93670-18-9 (3-(4-溴苯氧基)丙酸,3-(4-bromophenoxy)propanoic acid)

反应条件：

1.1 Reagents: N-Bromosuccinimide , Sodium hydroxide Solvents: Water ; rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3

参考文献：

Preparation method of 6-bromo-4-hydro chromone

, China, , ,

合成路线：1 步

118449-57-3

_95%

反应条件：

1.1 Reagents: Hydrochloric acid ; 1 - 2 h, 80 - 90 °C

参考文献：

Acid activated montmorillonite K-10 mediated intramolecular acylation: simple and convenient synthesis of 4-chromanones

Begum, Ayisha F.; Balasubramanian, Kalpattu K.; Shanmugasundaram, Bhagavathy, Tetrahedron Letters, 2021, 82,

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 3 min, heated; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3

参考文献：

Synthesis of β-(aryloxy)propionic acids and chroman-4-ones under microwave irradiation

Li, Hong-ya; Liu, Hui-min; Wu, Guo-jiang; Li, Shu-na; Hao, Qing-hong; et al, Hebei Daxue Xuebao, 2008, 28(4), 399-402

合成路线：1 步

590-92-1

_78%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt; 30 min, rt; 90 min, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, rt

参考文献：

Preparation of anthracene compounds as organic electroluminescent device materials

, Korea, , ,

合成路线：1 步

590-92-1

_60%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt; rt → reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ; reflux; 2 h, reflux; reflux → 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 6 - 7

参考文献：

Preparation of spiro azole compounds as inhibitors of beta-secretase

, World Intellectual Property Organization, , ,

合成路线：1 步

7170-38-9

_45%

反应条件：

1.1 Reagents: N-Bromosuccinimide , Sodium hydroxide Solvents: Water ; rt; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, rt

参考文献：

Preparation of pyrrolo[2,3-b]pyridines or pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

118449-57-3

_42%

反应条件：

1.1 Reagents: Formic acid , Hydrochloric acid Solvents: Water ; 24 h, heated

参考文献：

Efficient Synthesis of Chromones with Alkenyl Functionalities by the Heck Reaction

Patonay, Tamas; Vasas, Attila; Kiss-Szikszai, Attila; Silva, Artur M. S.; Cavaleiro, Jose A. S., Australian Journal of Chemistry, 2010, 63(11), 1582-1593

合成路线：1 步

_24%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Potassium iodide Solvents: Water ; 30 min
1.2 Reagents: Potassium hydroxide Solvents: Water ; rt; 6 h, 110 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, cooled; pH 3 - 4

参考文献：

Chroman-like compound as antiarrhythmic agent and its preparation

, China, , ,

合成路线：1 步

590-92-1

_14%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 10 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized

参考文献：

Investigation on the Surface-Confined Self-Assembly Stabilized by Hydrogen Bonds of Urea and Amide Groups: Quantitative Analysis of Concentration Dependence of Surface Coverage

Nishitani, Nobuhiko; Hirose, Takashi; Matsuda, Kenji, Chemistry - An Asian Journal, 2015, 10(9), 1926-1931

合成路线：1 步

_10%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; overnight, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, rt

参考文献：

Preparation of 1H-indazole derivatives as HSD17B13 inhibitors and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt; rt → 75 °C; 12 h, 75 - 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Copper-Catalyzed Asymmetric Hydroboration of 2H-Chromenes Using a Chiral Diphosphine Ligand

Li, Xiufen; Wang, Chaoqiong; Song, Jianqiao; Yang, Zhihong; Zi, Guofu ; et al, Journal of Organic Chemistry, 2019, 84(13), 8638-8645

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; reflux

参考文献：

Hydrated ferric sulfate-catalyzed reactions of indole with aldehydes, ketones, cyclic ketones, and chromanones: Synthesis of bisindoles and trisindoles

Noland, Wayland E.; Kumar, Honnaiah Vijay; Flick, Grant C.; Aspros, Cole L.; Yoon, Jong Hyeon; et al, Tetrahedron, 2017, 73(27-28), 3913-3922

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt; 2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Synthesis, evaluation and in silico molecular modeling of pyrrolyl-1,3,4-thiadiazole inhibitors of InhA

Joshi, Shrinivas D.; More, Uttam A.; Koli, Deepshikha; Kulkarni, Manoj S.; Nadagouda, Mallikarjuna N.; et al, Bioorganic Chemistry, 2015, 59, 151-167

合成路线：1 步