94-48-4 (苯甲酸香叶酯,2,6-Octadien-1-ol,3,7-dimethyl-, 1-benzoate, (2E)-)

_99%

反应条件：

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Diethyl ether ; rt; 20 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Biomimetic syntheses of analogs of Hongoquercin A and B by late-stage derivatization

Mies, Thomas; White, Andrew J. P. ; Parsons, Philip J. ; Barrett, Anthony G. M., Journal of Organic Chemistry, 2021, 86(2), 1802-1817

合成路线：1 步

93-58-3

_99%

反应条件：

1.1 Catalysts: Diethylene glycol monomethyl ether , 2-Propanol, lanthanum(3+) salt Solvents: Hexane ; 1 - 2 min, rt
1.2 3 h, reflux; reflux → rt
1.3 Reagents: Water ; 5 min, rt

参考文献：

Ligand-assisted rate acceleration in lanthanum(III) isopropoxide catalyzed transesterification of carboxylic esters

Hatano, Manabu; Furuya, Yoshiro; Shimmura, Takumi; Moriyama, Katsuhiko; Kamiya, Sho; et al, Organic Letters, 2011, 13(3), 426-429

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Manganese Catalysts: Titanocene dichloride Solvents: 1,4-Dioxane ; 15 min, rt
1.2 Reagents: Diiodomethane Solvents: 1,4-Dioxane ; 2.5 h, rt
1.3 1.5 h, rt

参考文献：

Efficient O-Acylation of Alcohols and Phenol Using Cp2TiCl as a Reaction Promoter

Duran-Pena, Maria Jesus; Botubol-Ares, Jose Manuel; Hanson, James R. ; Hernandez-Galan, Rosario; Collado, Isidro G., European Journal of Organic Chemistry, 2016, 2016(21), 3584-3591

合成路线：1 步

_96%

反应条件：

1.1 Reagents: N,N-Dimethyl-P,P-diphenylphosphinous amide Solvents: Dichloromethane ; 1 h, 40 °C
1.2 Reagents: 2,6-Dimethyl-1,4-benzoquinone Solvents: Dichloromethane ; 1 h, rt

参考文献：

Efficient method for the preparation of carboxylic acid alkyl esters or alkyl phenyl ethers by a new-type of oxidation-reduction condensation using 2,6-dimethyl-1,4-benzoquinone and alkoxydiphenylphosphines

Shintou, Taichi; Kikuchi, Wataru; Mukaiyama, Teruaki, Bulletin of the Chemical Society of Japan, 2003, 76(8), 1645-1667

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triphenylphosphine , Diethyl azodicarboxylate Solvents: Tetrahydrofuran ; 0 °C; rt

参考文献：

Esterification and etherification of steroid and terpene under Mitsunobu conditions

Guezane Lakoud, Samia; Djerourou, Abdelhafid, Arabian Journal of Chemistry, 2016, 9,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; 6 h, rt

参考文献：

Nitrosyl Triflate and Nitrous Anhydride, Same Mode of Generation, but Very Different Reaction Pathways. Direct Synthesis of 1,2-Oxazetes, Nitroso or Bisoxazo Compounds from Olefins

Reddy, G. Sudhakar ; Suh, Elijah J.; Corey, E. J., Organic Letters, 2022, 24(23), 4202-4206

合成路线：1 步

_93%

反应条件：

1.1 Catalysts: Silica ; 2 min

参考文献：

Microwave-assisted solvent-free o-alkylation and acylation of thymol and geraniol using fly ash as solid support

More, D. H.; Hundiwale, D. G.; Kapadi, U. R.; Mahulikar, P. P., Journal of Scientific & Industrial Research, 2006, 65(10), 817-820

合成路线：1 步

769-78-8

_93%

反应条件：

1.1 Catalysts: 1,3-Dihydro-1,3-bis(2,4,6-trimethylphenyl)-2H-imidazol-2-ylidene Solvents: Tetrahydrofuran ; 1 h, rt

参考文献：

Efficient Transesterification/Acylation Reactions Mediated by N-Heterocyclic Carbene Catalysts

Grasa, Gabriela A.; Gueveli, Tatyana; Singh, Rohit; Nolan, Steven P., Journal of Organic Chemistry, 2003, 68(7), 2812-2819

合成路线：1 步

135364-97-5

_92%

反应条件：

1.1 Catalysts: Cesium fluoride Solvents: Acetonitrile ; 15 h, 100 °C

参考文献：

Fluoride-Catalyzed Esterification of Amides

Wu, Hongxiang; Guo, Weijie; Daniel, Stelck; Li, Yue; Liu, Chao; et al, Chemistry - A European Journal, 2018, 24(14), 3444-3447

合成路线：1 步

2902-69-4

_91%

反应条件：

1.1 Catalysts: Pentamethyldiethylenetriamine Solvents: Acetonitrile ; 8 h, 20 - 25 °C

参考文献：

Organocatalytic selective benzoylation of alcohols with trichloromethyl phenyl ketone: inverse selectivity in benzoylation of alcohols containing phenol or aromatic amine functionality

Ram, Ram N.; Soni, Vineet Kumar; Gupta, Dharmendra Kumar, Tetrahedron, 2012, 68(44), 9068-9075

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Water ; rt

参考文献：

A direct approach to amines with remote stereocentres by enantioselective CuH-catalyzed reductive relay hydroamination

Zhu, Shaolin; Niljianskul, Nootaree; Buchwald, Stephen L., Nature Chemistry, 2016, 8(2), 144-150

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Cyanuric chloride Catalysts: 1-Pyrrolidinecarboxaldehyde Solvents: Ethyl acetate ; 4 h, 80 °C; 10 min, 80 °C → rt
1.2 Reagents: 4-Methylmorpholine Catalysts: 4-(Dimethylamino)pyridine Solvents: Ethyl acetate ; 15 min, 0 °C; 0 °C → rt; 6 h, rt

参考文献：

Formamide catalyzed activation of carboxylic acids - versatile and cost-efficient amidation and esterification

Huy, Peter H.; Mbouhom, Christelle, Chemical Science, 2019, 10(31), 7399-7406

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Triphenylphosphine , Iodine Solvents: Dichloromethane
1.2 Reagents: Imidazole
1.3 10 min, rt
1.4 Catalysts: Gadolinium triflate ; 30 min, 50 °C
1.5 3 h, 50 °C
1.6 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Gd(OTf)3-catalyzed synthesis of geranyl esters for the intramolecular radical cyclization of their epoxides mediated by titanocene(III)

Garcia Santos, William H.; Puerto Galvis, Carlos E.; Kouznetsov, Vladimir V., Organic & Biomolecular Chemistry, 2015, 13(5), 1358-1366

合成路线：1 步

5145-65-3

_87%

反应条件：

1.1 Catalysts: 2,2′-Bipyridine , Bis(1,5-cyclooctadiene)nickel Solvents: Toluene ; 18 h, 80 °C

参考文献：

Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions

Chen, Hang; Chen, Dong-Huang; Huang, Pei-Qiang, Science China: Chemistry, 2020, 63(3), 370-376

合成路线：1 步

_85%

参考文献：

Beyond the Tebbe Olefination: Direct Transformation of Esters into Ketones or Alkenes

Domzalska-Pieczykolan, Anna M.; Furman, Bartlomiej, Synlett, 2020, 31(7), 730-736

合成路线：1 步

_78%

反应条件：

1.1 Catalysts: Manganese Solvents: Tetrahydrofuran ; 10 min, rt
1.2 Solvents: Tetrahydrofuran ; 30 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Highly Active Manganese-Mediated Acylation of Alcohols with Acid Chlorides or Anhydrides

Joo, Seong-Ryu; Youn, Young-Jin; Hwang, Young-Ran; Kim, Seung-Hoi, Synlett, 2017, 28(19), 2665-2669

合成路线：1 步

_74%