863453-61-6 ((R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide,(r)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide)

快速询单

结构式：

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxideMOL文件

CAS号：

863453-61-6

中文名称：

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

英文名称：

(r)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

分子式：

C₈H₁₅NO₅S

分子量：

237.273401498795

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)名称与标识符

名称

中文别名：

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide;(R)-5-甲基-1,2,3-氧杂噻唑烷-3-羧酸叔丁酯 2,2-二氧化物;瑞波替尼中间体;

英文别名：

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide;(5R)-2,2-Dioxido-5-methyl-1,2,3-oxathiazolidine, N-boc protected;ZGFOJWQAHCHOLG-ZCFIWIBFSA-N;FCH3528821;SB18565;AK171416;OR400344;tert-Butyl (5R)-5-methyl-2,2-dioxo-oxathiazolidine-3-carboxylate;(R)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester;1,2,3-Oxathiazolidine-3-carboxylic acid, 5-methyl-, 1,1-dimethylet;863453-61-6;DTXSID301117302;tert-butyl (5R)-5-methyl-2,2-dioxooxathiazolidine-3-carboxylate;AKOS025289819;MFCD27999446;P14515;tert-butyl (5R)-5-methyl-2,2-dioxo-1,2lambda6,3-oxathiazolidine-3-carboxylate;AS-52160;1,2,3-Oxathiazolidine-3-carboxylic acid, 5-methyl-, 1,1-dimethylethylester, 2,2-dioxide, (5R)-;DB-389055;1,2,3-Oxathiazolidine-3-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester, 2,2-dioxide, (5R)-;EN300-6479354;(r)-tert-butyl5-methyl-1,2,3-oxathiazolidine-3-carboxylate2,2-dioxide;TERT-BUTYL (5R)-5-METHYL-2,2-DIOXO-1,2??,3-OXATHIAZOLIDINE-3-CARBOXYLATE;tert-butyl (R)-5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide;CS-0053087;SCHEMBL2980172;

标识符

MDL：

MFCD27999446

InChIKey：

ZGFOJWQAHCHOLG-ZCFIWIBFSA-N

Inchi：

1S/C8H15NO5S/c1-6-5-9(15(11,12)14-6)7(10)13-8(2,3)4/h6H,5H2,1-4H3/t6-/m1/s1

SMILES：

C(N1C[C@@H](C)OS1(=O)=O)(=O)OC(C)(C)C

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)物化性质

计算特性

精确分子量 : 237.06709375g/mol
氢键供体数量 : 0
氢键受体数量 : 5
可旋转化学键数量 : 2
同位素质量 : 237.06709375g/mol
重原子数量 : 15
复杂度 : 350
同位素原子数量 : 0
确定原子立构中心数量 : 1
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 0.9
拓扑分子极性表面积 : 81.3

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)推荐厂家更多厂家(13)

公司名称	手机号/电话	联系人	QQ	询单
上海吉至生化科技有限公司	18117592386 021-57481218	吉至试剂	3007522982	询单
上海源叶生物科技有限公司	15026964105 15026964105	汤思磊	2881489226	询单
上海吉至生化科技有限公司	18117592386 021-57481218	吉至试剂	3007522982	询单
上海吉至生化科技有限公司	18117592386 021-57481218	吉至试剂	3007522982	询单
上海绩祥生物科技有限公司	18605105771	李经理	1799924424	询单
上海腾准生物科技有限公司	19821570922 021-34053661	张经理	3003871136	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
上海甄准生物科技有限公司	15800340161 021-68920155	李经理	3001010259	询单
广州济成进出口贸易有限公司	13682223272	黄刚	173901442	询单
江苏艾康生物医药研发有限公司	18795912720 025-66061636	杨情情	3004779232	询单

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)合成路线

合成路线：1 步

1933711-46-6

_61%

863453-61-6

反应条件：

1.1 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Acetonitrile , Water ; 0 °C; 0 °C → rt; 1 h, rt

参考文献：

Pyrazolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: design, synthesis and biological evaluation

Fan, Yiqing ; et al, Bioorganic & Medicinal Chemistry Letters, 2022, 63,

合成路线：1 步

119768-44-4

_84%

863453-61-6

反应条件：

1.1 Reagents: Imidazole , Thionyl chloride Solvents: Dichloromethane ; 0 - 5 °C; 15 min, 0 - 5 °C; rt; rt → -10 °C
1.2 Solvents: Dichloromethane ; 30 min, -10 °C; 2 h, rt
1.3 Reagents: Sodium periodate Catalysts: Ruthenium dioxide Solvents: Dichloromethane ; 2 h, 0 °C; 2 h, rt

参考文献：

Ring opening of cyclic sulfamidates with bromophenyl metal reagents: complementarity of sulfamidates and aziridines

Hebeisen, Paul; et al, Tetrahedron Letters, 2011, 52(41), 5229-5233

合成路线：2 步

24424-99-5

2799-16-8

863453-61-6

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Potassium carbonate Solvents: Water ; 2 h, rt
2.1 Reagents: Triethylamine , Imidazole , Thionyl chloride Solvents: Dichloromethane ; -60 °C; 3 h, -60 °C; overnight, rt
2.2 Reagents: Water ; rt
2.3 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Acetonitrile , Water ; 4 h, 0 °C

参考文献：

Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase

Zhang, Rong; et al, Chemistry - A European Journal, 2019, 25(27), 6831-6839

合成路线：3 步

24424-99-5

2799-16-8

863453-61-6

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; overnight, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; pH 8
2.1 Reagents: Triethylamine , Imidazole , Thionyl chloride Solvents: Dichloromethane ; -60 °C; 3 h, -60 °C; -60 °C → rt; overnight, rt
3.1 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Acetonitrile , Water ; 0 °C; 0 °C → rt; 1 h, rt

参考文献：

Pyrazolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: design, synthesis and biological evaluation

Fan, Yiqing ; et al, Bioorganic & Medicinal Chemistry Letters, 2022, 63,

81246-81-3(5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-O-[(叔丁基)二甲基硅烷基]尿苷) 80791-88-4(3'-甲氧基-2-氨基腺苷) 80808-96-4(1,5-二甲基-3,7-二氮杂双环3.3.1壬-9-酮) 80912-60-3(4-(1,3-苯并二氧代l-5-基)-1-环己酮) 80959-18-8(2,5-DICHLOROBENZALDEHYDE) 811842-57-6(2'-(Trifluoromethyl)-4-biphenylamine hydrochloride (1:1)) 799262-09-2(4-羟基-5-氟-2H-色烯-2-酮) 79944-65-3(1-Chloro-3-(chloromethyl)-5-fluorobenzene)

问答

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863453-61-6 ((R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide,(r)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide)

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)名称与标识符

名称

标识符

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)物化性质

计算特性

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)推荐厂家 更多厂家(13)

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)合成路线

目录

(R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide(863453-61-6)推荐厂家更多厂家(13)