91-66-7 (N,N-二乙基苯胺,N,N-Diethylaniline)

_96%

反应条件：

1.1 Catalysts: Alumina (10 wt% Cu and 5 wt% Co) Solvents: Ethanol ; 4 h, 1 bar, 170 °C

参考文献：

Tunable mono- and di-methylation of amines with methanol over bimetallic CuCo nanoparticle catalysts

Li, Ke-Ming; et al, Green Chemistry, 2022, 24(15), 5965-5977

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Cobalt dinitrate (poly. with hexamethylenetetramine) ; 14 h, 2 MPa, 210 °C

参考文献：

A strategy of two-step tandem catalysis towards direct N-alkylation of nitroarenes with ethanol via facile fabricated novel Co-based catalysts derived from coordination polymers

Wang, Jing; et al, Journal of Catalysis, 2019, 376, 106-118

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: 2,5-Dihydroxyterephthalic acid (complexes with metals) , Magnesium , Nickel , Cobalt (complexes with 2,5-Dihydroxyterephthalic acid) ; 12 h, 170 °C

参考文献：

Boosting performance for hydrogenation-alkylation tandem reaction catalyzed by banana-like MgO-based solid solution confined Ni-Co alloy catalyst: Fabricated by a MTV-MOFs templated strategy

Li, Weizuo; et al, Molecular Catalysis, 2022, 529,

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Nickel Solvents: Ethanol ; 4 h, 1 MPa, 240 °C
1.2 Reagents: Water ; cooled

参考文献：

Highly Active Ni Nanoparticles on N-doped Mesoporous Carbon with Tunable Selectivity for the One-Pot Transfer Hydroalkylation of Nitroarenes with EtOH in the Absence of H2

Tao, Yuewen; et al, ChemCatChem, 2021, 13(19), 4243-4250

合成路线：1 步

64-19-7

_99%

反应条件：

1.1 Catalysts: 1,2-Bis(diphenylphosphino)ethane , [η2:η2-1,3-diethenyl-1,1,3,3-tetramethyldisiloxane]platinum Solvents: Butyl ether ; 10 min, rt
1.2 Reagents: Phenylsilane Solvents: Hexadecane ; 18 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ; 3 h, rt

参考文献：

Direct Catalytic N-Alkylation of Amines with Carboxylic Acids

Sorribes, Ivan; et al, Journal of the American Chemical Society, 2014, 136(40), 14314-14319

合成路线：1 步

64-19-7

_87%

反应条件：

1.1 Reagents: Methanesulfonic acid , Ammonia borane Solvents: Acetonitrile ; 5 h, 60 °C

参考文献：

Reductive N-alkylation of primary and secondary amines using carboxylic acids and borazane under mild conditions

Wei, Yahui; et al, Organic Chemistry Frontiers, 2018, 5(24), 3510-3514

合成路线：1 步

64-19-7

_82%

反应条件：

1.1 Reagents: Phenylsilane Catalysts: 2903426-60-6 Solvents: p-Xylene ; 12 h, 80 °C
1.2 Reagents: Sodium hydroxide Solvents: Ethyl acetate , Water ; 30 min

参考文献：

Iridium-catalyzed reductive amination of carboxylic acids

Ouyang, Lu; et al, Journal of Catalysis, 2023, 418, 283-289

合成路线：1 步

78-40-0

_99%

参考文献：

Alkylation of amines. I

Billman, John H.; et al, Journal of the American Chemical Society, 1942, 64, 2977-8

合成路线：1 步

78-40-0

参考文献：

Arylamines

Scholz, U.; et al, Science of Synthesis, 2007, 31, 1565-1678

合成路线：1 步

108-86-1

_97%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethyl sulfoxide ; rt → reflux; 5 min, reflux

参考文献：

Rapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst

Shi, Lei; et al, Organic Letters, 2003, 5(19), 3515-3517

合成路线：1 步

108-86-1

_96%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Copper oxide (CuO) (silica supported) , Silica Solvents: Dimethyl sulfoxide ; 40 min, 120 °C

参考文献：

C-N cross-coupling reaction catalysed by efficient and reusable CuO/SiO2 nanoparticles under ligand-free conditions

Hajipour, Abdol R.; et al, Applied Organometallic Chemistry, 2014, 28(11), 809-813

合成路线：1 步

108-86-1

_95%

反应条件：

1.1 Reagents: Sodium tert-butoxide Catalysts: Copper oxide (Cu2O) Solvents: N-Methyl-2-pyrrolidone ; 24 h, 100 °C; 100 °C → 25 °C
1.2 Reagents: Water ; 25 °C

参考文献：

Copper catalyzed coupling of aryl chlorides, bromides and iodides with amines and amides

Xu, Hanhui; et al, Chemical Communications (Cambridge, 2009, (13), 1715-1717

合成路线：1 步

74-96-4

_97%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Hexadecyl-3-methylimidazolium bromide Solvents: Water ; 6 h, 1 atm, 60 °C

参考文献：

Study on synthesis of N,N-diethylaniline using ionic liquids as phase transfer catalysts

Shao, Li-li; et al, Fenzi Cuihua, 2008, 22(2), 101-104

合成路线：1 步

74-96-4

_96%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tetraethylammonium iodide Solvents: Water ; 5 h, 55 °C; 55 °C → rt
1.2 Reagents: Acetic anhydride ; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2
1.4 Reagents: Sodium hydroxide Solvents: Water ; pH 11 - 12

参考文献：

Study of phase transfer catalytic synthesis of N,N-diethylaniline with tetraethyl ammonium iodide

Tian, Qing-wei, Dalian Jiaotong Daxue Xuebao, 2009, 30(1), 41-44

合成路线：1 步

74-96-4

_96%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tetraethylammonium chloride Solvents: Water ; 5 h, 75 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 11 - 12

参考文献：

Study on phase transfer catalytic synthesis of N,N-diethylaniline with tetraethylammonium chloride as catalyst

Tian, Qing-wei, Huaxue Gongye Yu Gongcheng (Tianjin, 2004, 21(1), 73-74

合成路线：1 步

103-69-5

_96%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Chloro[2-(diphenylphosphino-κP)benzenesulfonato-κO][(1,2,3,4,5,6-η)-1-methyl-4-(… Solvents: Toluene ; 24 h, 150 °C

参考文献：

Ruthenium-catalyzed chemoselective alkylation of nitroarenes with alkanols

Ma, Shuang-Shuang; et al, Organic Chemistry Frontiers, 2021, 8(23), 6710-6719

合成路线：1 步

826-42-6

_95%

反应条件：

1.1 Reagents: Bis(pinacolato)diborane Solvents: Acetonitrile ; 10 min, rt
1.2 Reagents: Ethylenediamine ; 1 h, rt

参考文献：

Reduction of Amine N-Oxides by Diboron Reagents

Kokatla, Hari Prasad; et al, Journal of Organic Chemistry, 2011, 76(19), 7842-7848

合成路线：1 步

826-42-6

_85%

反应条件：

1.1 Reagents: Titanium tetrachloride , Sodium iodide Solvents: Acetonitrile

参考文献：

Titanium tetrachloride/sodium iodide - a novel, efficient reagent for mild reduction of the nitrogen-oxygen bond in amine N-oxides and nitrones

Balicki, Roman, Chemische Berichte, 1990, 123(3), 647-8

合成路线：1 步

591-50-4

_94%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Copper oxide (CuO) (silica supported) , Silica Solvents: Dimethyl sulfoxide ; 55 min, 120 °C

参考文献：

C-N cross-coupling reaction catalysed by efficient and reusable CuO/SiO2 nanoparticles under ligand-free conditions

Hajipour, Abdol R.; et al, Applied Organometallic Chemistry, 2014, 28(11), 809-813

合成路线：1 步

591-50-4

_93%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: Nickel ferrite Solvents: Water ; 25 min, 60 °C

参考文献：

C-N Bond Formation Using Highly Effective and Reusable Nickel Ferrite Nanoparticles in Water

Moghaddam, Firouz Matloubi; et al, ChemCatChem, 2014, 6(12), 3474-3481

合成路线：1 步

591-50-4

_92%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Palladium , 2256068-46-7 (palladium complexes) Solvents: Dimethylformamide ; 3 h, 100 °C

参考文献：

Design of BNPs-TAPC Palladium Complex as a Reusable Heterogeneous Nanocatalyst for the O-Arylation of Phenols and N-Arylation of Amines

Bahrami, Kiumars; et al, Catalysis Letters, 2019, 149(3), 688-698

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Copper Solvents: Methanol ; 7 min, 70 °C

参考文献：

Ligand Free Microwave Assisted Copper-Catalyzed Convenient Synthesis of Substituted Tertiary Amines from Nitroarenes

Karnik, Kshipra S.; et al, Current Microwave Chemistry, 2017, 4(3), 256-261

合成路线：1 步

108-90-7

_92%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Copper oxide (CuO) (silica supported) , Silica Solvents: Dimethyl sulfoxide ; 50 min, 120 °C

参考文献：

C-N cross-coupling reaction catalysed by efficient and reusable CuO/SiO2 nanoparticles under ligand-free conditions

Hajipour, Abdol R.; et al, Applied Organometallic Chemistry, 2014, 28(11), 809-813

合成路线：1 步

108-90-7

_90%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: Nickel ferrite Solvents: Water ; 45 min, 60 °C

参考文献：

C-N Bond Formation Using Highly Effective and Reusable Nickel Ferrite Nanoparticles in Water

Moghaddam, Firouz Matloubi; et al, ChemCatChem, 2014, 6(12), 3474-3481

合成路线：1 步

108-90-7

_86%

反应条件：

1.1 Reagents: Sodium tert-butoxide Catalysts: Dichlorobis(pyridine)nickel , 1H-Imidazolium, 1,3-bis[2,6-bis(1-methylethyl)phenyl]-, chloride (1:1) Solvents: o-Xylene ; 4 h, 150 °C

参考文献：

A Simple Protocol for the C-N Cross-Coupling of Aryl Chlorides with Amines Applying Ni/NHC Catalysis

Khazipov, Oleg V.; et al, ChemCatChem, 2023, 15(13),

合成路线：1 步

165280-70-6

_92%

反应条件：

1.1 Solvents: Dichloromethane ; 6 h, rt

参考文献：

A mild and catalyst-free aromatization using dihydroxylcyclohexanone derivatives as phenyl sources: a new approach to anilines

Luo, Jun; et al, Tetrahedron Letters, 2013, 54(34), 4505-4508

合成路线：1 步

66950-63-8

_91%