88241-65-0 (香豆素 6,(2E)-3-{1,1&#x27;-biphenyl-4-yl}prop-2-enoic acid)

64-19-7

_99%

反应条件：

1.1 Reagents: Titanium tetrachloride Solvents: Dichloromethane ; 20 min, rt
1.2 Reagents: Triethylamine ; 10 min, rt; 3 - 4 h, rt

参考文献：

TiCl4-mediated olefination of aldehydes with acetic acid and alkyl acetates. A stereoselective approach to (E)-α,β-unsaturated carboxylic acids and esters

Augustine, John Kallikat; et al, Tetrahedron Letters, 2014, 55(24), 3503-3506

合成路线：1 步

141-82-2

_88%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 2 h, reflux

参考文献：

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Giancotti, Gilda; et al, European Journal of Medicinal Chemistry, 2018, 149, 56-68

合成路线：1 步

141-82-2

_85%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 24 h, 80 - 90 °C

参考文献：

Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents

Zhang, Hong-Jia; et al, Bioorganic & Medicinal Chemistry, 2011, 19(15), 4513-4519

合成路线：1 步

141-82-2

_85%

反应条件：

1.1 Reagents: Piperidine Solvents: Pyridine ; 24 h, 80 - 90 °C

参考文献：

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

Qian, Yong; et al, Bioorganic & Medicinal Chemistry, 2010, 18(14), 4991-4996

合成路线：1 步

113538-22-0

_87%

反应条件：

1.1 Reagents: Hydrogen peroxide , Sodium chlorite

参考文献：

Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α-β-unsaturated carbonyl compounds

Chang, Yi-Fan; et al, Tetrahedron Letters, 2008, 49(3), 543-547

合成路线：1 步

123133-22-2

124-38-9

_81%

反应条件：

1.1 Reagents: Lithium tert-butoxide , Bis(pinacolato)diborane Catalysts: Cuprous iodide , 1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Dimethylacetamide ; 24 h, 60 °C; 60 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Stereoselective defluorinative carboxylation of gem-difluoroalkenes with carbon dioxide

Xie, Shi-Liang; et al, Organic Chemistry Frontiers, 2019, 6(21), 3678-3682

合成路线：1 步

30166-77-9

124-38-9

_76%

反应条件：

1.1 Reagents: Tetrabutylammonium tetrafluoroborate Solvents: Dimethylformamide ; 8 h, 1 atm, 35 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Stereoselective electrochemical carboxylation of α,β-unsaturated sulfones

Yang, Zi-Xin; et al, Chinese Chemical Letters, 2023, 34(6),

合成路线：1 步

867-13-0

_75%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 0 °C; 30 min, 0 °C
1.2 1 - 3 h, rt
1.3 Reagents: Acetic acid , Water ; rt
1.4 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 6 - 24 h, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

Visible-light promoted oxidative cyclization of cinnamic acid derivatives using xanthone as the photocatalyst

Zhao, Bin; et al, Organic & Biomolecular Chemistry, 2021, 19(3), 568-573

合成路线：1 步

352530-23-5

124-38-9

_56%

反应条件：

1.1 Reagents: Potassium methoxide Catalysts: Cuprous chloride Solvents: Dimethylacetamide ; 24 h, 1 atm, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Carboxylation of Alkenyl Boronic Acids and Alkenyl Boronic Acid Pinacol Esters with CO2 Catalyzed by Cuprous Halide

Hong, Junting; et al, European Journal of Organic Chemistry, 2020, 2020(19), 2813-2818

合成路线：1 步

2350-89-2

558-13-4

_40%

反应条件：

1.1 Reagents: Dimethyl sulfoxide Catalysts: Cobalt iodide (CoI2) , Eosin ; 15 h, 50 °C

参考文献：

Carboxylation of styrenes with CBr4 and DMSO via cooperative photoredox and cobalt catalysis

Song, Cai-xia; et al, RSC Advances, 2017, 7(19), 11233-11243

合成路线：2 步

反应条件：

1.1 Solvents: Dimethylformamide , Tetrahydrofuran ; 60 °C
1.2 Reagents: Potassium carbonate , Sodium benzenesulfinate (resin-bound) Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: 1,2-Dimethoxyethane , Water ; 90 °C
1.3 Reagents: Dimethyl sulfoxide , Butyllithium ; 5 min, rt
1.4 Solvents: Tetrahydrofuran ; 30 min, rt
1.5 Solvents: Tetrahydrofuran ; rt
1.6 Reagents: Ozone Solvents: Dichloromethane ; 5 min, 0 °C
1.7 Reagents: Sodium methoxide Solvents: Methanol , Dichloromethane ; 3 h, rt
2.1 Reagents: Hydrogen peroxide , Sodium chlorite

参考文献：

Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α-β-unsaturated carbonyl compounds

Chang, Yi-Fan; et al, Tetrahedron Letters, 2008, 49(3), 543-547

合成路线：2 步

反应条件：

参考文献：

Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α-β-unsaturated carbonyl compounds

Chang, Yi-Fan; et al, Tetrahedron Letters, 2008, 49(3), 543-547

合成路线：2 步

1779-49-3

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Tetrahydrofuran ; 10 h, 75 °C
2.1 Reagents: Dimethyl sulfoxide Catalysts: Cobalt iodide (CoI2) , Eosin ; 15 h, 50 °C

参考文献：

Carboxylation of styrenes with CBr4 and DMSO via cooperative photoredox and cobalt catalysis

Song, Cai-xia; et al, RSC Advances, 2017, 7(19), 11233-11243

合成路线：2 步

2350-89-2

873-55-2

反应条件：

1.1 Reagents: Sodium acetate , Iodine Solvents: Acetonitrile ; 3 h, reflux; reflux → rt
1.2 Reagents: Sodium thiosulfate Solvents: Water
1.3 Reagents: Sodium bicarbonate Solvents: Water ; neutralized
2.1 Reagents: Tetrabutylammonium tetrafluoroborate Solvents: Dimethylformamide ; 8 h, 1 atm, 35 °C
2.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Stereoselective electrochemical carboxylation of α,β-unsaturated sulfones

Yang, Zi-Xin; et al, Chinese Chemical Letters, 2023, 34(6),

合成路线：1 步

76985-08-5

_47%

反应条件：

1.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
1.2 Solvents: Methanol ; 30 °C

参考文献：

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

合成路线：2 步

63024-50-0

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
2.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
2.2 Solvents: Methanol ; 30 °C

参考文献：

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

合成路线：3 步

63024-21-5

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
1.3 Solvents: Toluene ; 16 - 24 h, reflux
2.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
3.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
3.2 Solvents: Methanol ; 30 °C

参考文献：

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

合成路线：4 步

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt
1.2 Solvents: Dimethylformamide ; 0 °C; 3 h, rt; 4 h, 60 °C
2.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
2.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
2.3 Solvents: Toluene ; 16 - 24 h, reflux
3.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
4.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
4.2 Solvents: Methanol ; 30 °C

参考文献：

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

合成路线：5 步

3597-91-9

反应条件：

1.1 Reagents: N-Bromosuccinimide , Triphenylphosphine Solvents: Dichloromethane ; 30 min, rt
2.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt
2.2 Solvents: Dimethylformamide ; 0 °C; 3 h, rt; 4 h, 60 °C
3.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 4 - 6 h, reflux
3.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, -10 °C
3.3 Solvents: Toluene ; 16 - 24 h, reflux
4.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane , Water ; 7 h, reflux
5.1 Catalysts: β-Cyclodextrin , Phenylalanine ammonia-lyase Solvents: Water ; 40 h, pH 8.8, 30 °C
5.2 Solvents: Methanol ; 30 °C

参考文献：

Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky L- and D-Arylalanines

Filip, Alina; et al, ChemCatChem, 2018, 10(12), 2627-2633

合成路线：6 步