89-93-0 (邻甲基苄胺,1-(2-methylphenyl)methanamine)

_99%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Nickel , Rhenium , Silica Solvents: Methanol , Water ; 90 min, 1 MPa, 120 °C

参考文献：

Highly efficient and stable rhenium modified nickel catalyst for hydrogenation of nitriles to primary amines

Ma, Zhuo; Ma, Lei; Chen, Xingkun; Wang, Xuepeng; Tan, Yuan; et al, Chemical Engineering Journal (Amsterdam, 2023, 466,

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Titanium tetrachloride Solvents: Diethyl ether ; 0 °C
1.2 Reagents: Ammonia borane ; 1 min, 0 °C; 0 °C → 25 °C; 3 h, 25 °C; 25 °C → 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; 30 min, 0 °C
1.4 Reagents: Sodium hydroxide Solvents: Water ; pH 11

参考文献：

Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane

Ramachandran, P. Veeraraghavan; Alawaed, Abdulkhaliq A., Molecules, 2023, 28(1),

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen , Hydrazine hydrate (1:1) Catalysts: Ruthenium Solvents: Methanol ; rt; 16 h, 2 MPa, 80 °C

参考文献：

Efficient and selective approach to biomass-based amine by reductive amination of furfural using Ru catalyst

Zou, Hongtao; Chen, Jinzhu, Applied Catalysis, 2022, 309,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Ruthenium (boron nitride support) , Boron nitride Solvents: Methanol , Water ; 6.5 h, 1.0 MPa, 90 °C

参考文献：

Self-regulated catalysis for the selective synthesis of primary amines from carbonyl compounds

Gao, Mingxia; Jia, Xiuquan; Ma, Jiping; Fan, Xiaomeng; Gao, Jin; et al, Green Chemistry, 2021, 23(18), 7115-7121

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Cobalt (supported on metal oxide) Solvents: Isopropanol , Water ; 24 h, 20 bar, 100 °C

参考文献：

A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation

Formenti, Dario; Mocci, Rita; Atia, Hanan; Dastgir, Sarim; Anwar, Muhammad; et al, Chemistry - A European Journal, 2020, 26(67), 15589-15595

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: 4-Nitro-1,2-phenylenediamine (complexes with Pd) Solvents: Water ; 3 h, pH 1, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; basified, rt

参考文献：

Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O

Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; et al, Green Chemistry, 2019, 21(4), 830-838

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrogen , Ammonium hydroxide Catalysts: Nickel , Aluminum zinc oxide Solvents: Hexane ; 24 h, 10 bar, 60 °C

参考文献：

Room-temperature synthesis of primary amines by selective hydrogenation of nitriles over ZnAlOx supported Ni catalysts

Zhao, Huanyu; He, Yurong; Wang, Xiaochen; He, Jie ; Liu, Anqiu; et al, Applied Catalysis, 2023, 655,

合成路线：1 步

527-85-5

_98%

反应条件：

1.1 Reagents: Pinacolborane Catalysts: Tetracosa-μ3-hydroxyoctakis(methanol)di-μ6-oxoeicosakis(1,1,1-trifluoro-2,4-pent… Solvents: Toluene ; rt → 110 °C; 24 h, 110 °C

参考文献：

Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides

Weng, Zhen-Zhang; Chen, Chao-Long; Ye, Long-Wu; Long, La-Sheng; Zheng, Lan-Sun; et al, Science China: Chemistry, 2023, 66(2), 443-448

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Nickel boride (Ni2B) (supported on TS-1 mol. sieve) Solvents: Isopropanol ; 0.5 MPa, rt → 120 °C; 2.5 h, 4 MPa, 120 °C

参考文献：

General Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters

Ke, Da; Zhou, Shaodong, International Journal of Molecular Sciences, 2022, 23(16),

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Ammonia Solvents: Methanol ; 1 h, 30 °C
1.2 Reagents: Hydrogen Catalysts: Nickel , Silica ; 3.5 min, 1 MPa, 70 °C

参考文献：

Continuous reductive amination to synthesize primary amines with high selectivity in flow

Zhang, Jiahao; Yin, Jiabin; Duan, Xiaonan; Zhang, Chenghao; Zhang, Jisong, Journal of Catalysis, 2023, 420, 89-98

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Ammonium acetate , Hydrogen , Ammonia Catalysts: (OC-6-33)-Bis(glycinato-κN,κO)[1,1′-(1,3-propanediyl)bis[1,1-diphenylphosphine-κ… Solvents: Isopropanol ; 18 h, 50 bar, 130 °C

参考文献：

Easily Synthesized Ru Catalyst Efficiently Converts Carbonyl Compounds and Ammonia into Primary Amines

Pan, Jia-Sheng; Zhang, Rui; Ma, Shuang-Shuang; Han, Li-Jun; Xu, Bao-Hua, ChemistrySelect, 2020, 5(35), 10933-10938

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Nickel Solvents: tert-Butanol ; 24 h, 25 - 27 bar, 120 °C

参考文献：

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

Murugesan, Kathiravan ; Beller, Matthias; Jagadeesh, Rajenahally V., Angewandte Chemie, 2019, 58(15), 5064-5068

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Vitride Solvents: Toluene

参考文献：

Reductions by metal alkoxyaluminum hydrides. Part II. Carboxylic acids and derivatives, nitrogen compounds, and sulfur compounds

Malek, Jaroslav, Organic Reactions (Hoboken, 1988, 36,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Alumina , Nickel Solvents: tert-Butanol ; 12 h, 5 bar, 100 °C

参考文献：

A general and selective Ni-catalysed reductive amination using hydrazine hydrate as facile hydrogen and nitrogen sources

Zhu, Jiazheng; Duan, Chengjie; Ye, Sen; Zhang, Qizhong; Li, Kun; et al, New Journal of Chemistry, 2023, 47(23), 11318-11324

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Cobalt (nitrogen-doped activated carbon-supported) Solvents: Methanol , Water ; 6 h, 1 MPa, 110 °C

参考文献：

Reductive Amination of Carbonyl Compounds with Ammonia and Hydrogenation of Nitriles to Primary Amines with Heterogeneous Cobalt Catalysts

Liu, Junmei; Guo, Wanwan; Sun, Hao; Li, Ruyue; Feng, Zhipeng; et al, Chemical Research in Chinese Universities, 2019, 35(3), 457-462

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Hydrogen , Ammonia Catalysts: Cobalt (graphene-encapsulated) Solvents: Methanol ; 4 h, 2 MPa, 100 °C

参考文献：

Facile manner in regulating the graphene-shelled structure of cobalt nanoparticles for the synthesis of amines

Zhuang, Xiuzheng; Liu, Jianguo; Ma, Longlong, ChemRxiv, 2021, 1, 1-15

合成路线：1 步

_91%