935-99-9 (2-溴-5-氯苯乙酮,1-(2-bromo-5-chlorophenyl)ethan-1-one)

_97%

反应条件：

1.1 Solvents: Diethyl ether , Tetrahydrofuran ; 30 min, 0 °C; 0 °C → rt; overnight, rt

参考文献：

Base-Catalyzed Synthesis of Substituted Indazoles under Mild, Transition-Metal-Free Conditions

Thome, Isabelle; Besson, Claire; Kleine, Tillmann; Bolm, Carsten, Angewandte Chemie, 2013, 52(29), 7509-7513

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Silica , Pyridinium chlorochromate Solvents: Dichloromethane ; rt

参考文献：

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Chang, Xin; Ma, Pei-Long; Chen, Hong-Chao; Li, Chuan-Ying; Wang, Peng, Angewandte Chemie, 2020, 59(23), 8937-8940

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Dess-Martin periodinane Solvents: Dichloromethane ; 45 min, rt

参考文献：

Direct synthesis of 1-naphthylamines enabled by 6-endo-dig cyclization strategy using copper catalysis

Ma, Peng ; Wang, Jianhui ; Liu, Guiyan, Applied Organometallic Chemistry, 2022, 36(6),

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Manganese oxide (MnO2) Solvents: Chloroform ; 18 h, reflux

参考文献：

One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis

Faggyas, Reka J.; Calder, Ewen D. D.; Wilson, Claire; Sutherland, Andrew, Journal of Organic Chemistry, 2017, 82(21), 11585-11593

合成路线：1 步

_69%

反应条件：

1.1 Reagents: Dess-Martin periodinane Solvents: Dichloromethane ; 0 - 5 °C; 3 h, rt
1.2 Reagents: Sodium bicarbonate , Sodium thiosulfate Solvents: Dichloromethane , Water ; rt; 1 h, rt

参考文献：

Preparation of boron containing fungicides and their use in compositions and methods for the control and/or prevention of microbial infection in plants

, World Intellectual Property Organization, , ,

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Dimethyl sulfoxide , Triethylamine ; rt; rt → 0 °C
1.2 Reagents: Sulfur trioxide-pyridine ; 0 °C; 16 h, 0 °C → rt
1.3 Reagents: Sodium chloride Solvents: Water

参考文献：

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction

Shuler, Scott A.; Yin, Guoyin; Krause, Sarah B.; Vesper, Caroline M.; Watson, Donald A., Journal of the American Chemical Society, 2016, 138(42), 13830-13833

合成路线：1 步

106-39-8

75-36-5

_50%

反应条件：

1.1 Reagents: Aluminum chloride

参考文献：

Behavior of three bromochlorobenzenes in Friedel-Crafts acylation reactions

Cam-Van, N. T.; Diep, Bui K.; Buu-Hoi N. P., Tetrahedron, 1964, 20(10), 2195-9

合成路线：1 步

反应条件：

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ; 6 h, rt

参考文献：

Palladium-Catalyzed Suzuki Coupling and NIS-Mediated Dehydrogenative Cycloetherification: A Concise Approach to 6,6-Disubstituted 6H-benzo[c]chromenes and Total Synthesis of Didehydroconicol

Shekhar, Chander; Satyanarayana, Gedu, European Journal of Organic Chemistry, 2022, 2022(18),

合成路线：1 步

反应条件：

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ; rt; 3 h, rt

参考文献：

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

Yoon, Wan Seok; Han, Jung Tae; Yun, Jaesook, Advanced Synthesis & Catalysis, 2021, 363(21), 4953-4959

合成路线：1 步

反应条件：

1.1 Reagents: Silica , Pyridinium chlorochromate Solvents: Dichloromethane ; rt

参考文献：

The intramolecular reaction of acetophenone N-tosylhydrazone and vinyl: Bronsted acid-promoted cationic cyclization toward polysubstituted indenes

Wang, Zhixin; Li, Yang; Chen, Fan; Qian, Peng-Cheng; Cheng, Jiang, Chemical Communications (Cambridge, 2021, 57(14), 1810-1813

合成路线：1 步

反应条件：

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ; 0 °C → rt; rt

参考文献：

Asymmetric synthesis of 1,2-dihydronaphthalene-1-ols via copper catalyzed intramolecular reductive cyclization

Acharyya, Ranjan Kumar; Kim, Soyoung; Park, Yeji; Han, Jung Tae; Yun, Jaesook, Organic Letters, 2020, 22(20), 7897-7902

合成路线：1 步

反应条件：

1.1 Reagents: Silica , Pyridinium chlorochromate Solvents: Dichloromethane ; 2 h, rt

参考文献：

PdII-Catalyzed Oxidative Tandem aza-Wacker/Heck Cyclization for the Construction of Fused 5,6-Bicyclic N,O-Heterocycles

Ye, Chenghao; Kou, Xuezhen; Xia, Jingzhao; Yang, Guoqiang ; Kong, Li; et al, Chemistry - An Asian Journal, 2018, 13(15), 1897-1901

合成路线：1 步

21739-93-5

反应条件：

1.1 Solvents: Diethyl ether ; 0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Enantioselective Bromo-oxycyclization of Silanol

Xia, Zilei; Hu, Jiadong; Shen, Zhigao; Wan, Xiaolong; Yao, Qizheng; et al, Organic Letters, 2016, 18(1), 80-83

合成路线：1 步

反应条件：

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ; 2 h, rt

参考文献：

Palladium-Catalyzed Aerobic Aminooxygenation of Alkenes for Preparation of Isoindolinones

Kou, Xuezhen; Li, Yu; Wu, Liang; Zhang, Xinghua; Yang, Guoqiang; et al, Organic Letters, 2015, 17(22), 5566-5569

合成路线：1 步

106-39-8

75-36-5

参考文献：

Synthesis of 2,3-dihydro-1H-isoindole-1-thiones via the bromine-lithium exchange between 1-bromo-2-(1-isothiocyanatoalkyl)benzenes and butyllithium

Kobayashi, Kazuhiro; Yokoi, Yuki; Nakahara, Tatsuya; Matsumoto, Naoki, Tetrahedron, 2013, 69(48), 10304-10310

合成路线：1 步

455957-87-6

反应条件：

1.1 Solvents: Toluene , Tetrahydrofuran ; 0 °C; 1 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 10 min, 0 °C

参考文献：

Acylated piperidine derivatives, specifically 1-(pyrrolidinylcarbonyl)piperidines, 1-(piperidinylcarbonyl)piperidines, and analogs, as melanocortin-4 receptor agonists, and their pharmaceutical compositions and therapeutic uses

, World Intellectual Property Organization, , ,

合成路线：1 步

455957-87-6

反应条件：

1.1 Solvents: Toluene , Tetrahydrofuran ; 1 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 10 min
1.3 Reagents: Water

参考文献：

Acylated piperidine derivatives, specifically 1-[(aminocycloalkyl)carbonyl]piperidines, as melanocortin-4 receptor agonists, and their pharmaceutical compositions and therapeutic uses

, World Intellectual Property Organization, , ,

合成路线：1 步