89292-78-4 (1-（2-氟苄基）哌嗪,1-(2-Fluorobenzyl)piperazine)

_89%

反应条件：

1.1 Solvents: Acetonitrile ; 0 °C; 24 h, rt

参考文献：

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Panek, Dawid; Wieckowska, Anna; Wichur, Tomasz; Bajda, Marek; Godyn, Justyna; et al, European Journal of Medicinal Chemistry, 2017, 125, 676-695

合成路线：1 步

_80%

反应条件：

1.1 Solvents: Toluene ; 2 h, 85 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt
1.3 Reagents: Sodium hydroxide ; pH 14, rt

参考文献：

Synthesis and preliminary pharmacological evaluation of 4'-arylmethyl analogues of clozapine. I. The effect of aromatic substituents

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A., Australian Journal of Chemistry, 2002, 55(9), 565-576

合成路线：1 步

_75%

反应条件：

1.1 Solvents: Isopropanol , Water ; 5 - 6 h, 0 - 5 °C; overnight, rt

参考文献：

Synthesis of 2-(4-substituted benzylpiperazin-1-yl)ethyl benzoates

Han, Sheng-hua; Men, Shuang-ming; Wen, Xue-shan; Chen, Jian-xin, Shanxi Nongye Daxue Xuebao, 2010, 30(1), 77-80

合成路线：1 步

_65%

反应条件：

1.1 Solvents: Acetonitrile ; 0.5 - 1 h, rt

参考文献：

Synthesis and bioactive evaluations of novel benzotriazole compounds as potential antimicrobial agents and the interaction with calf thymus DNA

Ren, Yu; Zhang, Hui Zhen; Zhang, Shao Lin; Luo, Yun Lei; Zhang, Ling; et al, Journal of Chemical Sciences (Berlin, 2015, 127(12), 2251-2260

合成路线：1 步

_41%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt; 4 h, reflux

参考文献：

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors

Zhang, Cunlong; Tan, Chunyan; Zu, Xuyu; Zhai, Xin; Liu, Feng; et al, European Journal of Medicinal Chemistry, 2011, 46(4), 1404-1414

合成路线：1 步

57260-71-6

446-48-0

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dichloromethane ; 10 h, reflux
1.2 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 2 h, rt

参考文献：

The design and synthesis of benzylpiperazine-based edaravone derivatives and their neuroprotective activities

Gao, Mengjie; Ma, Shuangyan; Xu, Tong; Jiang, Nan; Xu, Yi; et al, Journal of Chemical Research, 2022, 46(6),

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 6 h, reflux

参考文献：

Synthesis and bioactivities of phenazine-1-carboxylic piperazine derivatives

Han, Fei; Yan, Ru; Zhang, Min; Xiang, Zhu; Wu, Qinglai; et al, Natural Product Research, 2020, 34(9), 1282-1287

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; 6 h, reflux

参考文献：

Synthesis and Antimicrobial Evaluation of Aminoguanidine and 3-amino- 1,2,4-triazole Derivatives as Potential Antibacterial Agents

Zhang, Tian-Yi; Li, Chao; Li, Ya-Ru; Li, Xiao-Zhen; Sun, Liang-Peng; et al, Letters in Drug Design & Discovery, 2016, 13(10), 1063-1075

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; pH 12, 78 °C

参考文献：

Synthesis and effects of 2-(4-(4-benzyl-substituted)piperazin-1-yl)ethyl 2-(1-(pyridin-2-yl)ethoxy) acetates on learning and memory facilitation in mice

Song, Ming-xia; Hong, Lan; Li, Ming-zhu, Yanbian Daxue Yixue Xuebao, 2012, 35(3), 173-176

合成路线：1 步

63074-07-7

反应条件：

1.1 Solvents: Ethanol ; rt; 3 h, rt → reflux; cooled
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 10
1.3 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 10 h, reflux; cooled
1.4 Reagents: Water

参考文献：

Synthesis and antifungal activities of 1-(1H-1,2,4-triazole-1-yl)-2-(t-butyl)-3-[(4-substituted benzyl)-piperazin-1-yl]-2-propanols

Men, Xiufeng; Liu, Chaomei; Cao, Yongbing; He, Qiuqin; Zhao, Lihua, Zhongguo Yaowu Huaxue Zazhi, 2006, 16(4), 208-213

合成路线：1 步