92-92-2 (联苯-4-羧酸,4-Biphenylcarboxylic acid)

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Water ; 24 h, 27 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Gold/Palladium Alloy for Carbon-Halogen Bond Activation: An Unprecedented Halide Dependence

Dhital, Raghu Nath; Bobuatong, Karan; Ehara, Masahiro; Sakurai, Hidehiro, Chemistry - An Asian Journal, 2015, 10(12), 2669-2676

合成路线：1 步

3218-36-8

_100%

反应条件：

1.1 Reagents: Methanesulfinic acid, 1,1,1-trifluoro-, sodium salt (1:1) , Oxygen Solvents: Acetonitrile ; 12 h, 1 atm, rt

参考文献：

Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photocatalytic oxidation method therefor

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Ethanol , Water ; 1 h, 60 °C

参考文献：

Ligand-free, recyclable palladium-functionalized magnetite nanoparticles as a catalyst in the Suzuki-, Sonogashira, and Stille reaction

De Cattelle, Amaury; Billen, Arne; O'Rourke, Galahad; Brullot, Ward; Verbiest, Thierry; et al, Journal of Organometallic Chemistry, 2019, 904,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium (magnetic ionic nanoparticle network-supported) Solvents: Ethanol , Water ; 2 h, 75 °C

参考文献：

Nanopalladium on Magnetic Ionic Nanoparticle Network (MINN) as an Efficient and Recyclable Catalyst with High Ionic Density and Dispersibility

Karimi, Babak; Tavakolian, Mina ; Mansouri, Fariborz; Vali, Hojatollah, ACS Sustainable Chemistry & Engineering, 2019, 7(4), 3811-3823

合成路线：1 步

3597-91-9

_100%

反应条件：

1.1 Reagents: Oxygen Catalysts: Manganese carbonate , Zinc oxide (ZnO) , Graphene (oxide, reduced) Solvents: Toluene ; 11 min, 100 °C

参考文献：

Mixed zinc/manganese on highly reduced graphene oxide: a highly active nanocomposite catalyst for aerial oxidation of benzylic alcohols

Assal, Mohamed E.; Shaik, Mohammed Rafi; Kuniyil, Mufsir; Khan, Mujeeb; Alzahrani, Abdulrahman Yahya; et al, Catalysts, 2017, 7(12),

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Water ; 0.25 h, 80 °C

参考文献：

Catalytic polymeric nanocomposites via cucurbit[n]uril host-guest interactions

Wu, Yuchao; Lan, Yang; Liu, Ji; Scherman, Oren A., Nanoscale, 2015, 7(32), 13416-13419

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Palladium , Silica Solvents: Water ; 1 h, 110 °C

参考文献：

Palladium Nanoparticles Supported on Mesoporous Silica as Efficient and Recyclable Heterogenous Nanocatalysts for the Suzuki C-C Coupling Reaction

Ncube, Phendukani; Hlabathe, Thaane; Meijboom, Reinout, Journal of Cluster Science, 2015, 26(5), 1873-1888

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: 1604839-72-6 (silica-coated iron oxide-bound) Solvents: Water ; 6 h, rt → 60 °C

参考文献：

A highly water-dispersible/magnetically separable palladium catalyst based on a Fe3O4@SiO2 anchored TEG-imidazolium ionic liquid for the Suzuki-Miyaura coupling reaction in water

Karimi, Babak; Mansouri, Fariborz; Vali, Hojatollah, Green Chemistry, 2014, 16(5), 2587-2596

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: 1,4-Benzenediamine, polymer with 1,3,5-triisocyanatobenzene (palladium complexes) Solvents: Water ; 3 h, 60 °C

参考文献：

Urea-Based Porous Organic Frameworks: Effective Supports for Catalysis in Neat Water

Li, Liuyi; Chen, Zhilin; Zhong, Hong; Wang, Ruihu, Chemistry - A European Journal, 2014, 20(11), 3050-3060

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: 1590342-82-7 Solvents: Dimethylformamide , Water ; 24 h, 100 - 110 °C

参考文献：

Efficient catalysis of Suzuki-Miyaura CC coupling reactions with palladium(II) complexes of partially hydrolyzed bisimine ligands: A process important in environment context

Kumar, Arun; Rao, Gyandshwar Kumar; Saleem, Fariha; Kumar, Rupesh; Singh, Ajai K., Journal of Hazardous Materials, 2014, 269, 9-17

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Water ; 4 h, 100 °C

参考文献：

Palladium(II)-(E,N,E) pincer ligand (E = S/Se/Te) complex catalyzed Suzuki coupling reactions in water via in situ generated palladium quantum dots

Kumar, Satyendra; Rao, Gyandshwar K.; Kumar, Arun; Singh, Mahabir P.; Singh, Ajai Kumar, Dalton Transactions, 2013, 42(48), 16939-16948

合成路线：1 步

720-75-2

_100%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran , Water ; 12 h, rt
1.2 Reagents: Sodium bisulfate ; pH 1, rt

参考文献：

Preparation of pyrrolidinyl carboxamides as fatty acid synthase inhibitors for treating cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

619-42-1

_100%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: (SP-4-4)-[4-[[2-[[[2-(Hydroxy-κO)-4-hydroxyphenyl]methylene]amino-κN]ethyl]imino… Solvents: Toluene , Water ; 24 h, 90 °C

参考文献：

Polymer-supported palladium catalysts for Suzuki and Heck reactions

Styring, Peter, Solid-Phase Organic Syntheses, 2012, 2, 69-78

合成路线：1 步

14047-29-1

108-86-1

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: (SP-4-2)-[1,1′-Bis[bis(1,1-dimethylethyl)phosphino-κP]ferrocene]dichloropalladiu… Solvents: Acetonitrile , Water ; 1 - 2 h, 60 °C

参考文献：

A mild robust generic protocol for the Suzuki reaction using an air stable catalyst

Moseley, Jonathan D.; Murray, Paul M.; Turp, Edward R.; Tyler, Simon N. G.; Burn, Ross T., Tetrahedron, 2012, 68(30), 6010-6017

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium hydroxide , Tetrabutylammonium bromide Catalysts: Palladium (complexes with hexylimidazolium-functionalized styrene-vinylbenzyl chloride copolymer) Solvents: Water ; 1.5 h, 120 °C

参考文献：

Palladium nanoparticles immobilized by click ionic copolymers: Efficient and recyclable catalysts for Suzuki-Miyaura cross-coupling reaction in water

Zhang, Dong; Zhou, Chunshan; Wang, Ruihu, Catalysis Communications, 2012, 22, 83-88

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Trisodium phosphate Catalysts: Palladium , Diaion HP 20 Solvents: Water ; 6 h, rt

参考文献：

Carbon-Carbon Bond Formation by Ligand-free Cross-Coupling Reaction Using Palladium Catalyst Supported on Synthetic Adsorbent

Monguchi, Yasunari; Sakai, Keita; Endo, Koichi; Fujita, Yuki; Niimura, Masaru; et al, ChemCatChem, 2012, 4(4), 546-558

合成路线：1 步

1124-19-2

_100%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Palladium , L-Threonyl-L-seryl-L-asparaginyl-L-alanyl-L-valyl-L-histidyl-L-prolyl-L-threonyl… (palladium nanoparticle surface functionalized with) Solvents: Water ; 24 h, rt
1.2 rt

参考文献：

Interrogating the catalytic mechanism of nanoparticle mediated Stille coupling reactions employing bio-inspired Pd nanocatalysts

Pacardo, Dennis B.; Slocik, Joseph M.; Kirk, Kyle C.; Naik, Rajesh R.; Knecht, Marc R., Nanoscale, 2011, 3(5), 2194-2201

合成路线：1 步

3315-91-1

124-38-9

_100%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 42 s, 4 atm, rt
1.2 Reagents: Ammonium hydroxide ; rt
1.3 Reagents: Formic acid Solvents: Tetrahydrofuran

参考文献：

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

Polyzos, Anastasios; O'Brien, Matthew; Petersen, Trine P.; Baxendale, Ian R.; Ley, Steven V., Angewandte Chemie, 2011, 50(5), 1190-1193

合成路线：1 步

1124-19-2

_100%