93635-76-8 (2-C-甲基-4,5-O-（异亚丙基）-D-阿糖酸乙基酯,ethyl (2S,3R)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,3-dihydroxy-2-methylpropanoate)

_93%

反应条件：

1.1 Catalysts: 1H-Imidazolium, 1,3-didodecyl-2-methyl-, chloride (1:1) Solvents: Acetone ; 10 min, rt; rt → 0 °C
1.2 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) ; 2 h, 0 - 5 °C
1.3 Reagents: Sodium bisulfite Solvents: Water

参考文献：

Dihydroxylation of Olefins with Potassium Permanganate Catalyzed by Imidazolium Salt

Khan, Imran; Luo, Zhi-Bin ; Valeru, Anil; Xu, Yin; Liu, Bin; et al, Synthesis, 2018, 50(9), 1815-1819

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Benzyltriethylammonium chloride , Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone ; 3 h, rt; rt → 0 °C
1.2 5 min, < 5 °C; 30 min, 0 °C
1.3 Reagents: Sodium bisulfite Solvents: Water

参考文献：

An efficient and practical method for olefin dihydroxylation

Luo, Zhi-bin; Zhao, Chen; Xie, Jimin; Lu, Hong-fei, Synthesis, 2016, 48(21), 3696-3700

合成路线：1 步

535-11-5

15186-48-8

_70%

反应条件：

1.1 Reagents: Triphenylphosphine Solvents: Water ; rt → 80 °C; 15 - 18 h, 70 - 80 °C
1.2 Solvents: Dichloromethane ; 0 - 5 °C; 0.5 h, 0 - 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; 5 °C → 25 °C; 1 - 3 h, 20 - 25 °C
1.4 Reagents: Potassium , Sodium chlorite Solvents: tert-Butanol , Water ; rt; 24 h, rt
1.5 Reagents: Water , Sodium sulfite

参考文献：

Method for preparing ethyl 2-C-methyl-4,5-O-(1-methylethylidene)-D-arabinate

, China, , ,

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Ethylene glycol , Sodium bicarbonate , Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone , Water ; 2 h, -10 °C; 1 h, -10 °C
1.2 Reagents: Sodium bisulfite Solvents: Water

参考文献：

Preparation of 2'-disubstituted nucleoside and nucleotide triphosphate derivatives and their use as anti-HCV and antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步

_66%

反应条件：

参考文献：

Preparation of 2'-cyano nucleoside and nucleotide triphosphate derivatives and their use as anti-HCV and antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步

_66%

反应条件：

参考文献：

Preparation of 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_62%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Acetone , Ethylene glycol ; -20 - -15 °C
1.2 Reagents: Sodium permanganate Solvents: Water ; 1.5 h, -20 - -15 °C
1.3 Reagents: Sodium bisulfite Solvents: Water ; 1 h, 0 - 5 °C

参考文献：

Preparation method of intermediate of sofosbuvir

, China, , ,

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Ethylene glycol , Sodium bicarbonate , Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone , Water ; 1 h, -15 - -10 °C; 1 h, -15 - -10 °C
1.2 Reagents: Sodium bisulfite Solvents: Water ; < 4 °C

参考文献：

Preparation of 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

, Canada, , ,

合成路线：1 步

_54%

反应条件：

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone ; 5 h, 0 - 5 °C

参考文献：

Bi- and monocyclic nucleoside analogs for treatment of hepatitis e

, World Intellectual Property Organization, , ,

合成路线：1 步

_54%

反应条件：

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone ; 5 h, 0 - 5 °C
1.2 Reagents: Sodium sulfite Solvents: Water

参考文献：

Preparation of substituted nucleosides, nucleotides and analogs thereof as antitumor and HCV antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步

_43%

反应条件：

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone ; 2 h, 0 - 5 °C
1.2 Reagents: Sodium sulfite Solvents: Water ; 2 h

参考文献：

prepn of substituted nucleosides, nucleotides and analogs thereof as antiviral agents

, United States, , ,

合成路线：1 步

_43%

反应条件：

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Acetone ; 0 - 5 °C; 2 h, 0 - 5 °C
1.2 Reagents: Sodium sulfite Solvents: Water ; 2 h, 0 - 5 °C

参考文献：

Preparation of substituted nucleosides, nucleotides and analogs thereof as antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Ethylene glycol , Sodium bicarbonate , Sodium permanganate Solvents: Ethyl acetate ; -10 - -5 °C; -5 °C → 0 °C; 0 - 10 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Process for preparation of 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribose-γ-lactone

, China, , ,

合成路线：1 步

参考文献：

Improved synthesis method of sofosbuvir drug for treatment of hepatitis C by using sodium permanganate oxidizer, tin tetrachloride catalyst and pentafluorophenol

, China, , ,

合成路线：1 步

参考文献：

2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

, United States, , ,

合成路线：1 步

参考文献：

Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidine and purine nucleoside analogs via condensation of the lactone to nucleosides as potential antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步