94-53-1 (胡椒酸,Piperonylic acid)

_100%

反应条件：

1.1 Reagents: Monosodium phosphate , Hydrogen peroxide , Sodium chlorite Solvents: Acetonitrile , Water ; 2 h, 15 °C

参考文献：

Convergent Synthesis of Pancratistatin from Piperonal and Xylose

Dam, Johan Hygum; Madsen, Robert, European Journal of Organic Chemistry, 2009, (27), 4666-4673

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Oxygen Catalysts: Potassium chloride , 1-Butanaminium, N,N,N-tributyl-, ferratehexa-μ3-hydroxyhexa-μ-oxododecaoxohexamo… Solvents: Water ; 24 h, 1 atm, 70 °C

参考文献：

Selective iron-catalyzed aerobic oxidation of alcohols in water to carboxylic acids mediated by additives

Yu, Han; Ren, Jingjing; Xie, Ya; Su, Xiaofang; Wang, Aiping; et al, Green Chemistry, 2022, 24(17), 6511-6516

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium carbonate , Oxygen Catalysts: Molybdate(4-), cupratehexa-μ3-hydroxyhexa-μ-oxododecaoxohexa-, ammonium (1:4) Solvents: Water ; 12 h, 50 °C

参考文献：

An Efficient Aerobic Oxidation Protocol of Aldehydes to Carboxylic Acids in Water Catalyzed by an Inorganic-Ligand-Supported Copper Catalyst

Yu, Han; Ru, Shi; Zhai, Yongyan; Dai, Guoyong; Han, Sheng; et al, ChemCatChem, 2018, 10(6), 1253-1257

合成路线：1 步

551906-15-1

_99%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran , Water ; rt; 12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Accessing N-Acyl Azoles via Oxoammonium Salt-Mediated Oxidative Amidation

Ovian, John M.; Kelly, Christopher B. ; Pistritto, Vincent A.; Leadbeater, Nicholas E., Organic Letters, 2017, 19(6), 1286-1289

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium hydroxide , Benzyltrimethylammonium tribromide Solvents: Water

参考文献：

Oxidation using quaternary ammonium polyhalides. V. Selective oxidation of benzyl alcohols by the use of benzyltrimethylammonium tribromide

Okamoto, Tsuyoshi; Uesugi, Takeshi; Kakinami, Takaaki; Utsunomiya, Tomohisa; Kajigaeshi, Shoji, Bulletin of the Chemical Society of Japan, 1989, 62(11), 3748-9

合成路线：1 步

_98%

反应条件：

1.1 Reagents: 1-Hydroxycyclohexyl phenyl ketone , Sodium hydroxide Solvents: 1,2-Dimethoxyethane ; 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized

参考文献：

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

Tan, Wen-Yun; Lu, Yi; Zhao, Jing-Feng; Chen, Wen; Zhang, Hongbin, Organic Letters, 2021, 23(17), 6648-6653

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Potassium carbonate , Platinum Solvents: Water ; 80 °C

参考文献：

Platinum nanoparticles supported on polymeric ionic liquid functionalized magnetic silica: effective and reusable heterogeneous catalysts for the selective oxidation of alcohols in water

Vessally, Esmail; Ghasemisarabbadeih, Mostafa; Ekhteyari, Zeynab; Hosseinzadeh-Khanmiri, Rahim; Ghorbani-Kalhor, Ebrahim; et al, RSC Advances, 2016, 6(108), 106769-106777

合成路线：1 步

_98%

反应条件：

1.1 Reagents: 1,5,7-Triazabicyclo[4.4.0]dec-5-ene , Oxygen Catalysts: 5H-Pyrrolo[2,1-c]-1,2,4-triazolium, 6,7-dihydro-2-(2,4,6-trimethylphenyl)-, tetr… Solvents: Acetonitrile ; 1 - 24 h, rt

参考文献：

Cooperative N-heterocyclic carbene (NHC) and ruthenium redox catalysis: Oxidative esterification of aldehydes with air as the terminal oxidant

Zhao, Junfeng; Mueck-Lichtenfeld, Christian; Studer, Armido, Advanced Synthesis & Catalysis, 2013, 355(6), 1098-1106

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 1-Hydroxycyclohexyl phenyl ketone , Sodium hydroxide Solvents: 1,2-Dimethoxyethane ; 80 °C; 80 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids with 1-Hydroxycyclohexyl Phenyl Ketone

Lu, Yi; Tan, Wen-Yun; Ding, Yuzhen; Chen, Wen ; Zhang, Hongbin, Journal of Organic Chemistry, 2023, 88(13), 8114-8122

合成路线：1 步

124-38-9

2635-13-4

_96%

反应条件：

1.1 Reagents: Poly(methylhydrosiloxane) Catalysts: Cupric acetate , 1,2-Bis(diphenylphosphino)benzene Solvents: 1,4-Dioxane ; 25 min, 60 °C
1.2 Reagents: Triethylamine Catalysts: Palladium diacetate , 1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ; 3 h, 100 °C; 100 °C → rt
1.3 Reagents: Sodium hydroxide Solvents: Water ; 10 min, rt
1.4 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2

参考文献：

Method for preparing aromatic carboxylic acid compound

, China, , ,

合成路线：1 步

124-38-9

2635-13-4

_96%

反应条件：

1.1 Reagents: Poly(methylhydrosiloxane) Catalysts: Cupric acetate , 1,2-Bis(diphenylphosphino)benzene Solvents: 1,4-Dioxane ; 20 min, rt → 65 °C
1.2 Reagents: Triethylamine Catalysts: Palladium diacetate , 1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ; 3 h, rt → 100 °C; 100 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; 10 min, rt

参考文献：

Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

Paridala, Kumaraswamy; Lu, Sheng-Mei; Wang, Meng-Meng; Li, Can, Chemical Communications (Cambridge, 2018, 54(82), 11574-11577

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sodium hydroxide , Permanganic acid (HMnO4), potassium salt (1:1) Catalysts: Tetramethylammonium bromide Solvents: Water ; pH 9, 25 - 30 °C; 30 °C → 45 °C; 3 h, 40 - 45 °C

参考文献：

Method for preparation of piperonylic acid with heliotropine by phase transfer catalysis oxidation

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: 2-Methyl-2-butene , Sodium phosphate , Sodium chlorite Solvents: tert-Butanol , Water ; 2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

A Domino Amidation Route to Indolines and Indoles: Rapid Syntheses of Anhydrolycorinone, Hippadine, Oxoassoanine, and Pratosine

Ganton, Michael D.; Kerr, Michael A., Organic Letters, 2005, 7(21), 4777-4779

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: Poly(oxy-1,2-ethanediyl), α-[2-[1-(3-sulfopropyl)-1H-imidazolium-3-yl]ethyl]-ω-[… Solvents: Toluene , Water ; rt; 4 h, 85 °C

参考文献：

PEG1000-DAIL/toluene temperature-dependent biphasic system that regulate homogeneously catalyzed oxidation of primary alcohols to carboxylic acids

Hu, Yu Lin; Ma, Xiao Yun; Ge, Qiang; Lu, Ming, Acta Chimica Slovenica, 2010, 57(4), 927-930

合成路线：1 步

120-58-1

_95%

反应条件：

1.1 Solvents: Water ; 30 °C
1.2 Reagents: Sulfuric acid ; pH 2

参考文献：

Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants

Shimoni, Eyal; Baasov, Timor; Ravid, Uzi; Shoham, Yuval, Journal of Biotechnology, 2003, 105, 61-70

合成路线：1 步

7145-99-5

_94%

反应条件：

1.1 Reagents: Potassium persulfate , Oxygen Catalysts: Molybdate(3-), chromatehexa-μ3-hydroxyhexa-μ-oxododecaoxohexa-, ammonium (1:3) Solvents: Water ; 24 h, 50 °C

参考文献：

An efficient chromium(III)-catalyzed aerobic oxidation of methylarenes in water for the green preparation of corresponding acids

Jiang, Feng; Liu, Shanshan; Zhao, Wenshu; Yu, Han; Yan, Likai; et al, Dalton Transactions, 2021, 50(36), 12413-12418

合成路线：1 步

94839-07-3

141-97-9

_94%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Cuprous iodide Solvents: Dimethyl sulfoxide ; 24 h, 100 °C; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Copper-catalyzed synthesis of aromatic carboxylic acids from arylboronic acids and acetyl acetate

Zheng, Rui; Zhou, Qizhong; Gu, Haining; Jiang, Huajiang; Wu, Jiashou; et al, Tetrahedron Letters, 2014, 55(41), 5671-5675

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: 2069173-90-4 Solvents: Toluene ; 12 h, 120 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts

Yin, Shenxiang; Zheng, Qingshu; Chen, Jie; Tu, Tao, Journal of Catalysis, 2022, 408, 165-172

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Water Catalysts: Tris(2,2′-bipyridyl)ruthenium(II) chloride Solvents: Acetonitrile ; 3 h, 10 bar, rt

参考文献：

Visible-Light-Mediated Hydroxycarbonylation of Diazonium Salts

Gosset, Cyrille; Pellegrini, Sylvain; Jooris, Romain; Bousquet, Till; Pelinski, Lydie, Advanced Synthesis & Catalysis, 2018, 360(17), 3401-3405

合成路线：1 步

_92%