938-87-4 ((2-methyl-1-phenylbutan-1-one)

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Trimethylamine oxide , Tricarbonyl[(1,3,3a,7a-η)-4,5,6,7-tetrahydro-1,3-bis(trimethylsilyl)-2H-inden-2-… Solvents: Methanol ; 24 h, 80 °C

参考文献：

Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach

Polidano, Kurt; Allen, Benjamin D. W.; Williams, Jonathan M. J.; Morrill, Louis C., ACS Catalysis, 2018, 8(7), 6440-6445

合成路线：1 步

80317-46-0

_99%

反应条件：

1.1 Catalysts: Potassium tert-butoxide , Chloro[2-(diphenylphosphino-κP)ethanamine-κN][(1,2,3,4,5-η)-1,2,3,4,5-pentamethy… Solvents: Toluene ; 1 h, 30 °C

参考文献：

CpRu(PN) Complex-Catalyzed Isomerization of Allylic Alcohols and Its Application to the Asymmetric Synthesis of Muscone

Ito, Masato; Kitahara, Sachiko; Ikariya, Takao, Journal of the American Chemical Society, 2005, 127(17), 6172-6173

合成路线：1 步

1519-23-9

98-80-6

_98%

反应条件：

1.1 Reagents: Water Catalysts: Tris(4-methoxyphenyl)phosphine , Palladium diacetate Solvents: Tetrahydrofuran

参考文献：

Palladium-catalyzed synthesis of aryl ketones from boronic acids and carboxylic acids or anhydrides

Goossen, Lukas J.; Ghosh, K., Angewandte Chemie, 2001, 40(18), 3458-3460

合成路线：1 步

74-88-4

_97%

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium Solvents: Tetrahydrofuran , Hexane

参考文献：

The transition metal catalysed isomerisation of allylic alkoxides

Gazzard, Lewis John, 1995, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Lithium tert-butoxide Catalysts: Di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-… , Bis[2-(diphenylphosphino)phenyl] ether ; rt → 110 °C; 24 h, 110 °C

参考文献：

A Convenient Ruthenium-Catalyzed α-Methylation of Carbonyl Compounds using Methanol

Dang, Tuan Thanh; Seayad, Abdul Majeed, Advanced Synthesis & Catalysis, 2016, 358(21), 3373-3380

合成路线：1 步

78-86-4

65-85-0

_96%

反应条件：

1.1 Catalysts: Naphthalene , Lithium Solvents: Tetrahydrofuran

参考文献：

Direct Easy Synthesis of Ketones from Carboxylic Acids and Chlorinated Compounds

Alonso, Francisco; Lorenzo, Emilio; Yus, Miguel, Journal of Organic Chemistry, 1996, 61(17), 6058-6059

合成路线：1 步

78-76-2

98-88-4

_95%

反应条件：

1.1 Reagents: Zinc Solvents: Tetrahydrofuran
1.2 Catalysts: Cuprous cyanide , Lithium bromide Solvents: Tetrahydrofuran

参考文献：

Direct Formation of Secondary and Tertiary Alkylzinc Bromides and Subsequent Cu(I)-Mediated Couplings

Rieke, Reuben D.; Hanson, Mark V.; Brown, Jeffrey D.; Niu, Q. Jason, Journal of Organic Chemistry, 1996, 61(8), 2726-30

合成路线：1 步

78-76-2

98-88-4

_95%

反应条件：

1.1 Reagents: Zinc Solvents: Tetrahydrofuran
1.2 Reagents: Cuprous cyanide , Lithium bromide Solvents: Tetrahydrofuran

参考文献：

Direct formation of secondary and tertiary alkylzinc bromides

Hanson, Mark V.; Brown, Jeff D.; Rieke, Reuben D.; Niu, Q. Jason, Tetrahedron Letters, 1994, 35(39), 7205-8

合成路线：1 步

107454-42-2

98-88-4

_95%

反应条件：

1.1 Solvents: Diethyl ether

参考文献：

Organocuprates containing dimethyl sulfoxide anion as a nontransferable ligand

Johnson, Carl R.; Dhanoa, Daljit S., Journal of Organic Chemistry, 1987, 52(10), 1885-8

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Triphenylphosphine , Cobalt bis(tetrafluoroborate) hexahydrate Solvents: Methanol ; 24 h, 100 °C

参考文献：

Methylation of C(sp3)-H/C(sp2)-H Bonds with Methanol Catalyzed by Cobalt System

Liu, Zhenghui; Yang, Zhenzhen; Yu, Xiaoxiao; Zhang, Hongye; Yu, Bo; et al, Organic Letters, 2017, 19(19), 5228-5231

合成路线：1 步

57526-28-0

71-43-2

_93%

反应条件：

1.1 Catalysts: Aluminum chloride Solvents: Benzene ; 90 min, rt; rt → reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C

参考文献：

Synthesis of 2-methyl-2-hydroxy-1-phenyl-1-butanone

Hu, Ying-xi; Zhao, Shi-wei; Fan, Li-chang, Huaxue Shijie, 2008, 49(5), 290-292

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: Ruthenium(1+), bis(acetonitrile)chloro[6-(1,10-phenanthrolin-2-yl-κN1,κN10)-2-py… Solvents: Methanol ; 24 h, 85 °C

参考文献：

Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction

Chakrabarti, Kaushik; Maji, Milan; Panja, Dibyajyoti; Paul, Bhaskar; Shee, Sujan; et al, Organic Letters, 2017, 19(18), 4750-4753

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Iridium, di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopen… ; 15 h, 120 °C

参考文献：

Iridium-catalyzed selective α-methylation of ketones with methanol

Ogawa, Shinji; Obora, Yasushi, Chemical Communications (Cambridge, 2014, 50(19), 2491-2493

合成路线：1 步

4393-06-0

64-17-5

_88%

反应条件：

1.1 Reagents: Lithium tert-butoxide Catalysts: Palladium diacetate , Tris(2-furyl)phosphine ; 24 h, 130 °C

参考文献：

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

Biswal, Priyabrata; Samser, Shaikh; Meher, Sushanta Kumar; Chandrasekhar, Vadapalli; Venkatasubbaiah, Krishnan, Advanced Synthesis & Catalysis, 2022, 364(2), 413-419

合成路线：1 步

_86%

反应条件：

1.1 Catalysts: Lithium tert-butoxide , Tricyclohexylphosphine , 2375086-73-8 Solvents: Methanol ; 120 h, 48 °C

参考文献：

Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol

Mamidala, Ramesh ; Biswal, Priyabrata; Subramani, M. Siva; Samser, Shaikh ; Venkatasubbaiah, Krishnan, Journal of Organic Chemistry, 2019, 84(16), 10472-10480

合成路线：1 步

74-88-4

_86%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran , Hexane ; -78 °C → 0 °C; 3 h, 0 °C
1.2 0 °C → rt; 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Chiral Bronsted Acid from a Cationic Gold(I) Complex: Catalytic Enantioselective Protonation of Silyl Enol Ethers of Ketones

Cheon, Cheol Hong; Kanno, Osamu; Toste, F. Dean, Journal of the American Chemical Society, 2011, 133(34), 13248-13251

合成路线：1 步

_81%