939968-08-8 (2,6-DIFLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE,2,6-difluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline)

_100%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; overnight, 90 °C

参考文献：

Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme I (IRE-I alpha) for the treatment of cancer diseases and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; 3 h, 110 °C

参考文献：

Cdk4/6 inhibitor, preparation method and application thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 90 min, 80 °C

参考文献：

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

Chapman, Timothy M.; Osborne, Simon A.; Wallace, Claire; Birchall, Kristian; Bouloc, Nathalie; et al, Journal of Medicinal Chemistry, 2014, 57(8), 3570-3587

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 90 min, 80 °C

参考文献：

Preparation of imidazopyridazine derivatives for use as CDPK1 inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; overnight, rt → 90 °C

参考文献：

Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto

, World Intellectual Property Organization, , ,

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ; 12 h, 100 °C

参考文献：

Preparation of pyrimidine compounds, compositions, and medicinal applications thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 16 h, 80 °C

参考文献：

Preparation of 4-oxoquinolizines as antimicrobials

, World Intellectual Property Organization, , ,

合成路线：1 步

_73%

反应条件：

1.1 Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 16 h, 80 °C

参考文献：

Preparation of 2-pyridone antimicrobial compositions

, World Intellectual Property Organization, , ,

合成路线：1 步

141743-49-9

_69%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: 1,1-Bis(diphenylphosphino)ferrocene , Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ; 4 h, 80 °C

参考文献：

Preparation of biaryl compounds as GPR120 agonists

, World Intellectual Property Organization, , ,

合成路线：1 步

_62%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: Dimethyl sulfoxide ; 90 min, 80 °C; 80 °C → rt

参考文献：

Preparation of substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

, World Intellectual Property Organization, , ,

合成路线：1 步

_59%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 1.5 h, 80 °C

参考文献：

Preparation of heteroaryl compounds for treating Huntington's disease

, World Intellectual Property Organization, , ,

合成路线：1 步

_49%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ; 1 h, 80 °C

参考文献：

Azaindzoles as TYK2 inhibitors and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

141743-49-9

_43%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethylformamide ; 12 h, 90 °C

参考文献：

Compound having AXL inhibitory activity, preparation method and use

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; 2 h, 90 °C

参考文献：

Preparation of deuterated biphenylcarbamoylcyclopentene carboxylic acid derivatives and analogs for use as DHODH inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; 4 h, 100 °C

参考文献：

Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases

, United States, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; 4 h, 100 °C

参考文献：

Treatment of cancers having k-ras mutations using PI3 kinase and HDAC inhibitors and preparation of bifunctional thienopyrimidine compounds that inhibit both enzymes

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

Carboxamide derivatives as DHODH inhibitors and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步