92-07-9 ((3,5-Diphenylpyridine)

_96%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: (SP-4-4)-Chloro[2-[1-[(4-methylphenyl)imino-κN]ethyl]ferrocenyl-κC](triphenylpho… Solvents: Ethanol , Water ; 4 h, 90 °C

参考文献：

Palladacycle-catalyzed Suzuki-Miyaura reaction of aryl/heteroaryl halides with MIDA boronates in EtOH/H2O or H2O

Li, Yabo; Wang, Jingran; Wang, Zhiwei; Huang, Mengmeng; Yan, Beiqi; et al, RSC Advances, 2014, 4(68), 36262-36266

合成路线：1 步

2457-47-8

_95%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 100 °C
1.2 Reagents: Polyaniline Catalysts: Palladium ; 6 h, 100 °C

参考文献：

Palladium nanoparticles supported on polyaniline nanofibers as a semi-heterogeneous catalyst in water

Gallon, Benjamin J.; Kojima, Robert W.; Kaner, Richard B.; Diaconescu, Paula L., Angewandte Chemie, 2007, 46(38), 7251-7254

合成路线：1 步

96-09-3

_94%

反应条件：

1.1 Catalysts: Scandium triflate Solvents: 1,4-Dioxane ; 15 min, rt
1.2 Reagents: Ammonia Catalysts: Iron chloride (FeCl3) Solvents: Tetrahydrofuran ; rt; 30 min, rt; rt → 110 °C; 24 h, 110 °C

参考文献：

Sc(OTf)3-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

Mehedi, Shafaat Al Md; George, Dare E. ; Tepe, Jetze J., Journal of Organic Chemistry, 2022, 87(24), 16820-16828

合成路线：1 步

53710-18-2

4406-72-8

_94%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Cupric chloride Solvents: Dimethylformamide ; 24 h, 110 °C
1.2 Solvents: Water ; 110 °C

参考文献：

Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates

Ranjani, Ganapathy; Nagarajan, Rajagopal, Organic Letters, 2017, 19(15), 3974-3977

合成路线：1 步

122-78-1

_93%

反应条件：

1.1 Reagents: Water , Ceric ammonium nitrate Catalysts: Acetic acid, 2,2,2-trifluoro-, copper(2+) salt (2:1) Solvents: Dimethylformamide ; 12 h, 80 °C

参考文献：

Cu-Catalyzed Concise Synthesis of Pyridines and 2-(1H)-Pyridones from Acetaldehydes and Simple Nitrogen Donors

Li, Ziyuan; Huang, Xiaoqiang; Chen, Feng; Zhang, Chun; Wang, Xiaoyang; et al, Organic Letters, 2015, 17(3), 584-587

合成路线：1 步

2064129-05-9

_92%

反应条件：

1.1 Reagents: Formic acid , Triethylamine Catalysts: Palladium diacetate , 1,3-Bis(diphenylphosphino)propane Solvents: Dimethylformamide ; 1 h, 60 °C; cooled
1.2 Reagents: Water ; cooled

参考文献：

Synthesis of Trisubstituted Pyridines via Chemoselective Suzuki-Miyaura Coupling of 3,5- and 4,6-Dibromo-2-tosyloxypyridines

Park, Cho-Hee; Kwon, Yong-Ju; Oh, In-Young; Kim, Won-Suk, Advanced Synthesis & Catalysis, 2017, 359(1), 107-119

合成路线：1 步

5153-67-3

_90%

反应条件：

1.1 Reagents: Iron Solvents: Acetic acid ; 30 min, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; neutralized

参考文献：

Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes

Sathish, Manda; Chetna, Jadala; Hari Krishna, Namballa; Shankaraiah, Nagula; Alarifi, Abdullah; et al, Journal of Organic Chemistry, 2016, 81(5), 2159-2165

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: 1-Hexanamine, N,N′-methanetetraylbis-, homopolymer (composite with palladium) Solvents: 1,4-Dioxane ; 19 h, reflux

参考文献：

Synthesis and catalytic activity of a poly(N,N-dialkylcarbodiimide)/palladium nanoparticle composite: a case in the Suzuki coupling reaction using microwave and conventional heating

Liu, Yubiao; Khemtong, Chalermchai; Hu, Jun, Chemical Communications (Cambridge, 2004, (4), 398-399

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Di-μ-chlorobis(η3-2-propenyl)dipalladium , rel-1,1′,1′′,1′′′-[(1R,2R,3S,4S)-1,2,3,4-Cyclopentanetetrayltetrakis(methylene)]… Solvents: Xylene ; 20 h, 130 °C

参考文献：

Reaction of aryl di-, tri-, or tetrabromides with arylboronic acids or alkenes in the presence of a palladium-tetraphosphine catalyst

Berthiol, Florian; Kondolff, Isabelle; Doucet, Henri; Santelli, Maurice, Journal of Organometallic Chemistry, 2004, 689(17), 2786-2798

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Ethanol ; 2 h, 65 °C

参考文献：

Fabrication and Application of Graphene Supported Diimine-Palladium Complex Catalyst for Organic Synthesis

Sun, Yunlong; Li, Tian, ChemistrySelect, 2020, 5(4), 1431-1438

合成路线：1 步

150-30-1

_83%

反应条件：

1.1 Reagents: Cupric acetate , Iron chloride (FeCl3) Catalysts: Palladium diacetate , 2′-(Dicyclohexylphosphino)-N,N-dimethyl[1,1′-biphenyl]-2-amine Solvents: Dimethyl sulfoxide , Dimethylformamide ; 16 h, 120 °C

参考文献：

Pd-Catalyzed Decarboxylation and Dual C(sp3)-H Functionalization Protocols for the Synthesis of 2,4-Diarylpyridines

Gujjarappa, Raghuram ; Vodnala, Nagaraju; Kumar, Mohan; Malakar, Chandi C., Journal of Organic Chemistry, 2019, 84(9), 5005-5020

合成路线：1 步

24388-23-6

_82%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran , Water ; rt; 12 h, 80 °C

参考文献：

Olefin Cyclopropanation by Radical Carbene Transfer Reactions Promoted by Cobalt(II)/Porphyrinates: Active-Metal-Template Synthesis of [2]Rotaxanes

Alcantara, Arthur F. P.; Fontana, Liniquer A.; Rigolin, Vitor H.; Andrade, Yuri F. S.; Ribeiro, Marcos A. ; et al, Angewandte Chemie, 2018, 57(29), 8979-8983

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Methanol , Acetonitrile ; 3.5 h, rt

参考文献：

Palladium nanoparticles catalyzed Suzuki cross-coupling reactions in ambient conditions

Mandali, Pavan Kumar; Chand, Dillip Kumar, Catalysis Communications, 2013, 31, 16-20

合成路线：1 步

36960-99-3

_82%

参考文献：

Alkaline cleavage of (1-phenylsulfonyl-2-pyrazolin-5-yl)methyl ketones and related compounds

Lempert-Sreter, M.; Lempert, K., Tetrahedron, 1975, 31(15), 1677-82

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Triphenylphosphine Solvents: Dimethylacetamide ; 12 h, 130 °C

参考文献：

Transition-Metal-Free Coupling Reactions: PPh3-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes

Tian, Wan-Fa; He, Ke-Han; Li, Na; Fen; Liu; et al, ChemistrySelect, 2020, 5(15), 4496-4499

合成路线：1 步

122-78-1

_80%

反应条件：

1.1 Reagents: Sodium bicarbonate , Ammonium acetate , Oxygen Solvents: 1,4-Dioxane ; 5 h, 90 °C

参考文献：

Metal-free synthesis of substituted pyridines from aldehydes and NH4OAC under air

Yan, Rulong; Zhou, Xiaoqiang; Li, Ming; Li, Xiaoni; Kang, Xing; et al, RSC Advances, 2014, 4(92), 50369-50372

合成路线：1 步

122-78-1

68-12-2

_78%

反应条件：

1.1 Reagents: Ammonium iodide Solvents: Dimethylformamide ; 6 h, 130 °C

参考文献：

Selective Synthesis of Substituted Pyridines and Pyrimidines through Cascade Annulation of Isopropene Derivatives

Li, Jian; Li, Jiaming; He, Runfa; Liu, Jiasheng; Liu, Yang; et al, Organic Letters, 2022, 24(8), 1620-1625

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Palladium, bis(6-methyl-α,α-diphenyl-2-pyridineethanolato-κN1,κO2)-, compd. with… Solvents: Ethanol ; 7 h, 50 °C

参考文献：

The catalytic activity of a novel recyclable alkoxypalladium complex in Suzuki reaction

Li, Yabo; Mi, Xia; Huang, Mengmeng; Cai, Ranran; Wu, Yangjie, Tetrahedron, 2012, 68(40), 8502-8508

合成路线：1 步

反应条件：

1.1 Reagents: Sulfolane , Cesium carbonate ; 24 h, 135 °C

参考文献：

Base-Promoted One-Pot Synthesis of Pyridine Derivatives via Aromatic Alkyne Annulation Using Benzamides as Nitrogen Source

Mehmood, Hina; Iqbal, Muhammad Asif; Ashiq, Muhammad Naeem; Hua, Ruimao, Molecules, 2021, 26(21),

合成路线：1 步

150-30-1

_75%