937236-73-2 (ethyl 2-(2-chloropyridin-4-yl)acetate,ethyl 2-(2-chloro-4-pyridyl)acetate)

_93%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran , Hexane ; 2 h, -78 °C
1.2 overnight, -78 °C; -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Beta-lactamase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Triphenylphosphine Catalysts: Palladium diacetate Solvents: Ethanol ; rt

参考文献：

Preparation of [1,3]thiazolo[5,4-b]pyridine-2-amine derivatives as VEGF receptor 2 kinase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 2 h, -78 °C
1.2 Reagents: Hexamethylphosphoramide ; 1 h, -78 °C; rt
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Preparation of heterocyclic compounds as glucokinase activators

, World Intellectual Property Organization, , ,

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 2 h, -78 °C
1.2 3 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Prepartion of pyrimidines as ferroportin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 2 h, -78 °C
1.2 3 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water ; rt

参考文献：

Prepartion of cycloalka-fused pyrimidines as ferroportin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 3 h, -78 °C; 15 min, -78 °C
1.2 10 min, -78 °C; -78 °C → 0 °C; 20 min, 0 °C
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Preparation of pyrazolylurea compounds as hemopoietic cell kinase (p59-HCK) inhibitors for treatment of influenza infection

, World Intellectual Property Organization, , ,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 3 h, -78 °C; 15 min, -78 °C
1.2 10 min, -78 °C; -78 °C → 0 °C; 20 min, 0 °C
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Pyrazolylurea derivatives as antiviral agents and their preparation and use in the treatment of viral infection

, World Intellectual Property Organization, , ,

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 3 h, -78 °C; 15 min, -78 °C
1.2 10 min, -78 °C → 0 °C; 20 min, 0 °C
1.3 Reagents: Ammonium chloride Solvents: Water ; 0 °C

参考文献：

Preparation of pyrazolyl ureas as p38 MAP kinase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_38%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; -78 °C; 0.5 h, -78 °C → 0 °C; 0 °C → -78 °C
1.2 -78 °C; 0.5 h, -78 °C; -78 °C → rt

参考文献：

Quinolone derivatives, especially oxopyridopirimidines, as fibroblast growth factor inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_33%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; -78 °C; 2 h, -78 °C
1.2 -78 °C; 12 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water ; 0 °C

参考文献：

Preparation of 18F-labeled coumarin derivatives useful as in vivo imaging agent for MAO-B

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran , Hexane ; -78 °C; 1 h, -78 °C
1.2 overnight, -78 °C; -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water

参考文献：

Preparation of heteroaryl antagonists of prostaglandin D2 receptors

, World Intellectual Property Organization, , ,

合成路线：1 步