94142-97-9 (1,1-二氯-2,2-双(4-氯苯基)乙烯,2-(1-Hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione)

_90%

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 4 h, rt

参考文献：

Total and semisyntheses of polymyxin analogs with 2-Thr or 10-Thr modifications to decipher the structure-activity relationship and improve the antibacterial activity

Li, Jian; Guan, Dongliang; Chen, Feifei ; Shi, Weiwei; Lan, Lefu ; et al, Journal of Medicinal Chemistry, 2021, 64(9), 5746-5765

合成路线：1 步

108-24-7

_89%

反应条件：

1.1 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; overnight, rt

参考文献：

Synthesis and Activity of a New Series of Antileishmanial Agents

Kanwar, Ankush; Eduful, Benjamin J.; Barbeto, Linda; Carletti Bonomo, Piero; Lemus, Andrea; et al, ACS Medicinal Chemistry Letters, 2017, 8(8), 797-801

合成路线：1 步

108-24-7

_89%

反应条件：

1.1 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; overnight, rt

参考文献：

Preparation of heterocycles and their antimicrobial compositions, methods of use, and methods of treatment of infections

, World Intellectual Property Organization, , ,

合成路线：1 步

25952-53-8

_83%

反应条件：

1.1 Reagents: Acetic acid Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; overnight, rt

参考文献：

Optical imaging by confocal fluorescence endomicroscopy using fluorescent dyes conjugated with dendrimers or using quenched dyes

, World Intellectual Property Organization, , ,

合成路线：1 步

_76%

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)phenol Solvents: Dimethylformamide ; rt; overnight, rt

参考文献：

Single-molecule study of the synergistic effects of positive charges and Dopa for wet adhesion

Li, Yiran; Wang, Tiankuo; Xia, Lei; Wang, Lei; Qin, Meng; et al, Journal of Materials Chemistry B: Materials for Biology and Medicine, 2017, 5(23), 4416-4420

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide , 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; 36 h, rt

参考文献：

High Throughput Physical Organic Chemistry: Analytical Constructs for Monomer Reactivity Profiling

Portal, Christophe; Launay, Delphine; Merritt, Andrew; Bradley, Mark, Journal of Combinatorial Chemistry, 2005, 7(4), 554-560

合成路线：1 步

75-36-5

_64%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; 0 °C → rt; 3 h, rt
1.2 Reagents: Aluminum chloride Solvents: Dichloromethane ; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

Umezawa, Naoki; Horai, Yuhei; Imamura, Yuki; Kawakubo, Makoto; Nakahira, Mariko; et al, ChemBioChem, 2015, 16(12), 1811-1819

合成路线：1 步

_64%

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 3 h, rt
1.2 Reagents: Triethylamine , Potassium cyanide Solvents: Acetonitrile ; overnight, 40 °C

参考文献：

Orthogonal Regioselective Synthesis of N-Alkyl-3-substituted Tetrahydroindazolones

Kim, Jonghoon; Song, Heebum; Park, Seung Bum, European Journal of Organic Chemistry, 2010, (20), 3815-3822

合成路线：1 步

108-24-7

_58%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 10 min, rt
1.2 48 h, rt

参考文献：

N-1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) lipoamino acids

Ross, Benjamin P.; Falconer, Robert A.; Toth, Istvan, Molbank, 2008, (2),

合成路线：1 步

_56%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; 60 h, rt

参考文献：

Palladium-mediated bioorthogonal conjugation of dual-functionalized nanoparticles and their cellular delivery

Thielbeer, Frank; Chankeshwara, Sunay V.; Johansson, Emma M. V.; Norouzi, Neil; Bradley, Mark, Chemical Science, 2013, 4(1), 425-431

合成路线：1 步

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide , 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; 36 h, rt → 30 °C

参考文献：

Preparation method of (2S)-4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butanoic acid

, China, , ,

合成路线：1 步

3471-13-4

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; overnight, rt

参考文献：

Introduction of Functional Groups into Peptides via N-Alkylation

Demmer, O.; Dijkgraaf, I.; Schottelius, M.; Wester, H.-J.; Kessler, H., Organic Letters, 2008, 10(10), 2015-2018

合成路线：1 步