942271-60-5 (4-fluoro-2-nitro-benzoic acid tert-butyl ester,Tert-butyl 4-fluoro-2-nitrobenzoate)

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; overnight, rt

参考文献：

Indole derivatives as TrkA receptor inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 20 h, rt

参考文献：

Preparation of bi-functional small mol. compounds as tropomyosin receptor kinase (TRK) degradation compounds and methods of use

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: 1-Butanol , Dichloromethane ; 20 h, rt

参考文献：

Preparation of substituted indazole derivatives active as kinase inhibitors for treating cancer, cell proliferative disorders, and other diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 20 h, rt

参考文献：

Indazole derivatives as kinase inhibitors for the treatment of cancer and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 20 h, rt

参考文献：

Preparation of pyrrolo[3,4-c]pyrazole derivatives as IGF-1R inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 20 h, rt

参考文献：

Substituted pyrazolo[4,3-c]pyridine derivatives as tyrosine kinase inhibitors, particularly IGF-1R inhibitors, their preparation, pharmaceutical compositions, and use in therapy

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

_100%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 20 h, rt

参考文献：

Substituted pyrrolopyrazole derivatives as tyrosine kinase inhibitors, their preparation, pharmaceutical compositions, and use in therapy

, World Intellectual Property Organization, , ,

合成路线：1 步

_86%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 30 min, rt
1.2 Solvents: tert-Butanol ; 24 h, rt

参考文献：

Preparation of heterocyclic derivatives modulating activity of certain protein kinases

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

_82%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine , Di-tert-butyl dicarbonate Solvents: Dichloromethane , tert-Butanol ; overnight, rt

参考文献：

Preparation of hetero-bifunctional compounds as protein degraders

, World Intellectual Property Organization, , ,

合成路线：1 步

_82%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; overnight, rt

参考文献：

Preparation of tropomyosin receptor kinase degradation compounds and methods of use

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

_75%

反应条件：

1.1 Reagents: Di-tert-butyl dicarbonate Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 30 min, rt
1.2 20 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; pH 8, rt

参考文献：

Optimization of synthetic process of antitumor drug entrectinib

Liu, Yan; Fan, Wei-zheng; Feng, Bai-nian, Huaxue Shiji, 2020, 42(9), 1102-1107

合成路线：1 步

_54%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 30 min, rt
1.2 Solvents: tert-Butanol ; overnight, rt

参考文献：

Indazole compounds for inhibiting kinase activity, their composition and application in field of medical technology

, China, , ,

合成路线：1 步