-N-methyl-, iodi… Solvents: Carbon tetrachloride ; 2 - 4 min
1.2 9 - 13 h, 40 °C

参考文献：

Highly Active Multidentate Alkyne Metathesis Catalysts: Ligand-Activity Relationship and Their Applications in Efficient Synthesis of Porphyrin-Based Aryleneethynylene Polymers

Jyothish, Kuthanapillil; Wang, Qi; Zhang, Wei, Advanced Synthesis & Catalysis, 2012, 354(11-12), 2073-2078

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; 44 h, 85 °C

参考文献：

Expanded Cyclotetrabenzoins

Eisterhold, Andrew M.; Puangsamlee, Thamon; Otterbach, Steffen; Brase, Stefan; Weis, Patrick ; et al, Organic Letters, 2021, 23(3), 781-785

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; 44 h, rt → 85 °C

参考文献：

Expanded cyclotetrabenzoins

Eisterhold, Andrew M.; Otterbach, Steffen; Brase, Stefan; Weis, Patrick; Wang, Xiqu; et al, ChemRxiv, 2020, 1, 1-4

合成路线：1 步

_71%