91424-40-7 (3-叔丁基二甲硅氧基戊二酸酐,3-(tert-Butyldimethylsilyl)oxyglutaric Anhydride)

CAS号:
91424-40-7
中文名称:
3-叔丁基二甲硅氧基戊二酸酐
英文名称:
3-(tert-Butyldimethylsilyl)oxyglutaric Anhydride
安全信息:
分子式:
C11H20O4Si
分子量:
244.35960483551

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)名称与标识符

名称

中文别名:
3-叔丁基二甲硅氧基戊二酸酐;(3R)-3叔丁基二甲硅氧基戊二酸苯羟乙酸酯;15R-比马前列素;2-乙氧基苯并咪唑-7-羧酸甲酯;3-(叔丁基二甲基硅氧基)戊二酸酐;3,3-二甲基-1-丁炔;3-叔丁基二甲硅氧基戊二酸酐 J-1;瑞舒伐他汀钙J-3;瑞舒伐他汀钙侧链A6;瑞舒伐他汀钙侧链C6;3-TBDMSO戊二酸酐;
英文别名:
3-(tert-Butyldimethylsilyloxy)glutaric anhydride;3-(t-BUTYLDIMETHYLSILOXY)GLUTARIC ANHYDRIDE;3-[(Tert-Butyldimethylsilyl)oxy] Pentanedioic Anhydride;3-[(tert-Butyldimethylsilyl)oxy]glutaric anhydride;4-[tert-butyl(dimethyl)silyl]oxyoxane-2,6-dione;Rosuvastatin J-3;: 3-(tert-Butyldimethylsilyloxy)glutaric anhydride;2H-Pyran-2,6(3H)-dione,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]dihydro-;3-[(tert-Butyldimethylsilyl)oxy]glutaricanhydride;4-((tert-Butyldimethylsilyl)oxy)dihydro-2H-pyran-2,6(3H)-dione;3-(tert-butyldimethylsilyloxy)glutaric anhydride,;4-(tert-butyldimethylsilyloxy)dihydro-2H-pyran-2,6(3H)-dione;4-[(tert-butyldimethylsilyl)oxy]oxane-2,6-dione;C11H20O4Si;RXAJGRHLLRGVSB-UHFFFAOYSA-N;BCP10931;AK;4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]dihydro-2H-pyran-2,6(3H)-dione (ACI);91424-40-7;3-(tert-Butyldimethylsilyloxy)glutaricanhydride;DTXSID40399829;O11057;3-(tert-butyldimethylsiloxy)glutaric anhydride;SY017618;3-[(tert-butyldimethylsilyl)oxy]pentanedioic anhydride;AKOS015900599;CS-W012734;3-[(tert-Butyldimethyl silyl)oxy]glutaric anhydride;MFCD00075235;GS-3347;3-(tert-Butyldimethylsilyloxy)glutaric anhydride, 99%;AC-769;SCHEMBL1295672;

标识符

MDL:
MFCD00075235
InChIKey:
RXAJGRHLLRGVSB-UHFFFAOYSA-N
Inchi:
1S/C11H20O4Si/c1-11(2,3)16(4,5)15-8-6-9(12)14-10(13)7-8/h8H,6-7H2,1-5H3
SMILES:
O=C1CC(O[Si](C(C)(C)C)(C)C)CC(=O)O1

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)物化性质

实验特性

  • LogP : 2.24040
  • PSA : 52.60000
  • 折射率 : 1.4510
  • 沸点 : 302.4°C at 760 mmHg
  • 熔点 : 79-81 °C (lit.)
  • 闪点 : >113°(235°F)
  • 颜色与性状 : 未确定
  • 敏感性 : Moisture Sensitive
  • 密度 : 1.03

计算特性

  • 精确分子量 : 244.11300
  • 氢键供体数量 : 0
  • 氢键受体数量 : 4
  • 可旋转化学键数量 : 3
  • 同位素质量 : 244.113
  • 重原子数量 : 16
  • 复杂度 : 288
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 0
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 1
  • 疏水参数计算参考值(XlogP) : 无
  • 互变异构体数量 : 3
  • 表面电荷 : 0
  • 拓扑分子极性表面积 : 52.6

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)安全信息

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)海关数据

海关编码:
2931900090
海关数据:

中国海关编码:

2931900090

概述:

2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

Summary:

2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)生产方法和用途

用途:
瑞舒伐他汀钙中间体。

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)推荐厂家 更多厂家(54)

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3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)合成路线

合成路线:1 步
反应条件:
参考文献:
Synthesis of 3-(tert-butyldimethylsilyloxy) glutaric anhydride
Jiang, Cheng-jun; et al, Zhejiang Keji Xueyuan Xuebao, 2008, 20(2), 107-109
合成路线:1 步
反应条件:
参考文献:
Synthesis of 3-[(tert-butyldimethylsilyl)oxy]glutaric anhydride from citric acid
Jiang, C. J.; et al, Asian Journal of Chemistry, 2014, 26(22), 7867-7868
合成路线:1 步
反应条件:
参考文献:
Toward the total synthesis of lophotoxin - New methodologies and synthetic strategies
Wipf, Peter; et al, Canadian Journal of Chemistry, 2006, 84(10), 1226-1241
合成路线:1 步
反应条件:
参考文献:
Synthesis of 3-[(tert-butyldimethylsilyl)oxy]glutaric anhydride from citric acid
Jiang, C. J.; et al, Asian Journal of Chemistry, 2014, 26(22), 7867-7868
合成路线:1 步
参考文献:
Synthesis of GABOB and GABOB-based chiral units possessing distinct protecting groups
Ivsic, Trpimir; et al, European Journal of Organic Chemistry, 2014, 2014(3), 631-638
合成路线:1 步
参考文献:
Axial preference of bulky group- and electron-withdrawing group-substituted oxygen atom on the chair-type-cyclohexanone, -glutaric anhydride, and -glutarimide
Nagao, Yoshimitsu; et al, Chemistry Letters, 1990, (9), 1503-6
合成路线:2 步
反应条件:
参考文献:
Synthesis of 3-[(tert-butyldimethylsilyl)oxy]glutaric anhydride from citric acid
Jiang, C. J.; et al, Asian Journal of Chemistry, 2014, 26(22), 7867-7868
合成路线:2 步
反应条件:
参考文献:
Synthesis of 3-(tert-butyldimethylsilyloxy) glutaric anhydride
Jiang, Cheng-jun; et al, Zhejiang Keji Xueyuan Xuebao, 2008, 20(2), 107-109
合成路线:2 步
参考文献:
A Practical Synthesis of Rosuvastatin and Other Statin Intermediates
Tartaggia, Stefano; et al, European Journal of Organic Chemistry, 2015, 2015(19), 4102-4107
合成路线:2 步
反应条件:
参考文献:
Synthesis of 3-[(tert-butyldimethylsilyl)oxy]glutaric anhydride from citric acid
Jiang, C. J.; et al, Asian Journal of Chemistry, 2014, 26(22), 7867-7868
合成路线:3 步
反应条件:
参考文献:
Synthesis of 3-(tert-butyldimethylsilyloxy) glutaric anhydride
Jiang, Cheng-jun; et al, Zhejiang Keji Xueyuan Xuebao, 2008, 20(2), 107-109
合成路线:3 步
反应条件:
参考文献:
A Practical Synthesis of Rosuvastatin and Other Statin Intermediates
Tartaggia, Stefano; et al, European Journal of Organic Chemistry, 2015, 2015(19), 4102-4107

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7)相关文献

3-叔丁基二甲硅氧基戊二酸酐(91424-40-7) MSDS

基础信息

  Material Safety Data Sheet

Section 1. Identi?cation of the substance
    Product Name:      3-(tert-Butyldimethylsilyloxy)glutaric anhydride    
    Synonyms:

Section 2. Hazards identi?cation
    Harmful by inhalation, in contact with skin, and if swallowed.
    H315:        Causes skin irritation    
    H319:        Causes serious eye irritation    
    H335:        May cause respiratory irritation    
    P261:        Avoid breathing dust/fume/gas/mist/vapours/spray    
    P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
    and easy to do – continue rinsing

Section 3. Composition/information on ingredients.
    Ingredient name:        3-(tert-Butyldimethylsilyloxy)glutaric anhydride    
    CAS number:        91424-40-7    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
    Eye contact:
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed    
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Storage:        Store in closed vessels, refrigerated.    

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed    
    No data
    Boiling point:
    Melting point:        No data    
    Flash point:        No data    
    Density:        No data    
    Molecular formula: C11H20O4Si
    Molecular weight: 244.4

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, sulfur oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A