93-27-6 (邻甲氧基对硝基乙酰苯胺,N-(2-Methoxy-4-nitrophenyl)acetamide)

_99%

反应条件：

1.1 Solvents: Acetic acid ; rt → 90 °C; 90 °C; 2 h, 90 °C; 90 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; neutralized, cooled

参考文献：

The synthesis of 3,3'-dimethoxy-4,4'-diamine azobenzene

Shen, Yan-hang; Li, Sheng-hui; Tang, Chan; Li, Ji-tai, Guangzhou Huagong, 2010, 38(3), 51-52

合成路线：1 步

_97%

反应条件：

1.1 Solvents: Acetic acid

参考文献：

Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921

Brennan, Sean T.; Colbry, Norman L.; Leeds, Robert L.; Leja, Boguslawa; Priebe, Stephen R.; et al, Journal of Heterocyclic Chemistry, 1989, 26(5), 1469-76

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sulfuric acid , Nitric acid Solvents: Dichloromethane , Water ; 5.9 min, 30 °C

参考文献：

Cost-effective preparation of 2-methoxy-4-nitroacetanilide in continuous flow reactor

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Nitric acid Solvents: Water ; 2 min, 60 °C

参考文献：

Continuous preparation method of 2-acetylamino-5-nitroanisole

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Pyridine Solvents: Pyridine ; 2 h, 120 °C

参考文献：

Ratiometric fluorescent sensor based on inhibition of resonance for detection of cadmium in aqueous solution and living cells

Xue, Lin; Li, Guoping; Liu, Qing; Wang, Huanhuan; Liu, Chun; et al, Inorganic Chemistry, 2011, 50(8), 3680-3690

合成路线：1 步

_81%

反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Acetic acid ; overnight, reflux; cooled
1.2 Reagents: Water ; cooled

参考文献：

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead

Mologni, Luca; Dalla Via, Martina; Chilin, Adriana; Palumbo, Manlio; Marzaro, Giovanni, ChemMedChem, 2017, 12(16), 1390-1398

合成路线：1 步

75-36-5

_74%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; 8 h, rt

参考文献：

Preparation of pyridine derivatives having TTK protein kinase inhibition activity

, World Intellectual Property Organization, , ,

合成路线：1 步

64-19-7

_56%

反应条件：

1.1 -
1.2 Solvents: Ethyl acetate
1.3 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Liquid phase acylation of amines with acetic acid over HY zeolite

Narender, N.; Srinivasu, P.; Kulkarni, S. J.; Raghavan, K. V., Green Chemistry, 2000, 2(3), 104-105

合成路线：1 步

反应条件：

1.1 Reagents: Sodium pyrosulfite , Nitric acid Solvents: 1,2-Dichloroethane ; 0.9 min, 47 °C; 0.9 min, 0 - 5 °C

参考文献：

Method for continuous synthesizing N-(2-methoxy-4-nitrophenyl)acetamide

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Nitric acid Solvents: Acetic acid ; 5 s, 3.5 bar, 60 °C

参考文献：

Continuous flow production process of organic dye fast red B (2-methoxy-4-nitroaniline)

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Fuming nitric acid ; 1 h, 0 - 10 °C; 2 h, 0 - 10 °C

参考文献：

Preparation method of 2-methoxy-4-nitroaniline

, China, , ,

合成路线：1 步

参考文献：

Ozone-mediated reaction of anilides and phenyl esters with nitrogen dioxide: enhanced ortho-reactivity and mechanistic implications

Suzuki, Hitomi; Tatsumi, Atsuo; Ishibashi, Taro; Mori, Tadashi, Journal of the Chemical Society, 1995, (4), 339-43

合成路线：1 步

参考文献：

Nitroaminobenzenes

, United States, , ,

合成路线：1 步

参考文献：

Nitration of aromatic compounds with nitric acid in inert solvents

Kameo, Takashi; Hirashima, Tsuneaki, Kagaku to Kogyo (Osaka, 1985, 59(2), 49-53

合成路线：1 步

参考文献：

Interaction of 4-(9-acridinylamino)aniline and derivatives with DNA. Influence of a lysylglycyl side chain on the binding parameters

Henichart, Jean Pierre; Bernier, Jean Luc; Catteau, Jean Pierre, Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1982, 363(8), 835-41

合成路线：1 步

33721-54-9

反应条件：

1.1 Reagents: Nitric acid Solvents: Acetic acid , Water ; 60 s, 5.5 bar, 80 °C

参考文献：

Efficient separation process in preparation of fast red B, and its application in printing and dyeing industry

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Bismuth nitrate Solvents: Dichloromethane ; 1 - 5 h, 23 °C; 23 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride

Lu, Yang; Li, Yaming; Zhang, Rong; Jin, Kun; Duan, Chunying, Tetrahedron, 2013, 69(45), 9422-9427

合成路线：1 步