943-89-5 (4-甲氧基肉桂酸,(E)-3-(4-Methoxyphenyl)acrylic acid)

反应条件：

1.1 Reagents: Tetrabutylammonium hydroxide Solvents: 1,2-Dichloroethane ; 0.5 h, 28 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 7, 28 °C

参考文献：

Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis

Zuo, Yajie; Zhu, Siying; Liu, Yi; Zhao, Jingjing; Zhang, Shiyi; et al, ACS Omega, 2023, 8(7), 7057-7062

合成路线：1 步

57-60-3

_100%

反应条件：

1.1 Solvents: Water ; 16 h, pH 6.5
1.2 Reagents: Hydrogen peroxide ; 30 min, rt
1.3 pH 4

参考文献：

A Type 1 Aldolase, NahE, Catalyzes a Stereoselective Nitro-Michael Reaction: Synthesis of β-Aryl-γ-nitrobutyric Acids

Fansher, Douglas J. ; Palmer, David R. J., Angewandte Chemie, 2023, 62(6),

合成路线：1 步

24393-56-4

_100%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 45 h, 23 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 23 °C

参考文献：

Chromium photocatalysis: accessing structural complements to Diels-Alder adducts with electron-deficient dienophiles

Stevenson, Susan M.; Higgins, Robert F.; Shores, Matthew P.; Ferreira, Eric M., Chemical Science, 2017, 8(1), 654-660

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ

Li, Xin; Sheng, Juzheng; Huang, Guihua; Ma, Ruixin; Yin, Fengxin; et al, European Journal of Medicinal Chemistry, 2015, 97, 32-41

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Phenylacrylamides as novel FtsZ-targeted potential antimicrobials

Li, Xin; Sheng, Juzheng; Song, Di; Guo, Liwei; Ma, Shutao, Letters in Drug Design & Discovery, 2015, 12(3), 234-240

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Palladium Solvents: Dimethylformamide ; 7 h, 90 °C; 90 °C → rt
1.2 Reagents: Sodium carbonate Solvents: Water ; 20 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

Preparation of Pd nanoparticles deposited on a polyaniline/multiwall carbon nanotubes nanocomposite and their application in the Heck reaction

Nie, Guangrui; Zhang, Lei; Cui, Yuanchen, Reaction Kinetics, 2013, 108(1), 193-204

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Triethylenetetramine , Tetrabutylammonium chloride , Palladium Solvents: Dimethylformamide ; 12 h, 120 °C
1.2 Reagents: Sodium carbonate Solvents: Water ; 10 min, cooled

参考文献：

Synthesis of lignin-amine supported palladium catalysts for Heck reaction

Wu, Yufeng; Zhang, Lei; Cui, Yuanchen; Liu, Jiangsheng; Yang, Shuai, Shiyou Huagong, 2009, 38(7), 733-738

合成路线：1 步

1663-39-4

104-92-7

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: (SP-4-4)-Chloro[1,3-dihydro-1,3-bis(2,4,6-trimethylphenyl)-2H-imidazol-2-ylidene… Solvents: N-Methyl-2-pyrrolidone ; 18 h, 140 °C; cooled

参考文献：

N-Heterocycle carbene (NHC)-ligated cyclopalladated N,N-dimethylbenzylamine: A highly active, practical and versatile catalyst for the Heck-Mizoroki reaction

Peh, Guang-Rong; Kantchev, Eric Assen B.; Zhang, Chi; Ying, Jackie Y., Organic & Biomolecular Chemistry, 2009, 7(10), 2110-2119

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Palladium (complexes with 3-cyanopropyltriethoxysilane homopolymer) , Silica , Butanenitrile, 4-(triethoxysilyl)-, homopolymer (palladium complexes) Solvents: Dimethylformamide ; 10.5 h, 100 °C

参考文献：

Organic silica ligated to palladium(0) complex: a highly active and stereoselective catalyst for Heck reaction

Zhao, S. F.; Zhou, R. X.; Yang, Y. F.; Zheng, X. M., Indian Journal of Chemistry, 2002, (11), 2274-2276

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Pyridine , Piperidine Solvents: Pyridine , Piperidine

参考文献：

Synthesis and experimental ionization energies of certain (E)-3-arylpropenoic acids and their methyl esters

Peterson, John R.; Russell, Morley E.; Surjasasmita, Irawan B., Journal of Chemical and Engineering Data, 1988, 33(4), 534-7

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate , Tetrabutylammonium bromide Catalysts: Palladium , Cellulose, ester with N,N′-1,2-ethanediylbis[N-(carboxymethyl)glycine] (palladium complexes) Solvents: Dimethylformamide ; 2 h, 110 °C

参考文献：

Pd immobilized on EDTA-modified cellulose: synthesis, characterization, and catalytic application in inter- and intramolecular Heck reactions and Larock reactions

Xu, Zhian ; Xu, Jinxi ; Zhou, Yuping ; Huang, Yuling ; Li, Yiqun, Research on Chemical Intermediates, 2022, 48(8), 3475-3496

合成路线：1 步

27570-08-7

630-08-0

_99%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: Water , 1-Butyl-3-methylimidazolium hexafluorophosphate ; 10 h, 20 bar, 100 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Stereoselective Hydroxycarbonylation of Vinyl Bromides to α,β-Unsaturated Carboxylic Acids in the Ionic Liquid [BMIM]PF6

Zhao, Xiaodan; Alper, Howard; Yu, Zhengkun, Journal of Organic Chemistry, 2006, 71(10), 3988-3990

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 4 h, 95 °C; 95 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C

参考文献：

Synthesis and spectroscopic analysis of piperine- and piperlongumine-inspired natural product scaffolds and their molecular docking with IL-1β and NF-κB proteins

Zazeri, Gabriel ; Povinelli, Ana Paula R. ; Le Duff, Cecile S. ; Tang, Bridget; Cornelio, Marinonio L. ; et al, Molecules, 2020, 25(12),

合成路线：1 步

867-13-0

_98%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dichloromethane ; 0 °C; 0 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Methanol , Dichloromethane ; 2 h, rt

参考文献：

Process for preparation of cinnamic acid and derivatives thereof

, China, , ,

合成路线：1 步

3095-95-2

_98%

反应条件：

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine , 1,8-Diazabicyclo[5.4.0]undec-7-ene , Zinc triflate Solvents: Tetrahydrofuran ; 12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Mild zinc-promoted Horner-Wadsworth-Emmons reactions of diprotic phosphonate reagents

Schauer, Douglas J.; Helquist, Paul, Synthesis, 2006, (21), 3654-3660

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tripropylamine Catalysts: Triphenylphosphine , Palladium diacetate , 1H-Imidazolium, 3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-heneicosaflu… Solvents: 8-(1,3-Dimethylbutoxy)-1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctane ; 2 h, 120 °C

参考文献：

Mizoroki-Heck Arylation of α,β-Unsaturated Acids with a Hybrid Fluorous Ether, F-626: Facile Filtrative Separation of Products and Efficient Recycling of a Reaction Medium Containing a Catalyst

Fukuyama, Takahide; Arai, Masashi; Matsubara, Hiroshi; Ryu, Ilhyong, Journal of Organic Chemistry, 2004, 69(23), 8105-8107

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Lithium chloride ; 6 min

参考文献：

Microwave-assisted solvent-free synthesis of trans-cinnamic acids using lithium chloride as catalyst

Mogilaiah, K.; Reddy, G. Randheer, Synthetic Communications, 2004, 34(2), 205-210

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Ammonium acetate
1.2 Reagents: Water

参考文献：

Non solvent reaction: ammonium acetate catalyzed highly convenient preparation of trans-cinnamic acids

Kumar, H. M. Sampath; Subbareddy, B. V.; Anjaneyulu, S.; Yadav, J. S., Synthetic Communications, 1998, 28(20), 3811-3815

合成路线：1 步

24680-50-0

_97%

反应条件：

1.1 Reagents: 2-Methyl-2-butene , Monosodium phosphate , Sodium chlorite Solvents: tert-Butanol , Water ; 1 h, 0 °C

参考文献：

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids with 1-Hydroxycyclohexyl Phenyl Ketone

Lu, Yi; Tan, Wen-Yun; Ding, Yuzhen; Chen, Wen ; Zhang, Hongbin, Journal of Organic Chemistry, 2023, 88(13), 8114-8122

合成路线：1 步

104-92-7

_97%