89482-00-8 (扎托洛芬,zaltoprofen)

扎托洛芬;扎托布洛芬;扎托洛芬,扎托布洛芬;

zaltoprofen;Zaltoprofen intermediate;Soleton;Peon (TN);Zaltoprofen (+-)-;MFCD00864323;AMY421;FT-0656731;2-(10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid;NCGC00263585-01;HMS3744O11;Zaltoprofen [INN];74711-43-6;Tox21_113634;Zaltoprofeno;GS-3949;AKOS015895991;Dibenzo(b,f)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-;CHEBI:32306;CN 100;DTXSID0049076;FT-0630837;2-{10-oxo-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-6-yl}propanoic acid;CN100;10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid;2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid;CCG-267450;(+-)-2-(10,11-Dihydro-10-oxodibenzo(b,f)thiepin-2-yl)propionic acid;Zaltoprofen (JP17/INN);Zaltoprofeno [INN-Spanish];F0001-2421;MLS004774050;Zaltoprofene [INN-French];NCGC00263585-04;s3008;A838204;Z0021;2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid;NS00037652;AB01565848_02;Zaltoprofene;2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)-propionic acid;EINECS 277-973-5;SW219801-1;SCHEMBL124047;MLS006010214;DTXCID0029002;10,11-dihydro-alpha-methyl-10-oxodibenzo[b,f]thiepin-2-acetic acid;GLXC-26617;ZC-102;2-(6-Oxo-5a,6-dihydrodibenzo[b,f]thiepin-3-yl)propanoic acid;(+-)-10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid;NCGC00183878-01;10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-aceticacid;2-(10-Oxo-10,11-dihydrodibenzo-[b,f]thiepin-2-yl)propanoic acid;Zaltoprofen [INN:JAN];MUXFZBHBYYYLTH-UHFFFAOYSA-N;C17H14O3S;CN-100;Zaltoprofenum;ZALTOPROFEN [MI];HMS3885E03;ZALTOPROFEN [WHO-DD];AC-32652;H8635NG3PY;Tox21_113634_1;Soreton;DB06737;CAS-74711-43-6;SMR003500719;D01547;HY-B0619;HMS3656J14;ZALTOPROFEN [JAN];10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid;2-(10,11-dihydro-10-oxodibenzo [b,f] thiepin-2-yl)propionic acid;BCP02387;1166864-09-0;ZALTOPROFEN [MART.];2-(10-Oxo-10,11-dihydro-dibenzo[b,f]thiepin-2-yl)-propionic acid;Peon;Zaltoprofen sodium salt;UNII-H8635NG3PY;CHEMBL1765291;Zaltoprofenum [INN-Latin];89482-00-8;10,11-dihydro-a-methyl-10-oxodibenzo[b,f]thiepin-2-acetic acid;SBI-0654128.0001;BRD-A00578795-001-04-3;Zaltoprofen (JP18/INN);

MUXFZBHBYYYLTH-UHFFFAOYSA-N

1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

S1C2C=CC=CC=2C(CC2C=C(C=CC1=2)C(C(=O)O)C)=O

扎托洛芬原料药有抗炎镇痛作用。适用于慢性风湿性关节炎、变形性关节症、腰痛症、肩周炎、颈肩腕综合征以及手术后、外伤后、拔牙后的消炎镇痛。

化合物(I)和多聚磷酸在120℃搅拌,再加入水,反应得到扎托洛芬。