94608-23-8 (顺式白藜芦醇三甲醚,cis-trismethoxy Resveratrol (Solution in Ethanol))

反应条件：

1.1 Solvents: Ethanol ; 1 h, rt

参考文献：

Anti-mitotic properties of resveratrol analog (Z)-3,5,4'-trimethoxystilbene

Chabert, Philippe; Fougerousse, Andre; Brouillard, Raymond, BioFactors, 2006, 27(1-4), 37-46

合成路线：1 步

22255-22-7

_100%

反应条件：

1.1 Solvents: Ethanol ; 1 h

参考文献：

Method for the synthesis of (Z)-3,5,4'-trimethoxystilbene, a trimethyl derivative of resveratrol, the resulting compound, and uses of said compound, in particular as a medicine, and particularly as an anticancer drug

, World Intellectual Property Organization, , ,

合成路线：1 步

7311-34-4

1530-38-7

_99%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Isopropanol ; 60 °C

参考文献：

E-selective isomerization of stilbenes and stilbenoids through reversible hydroboration

Gray, Erin E.; Rabenold, Lake E.; Goess, Brian C., Tetrahedron Letters, 2011, 52(46), 6177-6179

合成路线：1 步

_93%

反应条件：

1.1 Reagents: 1,10-Phenanthroline , Quinoline , Copper ; 50 min, heated
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6, cooled

参考文献：

Method for preparing diphenylethylene from 2,3-diphenyl acrylic acid

, China, , ,

合成路线：1 步

441351-32-2

74-88-4

_92%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 5 h, reflux

参考文献：

Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers

Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(22), 5767-5772

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Chromium copper oxide (Cr2CuO4) Solvents: Pyridine ; rt → 240 °C; 1 - 2 h, 230 - 240 °C; 240 °C → rt

参考文献：

Improved method for synthesizing resveratrol

, China, , ,

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Lithium tert-butoxide , Bis(neopentyl glycolato)diboron Catalysts: (2-Thiophenecarboxylato-κO2,κS1)copper , 1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Dimethylformamide , Water ; 24 h, 60 °C

参考文献：

Copper-catalysed, diboron-mediated cis-dideuterated semihydrogenation of alkynes with heavy water

Han, Xiaowei; Hu, Jiefeng; Chen, Cheng; Yuan, Yu; Shi, Zhuangzhi, Chemical Communications (Cambridge, 2019, 55(48), 6922-6925

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Chlorotrimethylsilane , Hydrogen , Magnesium Catalysts: (OC-6-31)-Aqua[1-[2,6-bis(1-methylethyl)phenyl]-3-[1-[[2,6-bis(1-methylethyl)phe… Solvents: Tetrahydrofuran ; 24 h, 90 - 100 °C

参考文献：

Chromium-catalyzed stereodivergent E- and Z-selective alkyne hydrogenation controlled by cyclic (alkyl)(amino)carbene ligands

Ling, Liang ; Hu, Chenyang ; Long, Linhong; Zhang, Xue ; Zhao, Lixing ; et al, Nature Communications, 2023, 14(1),

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Deuterium , [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]hydroxy… Catalysts: 1,1-Bis(diphenylphosphino)ferrocene , Nickel iodide (NiI2) Solvents: Tetrahydrofuran ; 100 bar, 60 °C

参考文献：

A simple nickel catalyst enables broad E-selective alkyne semihydrogenation

Thiel, Niklas O.; Kaewmee, Benyapa; Ngoc, Trung Tran; Teichert, Johannes F., ChemRxiv, 2019, 1, 1-7

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Quinoline , Sodium hydroxide Catalysts: Copper ; 0.25 h, 200 °C

参考文献：

Synthesis of resveratrol

Hou, Bing-bo; Feng, Jiang-jiang; Yang, Sheng-wei; Ao, Gui-zhen, Huaxue Shiji, 2011, 33(12), 1141-1143

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Quinoline , Potassium hydroxide , Copper bromide (CuBr) ; 0.5 h, 190 °C

参考文献：

Method for preparation of (E)-Resveratrol

, China, , ,

合成路线：1 步

_76%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Copper oxide (Cu2O) Solvents: N-Methyl-2-pyrrolidone ; 90 min, 200 °C

参考文献：

Stereospecific synthesis of cis-stilbenes from benzaldehydes and phenylacetic acids via sequential Perkin condensation and decarboxylation

Thompson, Clayton M.; Orellana, Matthew D.; Lloyd, Shannon E.; Wu, Weiming, Tetrahedron Letters, 2016, 57(43), 4866-4868

合成路线：1 步

1312815-39-6

20469-65-2

_76%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Palladium diacetate , 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl Solvents: Tetrahydrofuran ; 6 h, 23 °C

参考文献：

(Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis

Woerly, Eric M.; Struble, Justin R.; Palyam, Nagarjuna; O'Hara, Sean P.; Burke, Martin D., Tetrahedron, 2011, 67(24), 4333-4343

合成路线：1 步

909717-00-6

_74%

反应条件：

1.1 Reagents: Quinoline Catalysts: Copper ; 3 h, 220 °C

参考文献：

Efficient synthesis of natural polyphenolic stilbenes: resveratrol, piceatannol and oxyresveratrol

Sun, Hong-Yi; Xiao, Chun-Fen; Cai, Yu-Chen; Chen, Yu; Wei, Wen; et al, Chemical & Pharmaceutical Bulletin, 2010, 58(11), 1492-1496

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Quinoline , Copper Catalysts: 1,10-Phenanthroline ; 6 min
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Microwave-assisted and ligand-accelerated decarboxylation of 2,3-diaryl acrylic acids

Liu, Xianke; Wu, Wei; Lv, Zeliang; Zou, Yong, Huaxue Tongbao, 2012, 75(6), 526-531

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Quinoline , Copper ; 3 h, 200 °C

参考文献：

Hydroxyl Substitutional Effect on Selective Synthesis of cis, trans Stilbenes and 3-Arylcoumarins Through Perkin Condensation

Xiao, Chun-Fen; Zou, Yong; Du, Jian-Li; Sun, Hong-Yi; Liu, Xian-Ke, Synthetic Communications, 2012, 42(9), 1243-1258

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Copper Solvents: Quinoline ; 4 h, 220 °C

参考文献：

An efficient synthesis of resveratrol and a hydroxyl derivative via the perkin reaction: cis to trans isomerization in a demethylation process

Li, Guoxing; Zou, Yong; Zhang, Xuejing, Journal of Chemical Research, 2007, (11), 657-659

合成路线：1 步

1229971-87-2

696-62-8

_56%

反应条件：

1.1 Reagents: Diisobutylaluminum hydride Solvents: Diethyl ether ; 0 °C; 0 °C → rt; 16 h, rt
1.2 Reagents: Tetrabutylammonium fluoride Catalysts: Bis(dibenzylideneacetone)palladium Solvents: Tetrahydrofuran

参考文献：

Diversity-oriented synthesis of disubstituted alkenes using masked silanols

Sore, Hannah F.; Blackwell, David T.; MacDonald, Simon J. F.; Spring, David R., Organic Letters, 2010, 12(12), 2806-2809

合成路线：1 步

1530-38-7

7311-34-4

_54%

反应条件：

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C; 30 min, -78 °C; 1 h, rt; rt → -78 °C
1.2 Solvents: Tetrahydrofuran ; 1 h, -78 °C; 18 h, rt

参考文献：

2-Amino and 2'-Aminocombretastatin Derivatives as Potent Antimitotic Agents

Chang, Jang-Yang; Yang, Ming-Fang; Chang, Chi-Yen; Chen, Chi-Ming; Kuo, Ching-Chuan; et al, Journal of Medicinal Chemistry, 2006, 49(21), 6412-6415

合成路线：1 步

_45%