877400-66-3 (3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺,3-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-pyridinamine)

快速询单

结构式：

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺MOL文件

CAS号：

877400-66-3

中文名称：

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺

英文名称：

3-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-pyridinamine

分子式：

C₂₁H₂₂Cl₂FN₅O

分子量：

450.336685657501

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)名称与标识符

名称

中文别名：

3-[1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶基)-1H-吡唑-4-基]-2-吡啶胺;3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;

英文别名：

3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;2-Pyridinamine,3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine :;3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;2-PYRIDINAMINE,3-[1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-[1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YL];3-(1-(2,6-dichloro-3-fluoro-phenyl)ethoxy)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-amine;BOCCHEM BC-L-Y016;Kinome_3143;Kinome_3144;Kinome_3145;rac-crizotinib;3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine;CHEBI:77562;CERAPP_50119;CHEBI:77563;AKOS015842007;HMS3265F12;3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a);HMS3654A15;HMS3265E12;(S)-3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE;racemic crizotinib;3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;FT-0682537;HMS3653B11;PF 2341066;(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;2-PYRIDINAMINE, 3-[1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-[1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YL]-;DTXSID10469200;FT-0665224;HMS3265E11;AB01566339_02;3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;SW220066-1;HMS3265F11;HMS3749G05;PB11015;rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine;(+-)-crizotinib;BCP01745;3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine;3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine;KTEIFNKAUNYNJU-UHFFFAOYSA-N;3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;PF2341066;877400-66-3;BDBM179803;CHEMBL1825138;(RS)-crizotinib;AM808015;DTXSID30870379;SCHEMBL94020;Crizotinib;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;(R,S)-Crizotinib;DB-077095;Xalkori;Crizotinib, (R,S)-;SGP54RX3KH;NS00004964;BRD-A75349800-001-01-8;

标识符

MDL：

MFCD14708244

InChIKey：

KTEIFNKAUNYNJU-UHFFFAOYSA-N

Inchi：

1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)

SMILES：

ClC1C(=CC=C(C=1C(C)OC1=C(N)N=CC(=C1)C1C=NN(C=1)C1CCNCC1)Cl)F

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)物化性质

实验特性

LogP : 5.94770
PSA : 77.99000
沸点 : 599.2±50.0 °C at 760 mmHg
熔点 : NA
蒸气压 : 0.0±1.7 mmHg at 25°C
闪点 : 316.2±30.1 °C
密度 : 1.5±0.1 g/cm3

计算特性

精确分子量 : 449.11900
氢键供体数量 : 2
氢键受体数量 : 6
可旋转化学键数量 : 5
同位素质量 : 449.1185439g/mol
重原子数量 : 30
复杂度 : 558
同位素原子数量 : 0
确定原子立构中心数量 : 0
不确定原子立构中心数量 : 1
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 3.7
拓扑分子极性表面积 : 78Å²

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)安全信息

安全说明： H303+H313+H333
危害声明：H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
警示性声明：P264+P280+P305+P351+P338+P337+P313
储存条件： storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
信号词： warning
HazardClass： IRRITANT

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)海关数据

海关编码：

2933990090

海关数据：

中国海关编码：

2933990090

概述：

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

Summary：

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)推荐厂家更多厂家(7)

公司名称	手机号/电话	联系人	QQ	询单
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3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)上下游

消旋F038 1-(2,5二氯苯基)乙醇 3-(1-(2,6-二氯-3-氟苯基)乙氧基)吡啶-2-胺 3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-AMINE

3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)相关文献

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3-[1-(2,6-二氯-5-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺(877400-66-3)参考资料

Reaxys RN：

PubChem CID：

11597571

1374356-45-2(2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-) 822-28-6(1-(乙烯基氧基)十六烷) 82291-36-9(1,2,4,6,9-PCDD) 82219-47-4(1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-hydroxyethyl) ester) 822-24-2(正二十醋酸) 819066-35-8(3-(ISOQUINOLIN-4-YL)PROPANOIC ACID) 819070-53-6((4-CHLORO-2-CYANOPHENYL)BORONIC ACID) 82304-66-3(7,9-二叔丁基-1-氧杂螺[4.5]癸-6,9-二烯-2,8-二酮)

问答

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