93957-50-7 ((E)-3-[3'-(4''-氟苯基)-1'-异丙基-1H-吲哚-2''-基]-2-丙烯醛,(E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde)

反应条件：

1.1 Solvents: Chloroform-d ; 2 d, rt

参考文献：

Bronsted Acids Enable Three Molecular Rearrangements of One 3-Alkylidene-2H-1,2-oxazine Molecule into Distinct Heterocyles

Mokar, Bhanudas Dattatray; Liu, Jinxian; Liu, Rai-Shung, Organic Letters, 2018, 20(4), 1038-1041

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; 45 min, -5 °C; 10 min, 5 - 7 °C
1.2 Solvents: Acetonitrile ; 5 °C → reflux; 3 h, reflux; reflux → rt
1.3 Solvents: Water ; rt

参考文献：

Facile and Highly Enantioselective Synthesis of (+)- and (-)-Fluvastatin and Their Analogues

Zacharia, James T.; Tanaka, Takanori; Hayashi, Masahiko, Journal of Organic Chemistry, 2010, 75(22), 7514-7518

合成路线：1 步

34900-01-1

_83%

反应条件：

1.1 Reagents: Phosphorus oxychloride

参考文献：

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles

Jones, Gurnos; Stanforth, Stephen P., Organic Reactions (Hoboken, 1997, 49,

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; -5 °C; 10 min, 5 - 7 °C
1.2 3 h, reflux; reflux → rt
1.3 Reagents: Water ; 1.5 h

参考文献：

Synthesis of (3R,5S,6E)-rel-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt (fluvastatin sodium)

Cai, Zhengyan; Ning, Qi; Zhou, Weicheng, Zhongguo Yiyao Gongye Zazhi, 2007, 38(2), 73-75

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; 3 h, 80 °C

参考文献：

A catalytic approach to the synthesis of (+)-fluvastatin analogue

Kim, Aejin; Kim, In Su, Bulletin of the Korean Chemical Society, 2011, 32(10), 3748-3751

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; 3 h, 80 °C

参考文献：

Method for preparation of (+)-fluvastatin

, Korea, , ,

合成路线：1 步

34900-01-1

_75%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; 45 min, -5 °C; 10 min, 5 - 7 °C
1.2 10 min, 5 - 7 °C; 3 h, 7 °C → 83 °C; 83 °C → 22 °C
1.3 Reagents: Water ; 15 min, 22 °C; 0.5 h, 35 - 50 °C; 1.5 h, 50 °C → 55 °C; 55 °C → 22 °C; 15 min, 22 °C

参考文献：

Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus

Kalalbandi, Veerendra Kumar A.; Seetharamappa, J.; Katrahalli, Umesha, RSC Advances, 2015, 5(48), 38748-38759

合成路线：1 步

34900-01-1

_75%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile
1.2 Solvents: Acetonitrile

参考文献：

Vinylformylation utilizing propeniminium salts

Lee, George T.; Amedio, John C. Jr.; Underwood, Russell; Prasad, Kapa; Repic, Oljan, Journal of Organic Chemistry, 1992, 57(11), 3250-2

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; -5 °C; 45 min, 5 - 7 °C
1.2 10 min, 5 - 7 °C; 3 h, 83 °C; 83 °C → 22 °C
1.3 Reagents: Sodium hydroxide Solvents: Toluene , Water ; 20 min, 25 - 30 °C; 30 °C → 22 °C
1.4 Reagents: Hydrochloric acid , Sodium chloride Solvents: Water ; 30 min, 22 °C

参考文献：

Synthesis of (3R,5S,6E)-rel-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-Heptenoic acid sodium salt (1:1) (fluvastatin sodium)

Jin, Hong-ri; Chen, Xiao-fang; Yan, Qi-dong; Yang, Mei-ling, Hecheng Huaxue, 2008, 16(3), 358-361

合成路线：1 步

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile

参考文献：

Synthesis, characterization, crystal studies of (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) acrylaldehyde

Kalalbandi, Veerendra Kumar A.; Seetharamappa, J., Crystal Structure Theory and Applications, 2013, 2(4), 150-156

合成路线：1 步

68-12-2

1118757-66-6

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ; 0 - 3 °C; 3 °C → rt; > 1 min, rt
1.2 Solvents: Dimethylformamide ; rt; 8 h, rt

参考文献：

Process for preparing an indole compound

, India, , ,

合成路线：1 步

参考文献：

Synthesis of (E)-3-[3-(4-fluorophenyl)-1-methylethyl)-1H- indol-2-yl]-2-propenal

Chen, Weiping; Liao, Yongwei; Yang, Genjin; Zhang, Wannian, Zhongguo Yaowu Huaxue Zazhi, 1998, 8(1), 50-53

合成路线：1 步

参考文献：

Preparation of N,N-disubstituted (E)-3-amino-2-propenals as mevalonate analog intermediates

, United States, , ,

合成路线：1 步

参考文献：

Analogs of mevalolactone and derivatives thereof and their use as pharmaceuticals

, World Intellectual Property Organization, , ,

合成路线：1 步

145797-78-0