925-83-7 (癸二酸二酰肼,Decanedihydrazide)

_99%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ; 3 s, 60 °C

参考文献：

Continuous preparation method of hydrazide using microchannel reactor or tubular reactor

, China, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Zinc chloride Solvents: Methanol ; 65 °C; 75 °C
1.2 Reagents: Hydrazine hydrate (1:1) Catalysts: Iron chloride (FeCl3) ; 75 °C; 80 °C

参考文献：

Synthetic method of dibasic acid dihydrazide from dibasic ester compound and hydrazine hydrate by two-step reaction

, China, , ,

合成路线：1 步

111-20-6

_96%

反应条件：

1.1 Reagents: Hydrazinecarboxylic acid ; 10 min, rt; 5 h, 100 °C

参考文献：

Method for the preparation of hydrazide

, Korea, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; 3 h, reflux

参考文献：

Synthesis of 2,2'-(1,8-octanediyl)bis[5-methyl-1,3,4-oxadiazole]

Zou, Chun-yang; Zhang, Quan; He, Lu; Fan, Ping, Liaoning Daxue Xuebao, 2005, 32(2), 108-110

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; rt; overnight, reflux

参考文献：

Novel fatty acid based di-isocyanates towards the synthesis of thermoplastic polyurethanes

More, Arvind S.; Lebarbe, Thomas; Maisonneuve, Lise; Gadenne, Benoit; Alfos, Carine; et al, European Polymer Journal, 2013, 49(4), 823-833

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; rt; 0 °C

参考文献：

Synthesis, characterization and biological activities of new bis-1,3,4-oxadiazoles

Malghe, Yuvraj S.; Thorat, Varsha V.; Chowdhary, Abhay S.; Bobade, Anil S., Journal of Chemical and Pharmaceutical Research, 2015, 7(6), 392-398

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; reflux

参考文献：

Synthesis of N,N'-bis(salicyloyl)sebacic acid dihydrazide

Cai, Jin; Chen, Lang-qiu; Guo, Qi; Gao, Qing-jiao, Hecheng Huaxue, 2009, 17(3), 354-356

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; 72 h, 80 °C

参考文献：

''In Water'' Fabricated and Recycled Covalent Adaptable Acylhydrazone Thermosets

Li, Guanglong; Huang, Jing; Zhang, Xuhui; Wang, Yang; Qiao, Jinliang; et al, Macromolecular Materials and Engineering, 2023, 308(3),

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Hydrazine Solvents: Methanol ; 4 h, reflux

参考文献：

Structure-property relationship of thermoplastic polyurethane cationomers carrying quaternary ammonium groups

Borah, Kashmiri; Palanisamy, Aruna; Narayan, Ramanuj; Satapathy, Sukanya; Dileepkumar, Veeragoni; et al, Reactive & Functional Polymers, 2022, 181,

合成路线：1 步

111-20-6

_80%

反应条件：

1.1 Reagents: Thionyl chloride ; 20 min, reflux
1.2 Reagents: Hydrazine hydrate (1:1) ; cooled
1.3 Reagents: Ammonium hydroxide Solvents: Water ; basified

参考文献：

Synthesis, structural study and antimicrobial screening of bridgehead nitrogen containing 1,8-bis-thiadiazino-triazolyl-octanes

Kharate, Rajesh M.; Deohate, Pradip P.; Berad, B. N., Pharma Chemica, 2012, 4(6), 2434-2437

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Hydrazine Solvents: Methanol ; reflux

参考文献：

Synthesis of series of bis(1,4-diacylthiosemicarbazide)

Yang, Haijun; Yan, Jiang; Yi, Yunxia; Wu, Jiang, Huaxue Yanjiu Yu Yingyong, 2002, 14(3), 325-327

合成路线：1 步

_68%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; 5 h, reflux

参考文献：

Synthesis and anticonvulsant, antimicrobial activity of some bis-1,3,4-oxadiazole and bis-1,2,4-triazole derivatives from sebacic acid

Patil, S. G.; Girisha, M.; Badiger, Jaishree; Kudari, S. M.; Purohit, M. G., Indian Journal of Heterocyclic Chemistry, 2007, 17(1), 37-40

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; 2 h, reflux

参考文献：

Structural and antimicrobial studies of some newly synthesized dihydrazones

Kumar, Devendra; Singh, Rohini, Acta Ciencia Indica, 2010, 36(2), 173-176

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Hydrazine Solvents: Ethanol ; 72 h, 80 °C

参考文献：

Hydrazone bond enhance the mechanical properties, heating resistance, and water resistance of imine-based thermosets

Li, Guanglong; Zhang, Xuhui; Huang, Jing; Li, Ting; Yang, Shuobing; et al, Chemical Engineering Journal (Amsterdam, 2022, 435,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol , Water ; 6 h, reflux

参考文献：

Aldehyde emission reduction for dibenzylidene sorbitol clarified plastics

, World Intellectual Property Organization, , ,

合成路线：1 步

111-20-6

反应条件：

1.1 Reagents: Thionyl chloride , Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ; 12 h, 10 °C; 72 h, 40 °C

参考文献：

Preparation method of thermosetting resin with double dynamic covalent bond hybridization and repair cycle recycling method

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; reflux

参考文献：

Improved protocol toward 1,3,4-oxadiazole-2(3H)-thiones and scale-up synthesis in the presence of SDS as a Micelle promoted catalyst

Yildirim, Ayhan, Acta Chimica Slovenica, 2015, 62(2), 473-478

合成路线：1 步

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol , Water ; 2 h, 60 °C

参考文献：

Polyacetal resin compositions with low thermal decomposition during continuous extrusion and manufacture thereof

, Japan, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ; 2 h, reflux; overnight, reflux → rt

参考文献：

Structural assignment and antimicrobial evaluation of newly synthesized macrocyclic complexes derived from dihydrazide

Kumar, Devendra; Varshney, Swati; Sharma, Shivangi, Acta Ciencia Indica, 2009, 35(1), 81-85

合成路线：1 步