89076-64-2 (5-硝基-2-苯基吡啶,5-Nitro-2-phenylpyridine)

_99%

反应条件：

1.1 Catalysts: Di-μ-chlorobis(η3-2-propenyl)dipalladium , N1,N1,N2,N2-Tetrakis[(diphenylphosphino)methyl]-1,2-cyclohexanediamine Solvents: Dimethylformamide ; 0.5 h, 25 °C
1.2 Reagents: Potassium carbonate Solvents: Isopropanol ; 6 h, 60 °C

参考文献：

A new tetraphosphine and its application in Pd-catalyzed Suzuki cross-coupling reaction

Zhang, Yu; Yi, Tao; Wang, Kun; Fu, Haiyan; Chen, Hua; et al, Youji Huaxue, 2012, 32(4), 790-793

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Palladium diacetate Solvents: Ethylene glycol ; 20 min, 80 °C

参考文献：

A General and Highly Efficient Method for the Construction of Aryl-Substituted N-Heteroarenes

Liu, Chun; Han, Na; Song, Xiaoxiao; Qiu, Jieshan, European Journal of Organic Chemistry, 2010, (29), 5548-5551

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Palladium diacetate Solvents: Ethylene glycol ; 20 min, 80 °C

参考文献：

Method for preparing aryl aza-aromatic cycle compounds in alcohol solvent via Suzuki reaction

, China, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: 1,2-Dimethoxyethane , Water

参考文献：

The palladium-catalyzed Suzuki coupling of 2- and 4-chloropyridines

Lohse, Olivier; Thevenin, Philippe; Waldvogel, Erwin, Synlett, 1999, (1), 45-48

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Nickel palladium alloy Solvents: Dimethylformamide , Water ; 1 h, 110 °C

参考文献：

Ni/Pd core/shell nanoparticles supported on graphene as a highly active and reusable catalyst for Suzuki-Miyaura cross-coupling reaction

Metin, Oender; Ho, Sally Fae; Alp, Cemalettin; Can, Hasan; Mankin, Max N.; et al, Nano Research, 2013, 6(1), 10-18

合成路线：1 步

24388-23-6

_92%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide , Palladium Solvents: Dimethylformamide , Water ; 3 h, 80 °C

参考文献：

Cross-Coupling in the Preparation of Pharmaceutically Relevant Substrates using Palladium Supported on Functionalized Mesoporous Silicas

El Kadib, Abdelkrim; McEleney, Kevin; Seki, Tomohiro; Wood, Thomas K.; Crudden, Cathleen M., ChemCatChem, 2011, 3(8), 1281-1285

合成路线：1 步

14150-94-8

98-86-2

_90%

反应条件：

1.1 Reagents: Ammonium acetate Solvents: Ethanol ; 5 h, heated

参考文献：

Substituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation

Asahara, Haruyasu, Procedia Engineering, 2017, 174, 1046-1057

合成路线：1 步

14150-94-8

98-86-2

_90%

反应条件：

1.1 Reagents: Ammonium acetate Solvents: Ethanol ; 5 h, heated

参考文献：

Synthesis of 2-Aryl-5-Nitropyridines by Three-Component Ring Transformation of 3,5-Dinitro-2-Pyridone

Le, Song Thi; Asahara, Haruyasu; Kobiro, Kazuya; Sugimoto, Ryuichi; Saigo, Kazuhiko; et al, Asian Journal of Organic Chemistry, 2014, 3(3), 297-302

合成路线：1 步

603-33-8

_90%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: Triphenylphosphine , Palladium diacetate Solvents: N-Methyl-2-pyrrolidone ; 2 h, 110 °C; 110 °C → rt
1.2 Solvents: Water ; rt

参考文献：

Triarylbismuthanes as Threefold Aryl-Transfer Reagents in Regioselective Cross-Coupling Reactions with Bromopyridines and Quinolines

Rao, Maddali L. N.; Dhanorkar, Ritesh J., European Journal of Organic Chemistry, 2014, 2014(24), 5214-5228

合成路线：1 步

14150-94-8

7196-01-2

_90%

反应条件：

1.1 Reagents: Ammonia Solvents: Ethanol

参考文献：

Nucleophilic reaction upon electron-deficient pyridone derivatives. X. One-pot synthesis of 3-nitropyridines by ring transformation of 1-methyl-3,5-dinitro-2-pyridone with ketones or aldehydes in the presence of ammonia

Tohda, Yasuo; Eiraku, Miyuki; Nakagawa, Takao; Usami, Yumi; Ariga, Masahiro; et al, Bulletin of the Chemical Society of Japan, 1990, 63(10), 2820-7

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Triphenylphosphine , Palladium Solvents: 1,2-Dichloroethane , Water ; 9 h, 80 °C

参考文献：

Palladium Charcoal-Catalyzed Suzuki-Miyaura Coupling to Obtain Arylpyridines and Arylquinolines

Tagata, Tsuyoshi; Nishida, Mayumi, Journal of Organic Chemistry, 2003, 68(24), 9412-9415

合成路线：1 步

_79%

反应条件：

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium , 1,2,3-Oxadiazolium, 4-carboxy-5-hydroxy-3-phenyl-, inner salt, lithium salt (1:1… Solvents: 1,4-Dioxane ; 5 min; 25 min, rt
1.2 Reagents: Acetic acid , Sodium carbonate Solvents: Water ; 6 h, 80 °C

参考文献：

Suzuki-Miyaura Cross-Couplings under Acidic Conditions

Pruschinski, Lucas; Luecke, Ana-Luiza; Freese, Tyll; Kahnert, Sean-Ray; Mummel, Sebastian; et al, Synthesis, 2020, 52(6), 882-892

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: Triphenylphosphine , 2103932-14-3 Solvents: Water ; 18 h, 100 °C

参考文献：

A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents

Ramakrishna, Visannagari; Rani, Morla Jhansi; Reddy, Nareddula Dastagiri, European Journal of Organic Chemistry, 2017, 2017(48), 7238-7255

合成路线：1 步

201673-70-3

_77%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Triphenylphosphine , Palladium diacetate Solvents: 1,4-Dioxane ; 7 h, 110 °C
1.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

Palladium(II) catalyzed Suzuki/Sonogashira cross-coupling reactions of sulfonates: an efficient approach to C2-functionalized pyrimidines and pyridines

Quan, Zheng-Jun; Jing, Fu-Qiang; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun, European Journal of Organic Chemistry, 2013, 2013(31), 7175-7183

合成路线：1 步

201673-70-3

_76%