938-33-0 (8-甲氧基喹啉,8-Methoxyquinoline)

_100%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Tetrahydrofuran ; rt; overnight, rt

参考文献：

Preparation of 1,2,3,4-tetrahydroquinoline derivative useful in the treatment of diabetes

, World Intellectual Property Organization, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 48 h, reflux

参考文献：

A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts

Bringmann, Gerhard; Thomale, Katja; Bischof, Sebastian; Schneider, Christoph; Schultheis, Martina; et al, Antimicrobial Agents and Chemotherapy, 2013, 57(7), 3003-3011

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 3 h, reflux
1.2 6 h, rt

参考文献：

Synthesis, spectroscopy and computational studies of some biologically important hydroxyhaloquinolines and their novel derivatives

Malecki, Grzegorz; Nycz, Jacek E.; Ryrych, Ewa; Ponikiewski, Lukasz; Nowak, Maria; et al, Journal of Molecular Structure, 2010, 969(1-3), 130-138

合成路线：1 步

762-42-5

_95%

反应条件：

1.1 Reagents: 1-Methylimidazole ; 1 min, rt
1.2 20 s, rt; 7 min, 100 °C

参考文献：

N-methylimidazole-mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions

Djahaniani, Hoorieh; Aghadadashi-Abhari, Laila; Mohtat, Bita, Journal of the Serbian Chemical Society, 2015, 80(4), 459-464

合成路线：1 步

53899-17-5

_94%

反应条件：

1.1 Reagents: Potassium tert-butoxide , Oxygen Solvents: 2-Methyl-2-butanol ; 10 - 24 h, 120 °C

参考文献：

KOtBu/O2 Mediated Dehydrogenation of N-Heterocycles, Alcohols

Fu, Xuegang; Wang, Yue; Liu, Liu; Li, Caifeng; Huang, Lin; et al, ChemistrySelect, 2022, 7(30),

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; rt; overnight, rt

参考文献：

Development of highly selective dual mode chromogenic and fluorogenic chemosensor for Bi3+ ions

Saravana Kumar, S.; Selva Kumar, R.; Ashok Kumar, S. K., Journal of Molecular Structure, 2020, 1212,

合成路线：1 步

504-63-2

90-04-0

_91%

反应条件：

1.1 Catalysts: Bismuth cobalt carbonate oxide (Bi2Co(CO3)O2) ; 48 h, 150 °C

参考文献：

Sustainable synthesis of azobenzenes, quinolines and quinoxalines via oxidative dehydrogenative couplings catalysed by reusable transition metal oxide-Bi(iii) cooperative catalysts

Kocsis, Marianna; Baan, Kornelia; Otvos, Sandor B.; Kukovecz, Akos; Konya, Zoltan; et al, Catalysis Science & Technology, 2023, 13(10), 3069-3083

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; rt; 24 h, reflux

参考文献：

Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines

Hassan, Mirja Mahamudul Md; Hoque, Emdadul Md; Dey, Sayan; Guria, Saikat; Roy, Brindaban; et al, Synthesis, 2021, 53(18), 3333-3342

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 30 min, rt
1.2 rt; overnight, rt

参考文献：

Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors

Li, Kun; Li, Ying; Zhou, Di; Fan, Yinbo; Guo, Hongye; et al, Bioorganic & Medicinal Chemistry, 2016, 24(8), 1889-1897

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Acetonitrile ; 30 min, rt

参考文献：

Polymer supported synthesis of bioactive heterocyclic compounds

More, Uttam B.; Narkhede, Hemant P.; Raut, Changdeo N.; Mahulikar, Pramod P., Indian Journal of Heterocyclic Chemistry, 2009, 19(1), 43-46

合成路线：1 步

616-38-6

_88%

反应条件：

1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Dimethylformamide ; 10 min, 220 °C

参考文献：

A Continuous Base-Catalyzed Methylation of Phenols with Dimethyl Carbonate

Tilstam, Ulf, Organic Process Research & Development, 2012, 16(5), 1150-1153

合成路线：1 步

682351-22-0

_88%

反应条件：

1.1 Solvents: Ethanol ; reflux

参考文献：

Heteroannulation of 3-bis(methylthio)acrolein with aromatic amines - a convenient highly regioselective synthesis of 2-(methylthio)quinolines and their benzo/hetero fused analogs - a modified skraup quinoline synthesis

Panda, Kausik; Siddiqui, Iffat; Mahata, Pranab K.; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar, Synlett, 2004, (3), 449-452

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; cooled; 8 h, rt
1.2 Reagents: Ethanol ; rt

参考文献：

Tetradentate cyclometal platinum(II) and palladium(II) complex luminescent material containing quinoline structural unit and application thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; rt; 8 h, cooled
1.2 Reagents: Ethanol

参考文献：

Metal platinum(II) and palladium(II) complex containing quinoline structural unit and bridging structure, organic light-emitting device and display or lighting device containing the same

, China, , ,

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium hydride Catalysts: Sodium iodide Solvents: Dimethylformamide ; rt; overnight, rt
1.2 Reagents: Ethanol ; rt

参考文献：

5/6/6-Ring-fused tetradentate cyclometallated platinum(II) complex phosphorescent material based on quinoline unit structure and application thereof in electroluminescence devices

, China, , ,

合成路线：1 步

611-33-6

67-56-1

_86%

反应条件：

1.1 Reagents: Sodium tert-butoxide Catalysts: [3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]bis(1,1-dimethyl… , Palladium(1+), [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][[3,6-dimethoxy-2′,4′,6′-tr… Solvents: 1,4-Dioxane ; 20 h, 50 °C

参考文献：

Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst

Cheung, Chi Wai; Buchwald, Stephen L., Organic Letters, 2013, 15(15), 3998-4001

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dimethylformamide , Tetrahydrofuran ; 12 h, rt
1.2 Reagents: Water

参考文献：

Preparation of tetracyclic xanthene amino acid derivatives for treatment of viral diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_80%