91026-00-5 (N-苄基-2,3-二溴马来酰亚胺,1-Benzyl-3,4-dibromopyrrole-2,5-dione)

_92%

反应条件：

1.1 Solvents: Acetic acid , Water ; 3 h, reflux

参考文献：

Synthesis of substituted bis(heteroaryl)maleimides

Dubernet, Mathieu; Caubert, Virginie; Guillard, Jerome; Viaud-Massuard, Marie-Claude, Tetrahedron, 2005, 61(19), 4585-4593

合成路线：1 步

1442447-48-4

_86%

反应条件：

1.1 Solvents: Dichloromethane ; 20 min, rt

参考文献：

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

Castaneda, Lourdes; Wright, Zoe V. F.; Marculescu, Cristina; Tran, Trang M.; Chudasama, Vijay; et al, Tetrahedron Letters, 2013, 54(27), 3493-3495

合成路线：1 步

1122-12-9

_86%

反应条件：

1.1 Solvents: Acetic acid ; 10 min, rt; 2 h, reflux; reflux → rt

参考文献：

Total synthesis of (±)-camphorataimides and (±)-himanimides by NaBH4/Ni(OAc)2 or Zn/AcOH stereoselective reduction

Cheng, Chia-Fu; Lai, Zhen-Chang; Lee, Yean-Jang, Tetrahedron, 2008, 64(19), 4347-4353

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 12 h, 23 °C

参考文献：

Synthesis and biological evaluation of new 3,4-diarylmaleimides as enhancers (modulators) of doxorubicin cytotoxic activity on cultured tumor cells from a real case of breast cancer

Gutierrez-Cano, Jessica R.; Nahide, Pradip D.; Ramadoss, Velayudham; Satkar, Yuvraj; Ortiz-Alvarado, Rafael; et al, Journal of the Mexican Chemical Society, 2017, 61(1), 41-49

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 18 h, rt

参考文献：

Synthesis and biological evaluation of maleimide derivatives for neuronal differentiation

Ramu, Ravirala; Kim, Se Hoan; Kang, Seung Kyu; Kang, Nam Sook; Ahn, Jin Hee; et al, Journal of the Korean Chemical Society, 2009, 53(4), 471-475

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone

参考文献：

Synthesis of the aromatic and monosaccharide moieties of staurosporine

Joyce, Richard P.; Gainor, James A.; Weinreb, Steven M., Journal of Organic Chemistry, 1987, 52(7), 1177-85

合成路线：1 步

_74%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Acetone ; 18 h, rt

参考文献：

Mechanochemical Fluorescence Switching in Polymers Containing Dithiomaleimide Moieties

Karman, Marc; Verde-Sesto, Ester; Weder, Christoph ; Simon, Yoan C., ACS Macro Letters, 2018, 7(9), 1099-1104

合成路线：1 步

1122-12-9

_70%

反应条件：

1.1 Solvents: Acetic acid ; 22 h, 120 °C

参考文献：

Maleimide-based acyclic enediyne for efficient DNA-cleavage and tumor cell suppression

Song, Depeng; Sun, Shiyuan; Tian, Yu; Huang, Shuai; Ding, Yun; et al, Journal of Materials Chemistry B: Materials for Biology and Medicine, 2015, 3(16), 3195-3200

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; overnight, rt

参考文献：

A Simple Mechanochromic Mechanophore Based on Aminothiomaleimide

Tan, Min; Hu, Zhitao; Dai, Yunkai; Peng, Yanling; Zhou, Yecheng ; et al, ACS Macro Letters, 2021, 10(11), 1423-1428

合成路线：1 步