92288-93-2 (环戊二烯四氯化钼,Ethyl 2,4-Dioxo-4-(2-pyridinyl)butanoate)

_97%

反应条件：

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ; rt; 18 h, rt
1.2 Reagents: Acetic acid Solvents: Water ; neutralized, rt

参考文献：

Synthesis of a Library of Iridium-Containing Dinuclear Complexes with Bridging PNNN and PNNP Ligands (BL), [LM(μ-BL)M'L']BF4. 1. Specific Synthesis of Isomeric Heterodinuclear Complexes with Switched Metal Arrangements

Dubs, Christian; Yamamoto, Toshiki; Inagaki, Akiko; Akita, Munetaka, Organometallics, 2006, 25(6), 1344-1358

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sodium Solvents: Ethanol ; 14 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors

Wu, Yumeng; Tang, Chengrun; Rui, Ruomei; Yang, Liumeng; Ding, Wei; et al, Acta Pharmaceutica Sinica B, 2020, 10(3), 512-528

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ; 20 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Kim, Junwon; Lee, Doohyun; Park, Changmin; So, Wonyoung; Jo, Mina; et al, ACS Medicinal Chemistry Letters, 2012, 3(8), 678-682

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Toluene ; rt → 50 °C
1.2 Solvents: Toluene ; 50 °C; 15 min, reflux
1.3 Solvents: Ethanol ; reflux

参考文献：

Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase

Ma, Kaiqing; Wang, Penghui; Fu, Wei; Wan, Xiaolong; Zhou, Lu; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(22), 6724-6727

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Lithium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ; -78 °C; -78 °C; 1 h, rt
1.2 Reagents: Water

参考文献：

Preparation of pyrrolopyrazolones as modulators of FPR1 and methods of using the same

, World Intellectual Property Organization, , ,

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ; overnight, 0 °C → rt

参考文献：

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Beaulieu, Pierre L.; Gillard, James; Bykowski, Darren; Brochu, Christian; Dansereau, Nathalie; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(19), 4987-4993

合成路线：1 步

_31%

反应条件：

1.1 Reagents: Sodium methoxide Solvents: Ethanol ; 20 h, rt

参考文献：

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Mowbray, Charles E. ; Braillard, Stephanie; Glossop, Paul A. ; Whitlock, Gavin A.; Jacobs, Robert T. ; et al, Journal of Medicinal Chemistry, 2021, 64(21), 16159-16176

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 0 °C; 30 min, rt
1.2 0 °C; 18 h, rt

参考文献：

ATF6 inhibitors and uses thereof as therapeutic agents for treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer

, World Intellectual Property Organization, , ,

合成路线：1 步