940-61-4 (反-对甲基肉桂酸,3-(4-methylphenyl)prop-2-enoic acid)

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Palladium (complexes with [(aminoethyl)amino]cellulose) Solvents: Water ; 6 h, 80 °C

参考文献：

Preparation of palladium complex supported by ethylenediamine cellulose and its catalytic behavior for heck reaction

Xu, Ying; Zhao, Qinglan; Zhang, Lei; Jin, Jinghua; Cui, Yuanchen, Huaxue Yanjiu, 2008, 19(4), 73-77

合成路线：1 步

1031434-37-3

_100%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , 2-(Dimethylamino)ethanethiol hydrochloride Solvents: Acetonitrile ; 15 min, rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether , Water ; rt

参考文献：

(1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids

Nishimura, Takuya; Yamada, Kouhei; Takebe, Tohru; Yokoshima, Satoshi; Fukuyama, Tohru, Organic Letters, 2008, 10(12), 2601-2604

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Ethylenediamine , Palladium , Polyacrylonitrile ; 20 min, 120 °C

参考文献：

Functional fiber with bis (N-heterocyclic carbene) structure prevents Pd(0) nanoparticle agglomeration for an efficient and recyclable Heck reaction

Zhang, Haonan; Liang, Wenlong ; Xiao, Jian; Zhao, Jinhao, Chemical Engineering Journal (Amsterdam, 2023, 455,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Palladium oxide (PdO) Solvents: Water ; 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Linear polystyrene-stabilized PdO nanoparticle-catalyzed Mizoroki-Heck reactions in water

Ohtaka, Atsushi; Yamaguchi, Tomohiro; Teratani, Takuto; Shimomura, Osamu; Nomura, Ryoki, Molecules, 2011, 16, 9067-9076

合成路线：1 步

106-38-7

_99%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Water ; 10 min, rt
1.2 Catalysts: (SP-4-3)-Dibromo[rel-1,3-dihydro-1-methyl-3-[[(1R,2S)-1-(phenylmethyl)-2-pyrroli… ; 24 h, 120 °C; 120 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1, rt

参考文献：

N-Heterocyclic carbene-Pd(II) complex derived from proline for the Mizoroki-Heck reaction in water

Tang, Yi-Qiang; Chu, Chun-Yan; Zhu, Lei; Qian, Bin; Shao, Li-Xiong, Tetrahedron, 2011, 67(49), 9479-9483

合成路线：1 步

76557-94-3

630-08-0

_99%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: Water , 1-Butyl-3-methylimidazolium hexafluorophosphate ; 10 h, 20 bar, 100 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Stereoselective Hydroxycarbonylation of Vinyl Bromides to α,β-Unsaturated Carboxylic Acids in the Ionic Liquid [BMIM]PF6

Zhao, Xiaodan; Alper, Howard; Yu, Zhengkun, Journal of Organic Chemistry, 2006, 71(10), 3988-3990

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 12 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1, 0 °C

参考文献：

Copper-Catalyzed Aerobic Aminooxygenation of Cinnamyl N-Alkoxycarbamates via Substrate-Promoted Catalyst Activation

McNichol, Caitlyn P. ; DeCicco, Ethan M. ; Canfield, Amanda M. ; Carstairs, Daniel P.; Paradine, Shauna M., ACS Catalysis, 2023, 13(10), 6568-6573

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 3 h, rt

参考文献：

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

Tardugno, Roberta; Giancotti, Gilda; De Burghgraeve, Tine; Delang, Leen ; Neyts, Johan; et al, Bioorganic & Medicinal Chemistry, 2018, 26(4), 869-874

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 85 °C; 6 h, 85 °C; 85 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized, cooled

参考文献：

Synthesis and bioactivities of novel piperazine-containing 1,5-Diphenyl-2-penten-1-one analogues from natural product lead

Xu, Gaofei; Yang, Xinling; Jiang, Biaobiao; Lei, Peng; Liu, Xili; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(7), 1849-1853

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 85 °C; 6 h, 85 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 85 °C → rt; neutralized, cooled

参考文献：

Synthesis and fungicidal activity study of novel daphneolone analogs with 2,6-dimethylmorpholine

Xu, Gao-Fei; Yang, Xin-Ling; Lei, Peng; Liu, Xi-li; Zhang, Xue-Bo; et al, Chinese Chemical Letters, 2016, 27(4), 555-558

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Lithium chloride ; 6 min

参考文献：

Microwave-assisted solvent-free synthesis of trans-cinnamic acids using lithium chloride as catalyst

Mogilaiah, K.; Reddy, G. Randheer, Synthetic Communications, 2004, 34(2), 205-210

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Ammonium acetate
1.2 Reagents: Water

参考文献：

Non solvent reaction: ammonium acetate catalyzed highly convenient preparation of trans-cinnamic acids

Kumar, H. M. Sampath; Subbareddy, B. V.; Anjaneyulu, S.; Yadav, J. S., Synthetic Communications, 1998, 28(20), 3811-3815

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; overnight, 115 °C; 115 °C → rt
1.2 Reagents: Water ; cooled
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3 - 4

参考文献：

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

Luo, Yong; Zhu, Yongxia; Ran, Kai; Liu, Zhihao; Wang, Ningyu; et al, MedChemComm, 2015, 6(6), 1036-1042

合成路线：1 步

106-38-7

_97%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide , Palladium Solvents: Water ; 5 h, 90 °C; 10 min, 90 °C → 20 °C

参考文献：

Application of 'boomerang' linear polystyrene-stabilized pd nanoparticles to a series of C-C coupling reactions in water

Ohtaka, Atsushi; Okagaki, Toshiyuki; Hamasaka, Go; Uozumi, Yasuhiro; Shinagawa, Tsutomu; et al, Catalysts, 2015, 5(1), 106-118

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Palladium Solvents: Dimethylformamide ; 7 h, 90 °C; 90 °C → rt
1.2 Reagents: Sodium carbonate Solvents: Water ; 20 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

Preparation of Pd nanoparticles deposited on a polyaniline/multiwall carbon nanotubes nanocomposite and their application in the Heck reaction

Nie, Guangrui; Zhang, Lei; Cui, Yuanchen, Reaction Kinetics, 2013, 108(1), 193-204

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Bismuth trichloride ; 3.5 min, heated

参考文献：

Bismuth(III) chloride-mediated, efficient, solvent-free, MWI-enhanced Doebner condensation for the synthesis of (E)-cinnamic acids

Kumar, Dhruva; Sandhu, Jagir S., Synthetic Communications, 2010, 40(13), 1915-1919

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Diethylenetriamine , Tetrabutylammonium chloride , Palladium Solvents: Dimethylformamide ; 12 h, 120 °C
1.2 Reagents: Sodium carbonate Solvents: Water ; 10 min, cooled

参考文献：

Synthesis of lignin-amine supported palladium catalysts for Heck reaction

Wu, Yufeng; Zhang, Lei; Cui, Yuanchen; Liu, Jiangsheng; Yang, Shuai, Shiyou Huagong, 2009, 38(7), 733-738

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Palladium (silica-supported complex with poly[(3-mercaptopropyl)siloxane]) Solvents: p-Xylene

参考文献：

Silica-supported poly[(γ-mercaptopropyl)siloxane] palladium(0) complex. A highly active and stereoselective catalyst of arylation of styrene and acrylic acid

Cai, Ming Zhong; Song, Cai Sheng; Huang, Xian, Synthesis, 1997, (5), 521-523

合成路线：1 步

56578-35-9

_95%

反应条件：

1.1 Reagents: Sodium carbonate , Oxygen Catalysts: Molybdate(4-), cupratehexa-μ3-hydroxyhexa-μ-oxododecaoxohexa-, ammonium (1:4) Solvents: Water ; 12 h, 50 °C

参考文献：

An Efficient Aerobic Oxidation Protocol of Aldehydes to Carboxylic Acids in Water Catalyzed by an Inorganic-Ligand-Supported Copper Catalyst

Yu, Han; Ru, Shi; Zhai, Yongyan; Dai, Guoyong; Han, Sheng; et al, ChemCatChem, 2018, 10(6), 1253-1257

合成路线：1 步

_95%