93-11-8 (2-萘磺酰氯,Naphthalene-2-sulfonyl chloride)

_100%

反应条件：

1.1 Reagents: Thionyl chloride

参考文献：

Synthesis of some naphthalene sulfonohydrazides and related compounds of potential biological activity

Islam, A. M.; Abdel-Halim, A. M.; Salama, M. A., Egyptian Journal of Chemistry, 1987, 29(4), 405-31

合成路线：1 步

16023-36-2

_100%

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide

参考文献：

A method for the catalyzed preparation of carboxylic and sulfonic acid chlorides with thionyl chloride

Bosshard, H. H.; Mory, R.; Schmid, M.; Zollinger, Hch., Helvetica Chimica Acta, 1959, 42, 1653-8

合成路线：1 步

10151-46-9

_99%

反应条件：

1.1 Reagents: Chlorosuccinimide Solvents: Acetonitrile ; 2 h, rt

参考文献：

Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides

Chen, Rongxiang; Xu, Shaohong; Shen, Fumin; Xu, Canran; Wang, Kaikai ; et al, Molecules, 2021, 26(18),

合成路线：1 步

5586-15-2

_98%

反应条件：

1.1 Reagents: Potassium chloride , Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Water ; 15 min, rt

参考文献：

Oxyhalogenation of thiols and disulfides into sulfonyl chlorides/bromides using oxone-KX (X = Cl or Br) in water

Madabhushi, Sridhar; Jillella, Raveendra; Sriramoju, Vinodkumar; Singh, Rajpal, Green Chemistry, 2014, 16(6), 3125-3131

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Trichloroisocyanuric acid , Tetrabutylammonium chloride Solvents: Acetonitrile , Water ; 1 - 2 min, 0 °C; 20 min, rt

参考文献：

Trichloroisocyanuric acid (TCCA) and N-chlorosuccinimide (NCS) as efficient reagents for the direct oxidative conversion of thiols and disulfides to sulfonyl chlorides

Veisi, Hojat; Sedrpoushan, Alireza; Hemmati, Saba; Kordestani, Davood, Phosphorus, 2012, 187(6), 769-775

合成路线：1 步

5586-15-2

_98%

反应条件：

1.1 Reagents: Tetrabutylammonium chloride , N1,N1,N3,N3-Tetrachloro-1,3-benzenedisulfonamide Solvents: Acetonitrile , Water ; 1 - 2 min, 0 °C; 0 °C → rt; 20 min, rt

参考文献：

Poly(N,N'-dichloro-N-ethyl-benzene-1,3-disulfonamide) and N,N,N',N'-tetrachlorobenzene-1,3-disulfonamide as efficient reagents to direct oxidative conversion of thiols and disulfide to sulfonyl chlorides

Veisi, Hojat; Ghorbani-Vaghei, Ramin; Mahmoodi, Jafar, Bulletin of the Korean Chemical Society, 2011, 32(10), 3692-3695

合成路线：1 步

5586-15-2

_98%

反应条件：

1.1 Reagents: Hydrogen peroxide , Zirconium chloride (ZrCl4) Solvents: Acetonitrile , Water ; < 1 min, 25 °C

参考文献：

A novel, practical synthesis of sulfonyl chlorides from thiol and disulfide derivatives

Bahrami, Kiumars; Khodaei, Mohammad Mehdi; Soheilizad, Mehdi, Synlett, 2009, (17), 2773-2776

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Hexachlorocyclotriphosphazene , Hydrogen peroxide Solvents: Acetonitrile , Water ; 12 min, 25 °C

参考文献：

A Practical Method for the Preparation of Sulfonyl Chlorides and Sulfonamides from Thiols using H2O2-TAPC Reagent System

Parnian, Rouhallah; Soleimani, Ebrahim; Bahrami, Kiumars, ChemistrySelect, 2019, 4(29), 8554-8557

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Thionyl chloride , Hydrogen peroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C
1.2 Reagents: Water Solvents: Water

参考文献：

Direct Conversion of Thiols to Sulfonyl Chlorides and Sulfonamides

Bahrami, Kiumars; Khodaei, Mohammad M.; Soheilizad, Mehdi, Journal of Organic Chemistry, 2009, 74(24), 9287-9291

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Acetic acid , Diethylamine , 1,3-Dichloro-5,5-dimethylhydantoin , Water Solvents: Acetonitrile ; 41 s, 4 bar, 40 °C
1.2 Reagents: Acetonitrile

参考文献：

A continuous flow investigation of sulfonyl chloride synthesis using N-chloroamides: optimization, kinetics and mechanism

Polterauer, Dominik; Roberge, Dominique M.; Hanselmann, Paul; Littich, Ryan; Hone, Christopher A.; et al, Reaction Chemistry & Engineering, 2022, 7(12), 2582-2592

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Phosphorus oxychloride ; 6 h, 70 °C

参考文献：

Method for synthesis of 2-naphthalenesulfonyl chloride from sodium 2-naphthalenesulfonate and phosphorus oxychloride

, China, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium dodecyl sulfate , Hydrogen peroxide , Phosphorus oxychloride Solvents: Water ; 40 min, 25 °C

参考文献：

Synthesis of sulfonyl chlorides and sulfonic acids in SDS micelles

Bahrami, Kiumars; Khodaei, Mohammad M.; Abbasi, Jamshid, Synthesis, 2012, 44(2), 316-322

合成路线：1 步

120-18-3

_94%

反应条件：

1.1 Reagents: Hexachlorocyclotriphosphazene ; 1 min, 25 °C
1.2 Reagents: Potassium chloride ; 1 min, 25 °C

参考文献：

TAPC-promoted synthesis of sulfonyl chlorides from sulfonic acids

Bahrami, Kiumars, Synlett, 2011, (18), 2671-2674

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Chlorotrimethylsilane , Hydrogen peroxide Solvents: Acetonitrile , Water ; 3 min, rt

参考文献：

High yielding protocol for direct conversion of thiols to sulfonyl chlorides and sulfonamides

Sohrabnezhad, Samira; Bahrami, Kiumars; Hakimpoor, Farahman, Journal of Sulfur Chemistry, 2019, 40(3), 256-264

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Titanium tetrachloride , Hydrogen peroxide Solvents: Acetonitrile , Water ; 2 min, 25 °C
1.2 Reagents: Water ; rt

参考文献：

Synthesis of sulfonyl chlorides and thiosulfonates from H2O2-TiCl4

Bahrami, Kiumars; Khodaei, Mohammad M.; Khaledian, Donya, Tetrahedron Letters, 2012, 53(3), 354-358

合成路线：1 步

580-13-2

_92%

反应条件：

1.1 Solvents: Tetrahydrofuran
1.2 Reagents: Butyllithium , Sulfur dioxide Solvents: Tetrahydrofuran
1.3 Reagents: Sulfuryl chloride Solvents: Hexane

参考文献：

An improved synthesis of arenesulfonyl chlorides from aryl halides

Hamada, Tatsuo; Yonemitsu, Osamu, Synthesis, 1986, (10), 852-4

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Cyanuric chloride Catalysts: 18-Crown-6 Solvents: Acetone ; 20 h, reflux

参考文献：

A new, mild preparation of sulfonyl chlorides

Blotny, Grzegorz, Tetrahedron Letters, 2003, 44(7), 1499-1501

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Acetic acid , 1,3-Dichloro-5,5-dimethylhydantoin Solvents: Acetonitrile , Water ; < 10 °C; 30 min, 10 °C → 20 °C; 1 h, 20 °C; 30 °C
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane ; 0 °C; < 10 °C; 15 min, 5 °C

参考文献：

A simple and highly effective oxidative chlorination protocol for the preparation of arenesulfonyl chlorides

Pu, Yu-Ming; Christesen, Alan; Ku, Yi-Yin, Tetrahedron Letters, 2010, 51(2), 418-421

合成路线：1 步

16023-36-2

_82%

参考文献：

Molecular structure and estrogenic activity. XIV. α,α-Dimethyl-β-(6-methylthio-2-naphthyl)valeric acid

Jacques, Jean, Bulletin de la Societe Chimique de France, 1955, 231, 231-6

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Phosphorus pentachloride , Calcium chloride ; 1 h, 100 °C

参考文献：

Polymer side-chain modification in methacrylate and styrene copolymers through thiol-thioester dynamic exchange

Fila, Karolina; Goliszek, Marta; Podkoscielna, Beata; Podgorski, Maciej, European Polymer Journal, 2020, 136,

合成路线：1 步

91-20-3