87512-31-0 ((S)-2-((S)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)丙酰氨基)丙酸,Fmoc-Ala-Ala-OH)

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Chloroform ; 7 h, rt

参考文献：

Two-Fold Odd-Even Effect in Self-Assembled Nanowires from Oligopeptide-Polymer-Substituted Perylene Bisimides

Marty, Roman; et al, Journal of the American Chemical Society, 2014, 136(10), 3919-3927

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Piperidine Solvents: Dimethylformamide ; 30 min, rt
1.2 Reagents: Triethyl phosphite , 2-(1-Methylethyl)-5-nitro-1,2-benzisothiazol-3(2H)-one Catalysts: Copper(2+), tetrakis(1-methylimidazole)-, diiodide Solvents: Dimethylformamide ; 30 min, rt
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 30 min, rt

参考文献：

Benzoisothiazolone (BIT): A fast, efficient, and recyclable redox reagent for solid phase peptide synthesis

Bukya, Hemalatha; et al, European Journal of Organic Chemistry, 2020, 2020(33), 5358-5362

合成路线：1 步

86060-86-8

_90%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; 30 s

参考文献：

Microwave irradiated high-speed solution synthesis of peptide acids employing Fmoc-amino acid pentafluorophenyl esters as coupling agents

Babu, Vommina V. Suresh; et al, Indian Journal of Chemistry, 2005, (11), 2328-2332

合成路线：1 步

_65%

反应条件：

1.1 Reagents: N-Hydroxysuccinimide Solvents: Dimethyl acetal ; rt → 4 °C
1.2 Reagents: Dicyclohexylcarbodiimide ; 24 h, 4 °C
1.3 Reagents: Sodium carbonate Solvents: Ethanol , Acetone , Water ; 20 min, rt

参考文献：

Supramolecular Hydrogels Respond to Ligand-Receptor Interaction

Zhang, Yan; et al, Journal of the American Chemical Society, 2003, 125(45), 13680-13681

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ; 14 min, rt; 2.5 h, rt
1.2 Reagents: Diisopropylethylamine Solvents: Methanol , Dichloromethane ; 30 min, rt
1.3 Reagents: Piperidine Solvents: Dimethylformamide ; 10 min, rt
1.4 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 4 h, rt
1.5 Reagents: 2,2,2-Trifluoroethanol Solvents: Dichloromethane ; 2 h, rt

参考文献：

Alaninyl variants of the marine natural product halocyamine A and their antibacterial properties

Fong, Hugo K. H.; et al, Tetrahedron, 2018, 74(48), 6929-6938

合成路线：1 步

2055227-51-3

反应条件：

1.1 Reagents: Tris(trimethylsilyl)silane Catalysts: Trimethyl phosphite , 1,1′-Azobis(cyclohexane-1-carbonitrile) Solvents: Acetonitrile , Water ; 12 h, 88 °C

参考文献：

Metal-free reductive desulfurization of C-sp3-substituted thiols using phosphite catalysis

Morsy, Rana M. I.; et al, Chemical Science, 2023, 14(34), 9016-9023

合成路线：1 步

反应条件：

1.1 Reagents: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride Solvents: Acetonitrile , Water ; 3 h, pH 9.32, rt

参考文献：

Solution-phase fmoc-based peptide synthesis for DNA-encoded chemical libraries: Reaction conditions, protecting group strategies, and pitfalls

Monty, Olivier B. C.; et al, ACS Combinatorial Science, 2020, 22(12), 833-843

合成路线：1 步

反应条件：

1.1 Reagents: Diisopropylcarbodiimide , HOAt Solvents: Dimethylformamide ; overnight, rt

参考文献：

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery

Zaiter, Samantha S.; et al, Journal of Medicinal Chemistry, 2019, 62(2), 742-761

合成路线：1 步

反应条件：

1.1 Reagents: Diisopropylcarbodiimide , 1-Hydroxybenzotriazole
1.2 Reagents: Piperidine Solvents: Dimethylformamide
1.3 Reagents: Diisopropylcarbodiimide , 1-Hydroxybenzotriazole , N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine
1.4 Reagents: Trifluoroacetic acid , Triisopropylsilane Solvents: Water

参考文献：

N-Aminoacyl and N-hydroxyacyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside: synthesis, antimicrobial and hemolytic activities

Grzywacz, Daria; et al, Bioorganic & Medicinal Chemistry, 2019, 27(20),

合成路线：2 步

13404-22-3