934266-82-7 (5-溴-2-氨基噻唑[5,4-B]并吡啶,5-Bromothiazolo5,4-bpyridin-2-amine)

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 1 h, reflux; reflux → rt
1.2 pH 10

参考文献：

Pyridinylbenzothiazole-urea derivatives as phosphatidylinositol 3-kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Acetic acid Solvents: Acetic acid ; 15 min, rt
1.2 Reagents: Acetic acid , Bromine Solvents: Acetic acid ; > 30 min, rt; 6 h, rt

参考文献：

Preparation of heterocyclic compounds as Raf inhibitors for treatment of cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

_77%

反应条件：

1.1 Solvents: Acetic acid ; -5 °C; -5 °C → -15 °C
1.2 Reagents: Acetic acid , Bromine Solvents: Acetic acid ; -15 °C; 12 h, -15 °C → rt

参考文献：

Preparation of thiazolo[5,4-b]pyridine derivatives as apoptosis signal-regulating kinase 1 inhibitors

, United States, , ,

合成路线：1 步

_69%

反应条件：

1.1 Solvents: Acetic acid ; 15 min, rt
1.2 Reagents: Bromine Solvents: Acetic acid ; 15 min, rt; 3 h, rt
1.3 Reagents: Water ; rt
1.4 Reagents: Sodium bicarbonate Solvents: Water ; pH 7, rt

参考文献：

Preparation of thiazolopyridine derivatives as GPR119 agonists for treatment of metabolic disorders

, World Intellectual Property Organization, , ,

合成路线：1 步

_68%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid ; rt; 15 h, rt

参考文献：

Preparation of tricyclic PI3K inhibitor compounds and methods of use thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_61%

反应条件：

1.1 Solvents: Acetic acid ; -5 °C
1.2 Reagents: Bromine Solvents: Acetic acid ; -15 °C; < 10 °C; 10 °C → rt; overnight, rt

参考文献：

Preparation of thiazolopyridinylacetamide derivatives and analogs for use as PI3K and mTOR kinase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid ; 0 °C; 0 °C → -5 °C; < 10 °C; 10 °C → rt; overnight, rt

参考文献：

Design, synthesis, and biological evaluation of triazole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors

Pan, Xiaoyan ; Liu, Nanxin; Liu, Yuying; Zhang, Qingqing; Wang, Kai; et al, European Journal of Medicinal Chemistry, 2022, 238,

合成路线：1 步

_51%

反应条件：

1.1 Solvents: Acetic acid ; 0 °C; 0 °C → -5 °C; -5 °C; < 10 °C; 10 °C → 25 °C; 12 h, 25 °C

参考文献：

Thiazolopyridine ring-linked triazole compound in preparation of Bcr-Ab1 tyrosine kinase inhibitor and antitumor drug and preparation method thereof

, China, , ,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid ; 30 min, 0 °C; 0 °C → rt; 16 h, rt
1.2 Reagents: Water ; 20 min, 85 °C

参考文献：

Preparation of Quinuclidine, 1-azabicyclo[2.2.1]heptane, 1-azabicyclo [3.2.1]octane, and 1-azabicyclo[3.2.2]nonane compounds as alpha-7 nicotinic acetylcholine receptor ligands

, World Intellectual Property Organization, , ,

合成路线：1 步

_50%