939-48-0 (异丙基苯甲酸酯,Isopropyl Benzoate)

_100%

反应条件：

1.1 300 s, 120 °C

参考文献：

Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow

Van Waes, Frederik E. A.; Drabowicz, J.; Cukalovic, A.; Stevens, Christian V., Green Chemistry, 2012, 14(10), 2776-2779

合成路线：1 步

93-97-0

75-65-0

_100%

反应条件：

1.1 Catalysts: Oxobis(1,1,1-trifluoromethanesulfonato-κO)zirconium Solvents: Acetonitrile ; rt → 50 °C; 10 min, 50 °C

参考文献：

Zirconyl triflate: a new, highly efficient and reusable catalyst for acetylation and benzoylation of alcohols, phenols, amines and thiols with acetic and benzoic anhydrides

Moghadam, M.; Tangestaninejad, S.; Mirkhani, V.; Mohammadpoor-Baltork, I.; Babaghanbari, M.; et al, Journal of the Iranian Chemical Society, 2009, 6(3), 523-532

合成路线：1 步

54769-36-7

_100%

反应条件：

1.1 Solvents: Isopropanol

参考文献：

Simple and mild esterification method for carboxylic acids using sulfonate-type coupling reagents

Itoh, Masumi; Hagiwara, Daijiro; Notani, Jiyoji, Synthesis, 1975, (7), 456-8

合成路线：1 步

93-89-0

_99%

反应条件：

1.1 Catalysts: Potassium tert-butoxide , Bis(acetonitrile)(η5-2,4-cyclopentadien-1-yl)[tris(1-methylethyl)phosphine]ruthe… ; 2 h, 70 °C

参考文献：

Transfer Hydrogenation of Ketones, Nitriles, and Esters Catalyzed by a Half-Sandwich Complex of Ruthenium

Lee, Sun-Hwa; Nikonov, Georgii I., ChemCatChem, 2015, 7(1), 107-113

合成路线：1 步

75-26-3

65-85-0

_99%

反应条件：

1.1 Reagents: Triethylamine Solvents: 1-Butyl-3-methylimidazolium hexafluorophosphate ; 1 h, 60 °C

参考文献：

Ionic liquids as solvent for efficient esterification of carboxylic acids with alkyl halides

Gok, Yetkin; Alici, Bulent; Cetinkaya, Engin; Ozdemir, Ismail; Ozeroglu, Ozlem, Turkish Journal of Chemistry, 2010, 34(2), 187-191

合成路线：1 步

683-60-3

100-51-6

_99%

反应条件：

1.1 Catalysts: Stereoisomer of bis[6-[[bis(1,1-dimethylethyl)phosphino-κP]methyl]-N,N-diethyl-2… Solvents: 1,4-Dioxane ; rt; rt → 100 °C; 24 h, 100 °C; 100 °C → rt

参考文献：

Electron-rich, bulky PNN-type ruthenium complexes: Synthesis, characterization and catalysis of alcohol dehydrogenation

Zhang, Jing; Gandelman, Mark; Shimon, Linda J. W.; Milstein, David, Dalton Transactions, 2007, (1), 107-113

合成路线：1 步

55-21-0

_98%

反应条件：

1.1 Catalysts: Boron trifluoride etherate ; 80 °C

参考文献：

Green preparation of benzoate compounds catalyzed by boron salt

, China, , ,

合成路线：1 步

65-85-0

_98%

反应条件：

1.1 Catalysts: Methanesulfonic acid (alumina-supported) ; 8 min, 80 °C

参考文献：

Efficient Microwave-Assisted Esterification Reaction Employing Methanesulfonic Acid Supported on Alumina as Catalyst

Fabian, Lucas; Gomez, Matias; Kuran, Juan A. Caturelli; Moltrasio, Graciela; Moglioni, Albertina, Synthetic Communications, 2014, 44(16), 2386-2392

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Allyltributyltin Catalysts: Trifluoromethanesulfonic acid Solvents: Dichloromethane
1.2 -

参考文献：

A new method for the synthesis of stannyl ethers by acid-catalyzed reaction of alcohols with allyltributylstannane

Yamago, Shigeru; Yamada, Takeshi; Nishimura, Ryuji; Ito, Hiroki; Mino, Yosuke; et al, Chemistry Letters, 2002, (2), 152-153

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: Palladium (phosphorus-doped porous organic polymer supported) Solvents: Isopropanol ; 5 h, 1 atm, 80 °C

参考文献：

Carbonylative Suzuki coupling and alkoxycarbonylation of aryl halides using palladium supported on phosphorus-doped porous organic polymer as an active and robust catalyst

Wan, Yali; Song, Fangxiang; Ye, Tao; Li, Guangxing; Liu, Dingfu ; et al, Applied Organometallic Chemistry, 2019, 33(2),

合成路线：1 步

35118-50-4

_97%

反应条件：

1.1 Catalysts: 1,10-Phenanthroline , Copper oxide (Cu2O) Solvents: Quinoline , N-Methyl-2-pyrrolidone ; 12 h, 170 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Copper-catalyzed protodecarboxylation of aromatic carboxylic acids

Goossen, Lukas J.; Thiel, Werner R.; Rodriguez, Nuria; Linder, Christophe; Melzer, Bettina, Advanced Synthesis & Catalysis, 2007, 349, 2241-2246

合成路线：1 步

反应条件：

1.1 Catalysts: Zinc acetate Solvents: Isopropanol ; 6 h, 75 °C

参考文献：

Zn-Catalyzed tert-Butyl Nicotinate-Directed Amide Cleavage as a Biomimic of Metallo-Exopeptidase Activity

Wybon, Clarence C. D. ; Mensch, Carl; Hollanders, Charlie; Gadais, Charlene; Herrebout, Wouter A. ; et al, ACS Catalysis, 2018, 8(1), 203-218

合成路线：1 步

反应条件：

1.1 Catalysts: Zinc acetate Solvents: Isopropanol ; 6 h, 75 °C

参考文献：

Process for the catalytic directed cleavage of amide-containing compounds

, World Intellectual Property Organization, , ,

合成路线：1 步

75-26-3

65-85-0

_96%

反应条件：

1.1 Catalysts: Urea , Choline chloride ; 1 h, heated; 20 - 40 °C
1.2 Reagents: Triethylamine ; 1 h, 60 °C

参考文献：

Process for the preparation of carboxylate via esterification of acids using eutectic solution of choline chloride and urea as solvent and catalyst

, China, , ,

合成路线：1 步

87668-28-8

683-60-3

_96%

参考文献：

Reactions of 2,2-dihalo-1,3-diphenylpropanones with isopropoxide and methoxide anions

Cabaleiro, Mercedes C.; Garay, Raul O., Journal of Chemical Research, 1983, (6), 154-5

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Diisopropylethylamine Catalysts: Palladium, bis(1-butyl-1H-imidazole-N3)dichloro-, (SP-4-1)- Solvents: Water ; 2 h, 1 atm, 60 °C

参考文献：

Palladium nanoparticles generated in-situ used as catalysts in carbonylative cross-coupling in aqueous medium

Wojcik, P.; Mart, M.; Ulukanli, S.; Trzeciak, A. M., RSC Advances, 2016, 6(43), 36491-36499

合成路线：1 步

93-58-3

_95%

反应条件：

1.1 Reagents: Acetone , Sodium borohydride Solvents: Isopropanol ; 30 min, rt
1.2 24 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Sodium Borohydride-Mediated Transesterification

Sereda, Grigoriy; Pothula, Swetha; Dreessen, James, Synthetic Communications, 2010, 40(9), 1312-1321

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 0 °C; 1 - 4 h, 0 °C → rt

参考文献：

Direct Amidation of Esters by Ball Milling

Nicholson, William I.; Barreteau, Fabien; Leitch, Jamie A.; Payne, Riley; Priestley, Ian; et al, Angewandte Chemie, 2021, 60(40), 21868-21874

合成路线：1 步

_95%