94838-58-1 ((4-硝基苄基)氨基甲酸叔丁酯,tert-Butyl 4-nitrobenzylcarbamate)

_100%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 3 h, reflux

参考文献：

Preparation of 3,4-diphenyl-4H-1,2,4-triazole derivatives as inhibitor of HSP90

, China, , ,

合成路线：1 步

840494-08-8

_100%

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane , Water ; 3 h, rt

参考文献：

A facile synthesis of primary and secondary amines

Lankiewicz, L.; Roj, A.; Szymanska, A.; Wiczk, W., Polish Journal of Chemistry, 2004, 78(8), 1067-1072

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran , Water ; rt → 0 °C; 0 °C; 20 h, 0 °C → 25 °C

参考文献：

Preparation of sulfonyl amide derivatives for the treatment of abnormal cell growth

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane

参考文献：

Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects

Suh, Young-Ger; Lee, Yong-Sil; Min, Kyung-Hoon; Park, Ok-Hui; Seung, Ho-Sun; et al, Bioorganic & Medicinal Chemistry Letters, 2003, 13(24), 4389-4393

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ; 90 min, rt

参考文献：

Oxidative Approach Enables Efficient Access to Cyclic Azobenzenes

Maier, Martin S.; Huell, Katharina; Reynders, Martin; Matsuura, Bryan S.; Leippe, Philipp; et al, Journal of the American Chemical Society, 2019, 141(43), 17295-17304

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; 2 h, 25 °C

参考文献：

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, Sveva; Brancale, Andrea; et al, European Journal of Medicinal Chemistry, 2014, 80, 101-111

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; rt
1.2 3 h, rt

参考文献：

Preparation of quinolines and quinazolines as inhibitors of c-Met and other tyrosine kinases and therapeutic uses against proliferative diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; 16 h, 0 °C

参考文献：

Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase

Goodyer, Claire L. M.; Chinje, Edwin C.; Jaffar, Mohammed; Stratford, Ian J.; Threadgill, Michael D., Bioorganic & Medicinal Chemistry, 2003, 11(19), 4189-4206

合成路线：1 步

41840-28-2

_91%

反应条件：

1.1 Reagents: Triethylamine Solvents: 1,4-Dioxane , Water

参考文献：

A new method for the synthesis of amides from amines: ruthenium tetroxide oxidation of N-protected alkylamines

Tanaka, Kenichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro, Chemical & Pharmaceutical Bulletin, 1988, 36(8), 3125-9

合成路线：1 步

1314538-55-0

100-00-5

_90%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate , 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl Solvents: Toluene , Water ; 22 h, 85 °C

参考文献：

Synthesis and Suzuki-Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Heteroaryl Halides

Molander, Gary A.; Shin, Inji, Organic Letters, 2011, 13(15), 3956-3959

合成路线：1 步

62133-07-7

_87%

反应条件：

1.1 Solvents: Ethyl acetate ; 1 h, rt
1.2 Solvents: Toluene ; heated; rt; rt → 0 °C; 2 h, 0 °C

参考文献：

Tricyclic Indole-2-carboxylic Acids: Highly in Vivo Active and Selective Antagonists for the Glycine Binding Site of the NMDA Receptor

Katayama, Seiji; Ae, Nobuyuki; Kodo, Toru; Masumoto, Shuji; Hourai, Shinji; et al, Journal of Medicinal Chemistry, 2003, 46(5), 691-701

合成路线：1 步

17271-88-4

_86%

反应条件：

1.1 Reagents: Decaborane Catalysts: Palladium Solvents: Methanol ; 4.5 h, rt

参考文献：

Chemoselective conversion of azides to t-butyl carbamates and amines

Jung, Yeon Joo; Chang, Yu Mi; Lee, Ji Hee; Yoon, Cheol Min, Tetrahedron Letters, 2002, 43(48), 8735-8739

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Triethylamine Solvents: Ethanol ; 4 h, rt

参考文献：

Azobenzene-based chloride transporters with light-controllable activities

Choi, Ye Rin; Kim, Gyu Chan; Jeon, Hae-Geun; Park, Jinhong; Namkung, Wan; et al, Chemical Communications (Cambridge, 2014, 50(97), 15305-15308

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ; 0 °C; 1 h, 25 °C
1.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

Preparation of benzazepine dicarboxamide as TLR8 agonists for treatment of autoimmune disease, cancer, and other diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Triethylamine Solvents: Toluene ; 15 min, rt; 2 h, 60 °C; 16 h, rt

参考文献：

Novel diamine, polyamic acid therewith, and polyimide therefrom

, World Intellectual Property Organization, , ,

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane

参考文献：

Novel lipoic acid analogues that inhibit nitric oxide synthase

Harnett, Jeremiah J.; Auguet, Michel; Viossat, Isabelle; Dolo, Christine; Bigg, Dennis; et al, Bioorganic & Medicinal Chemistry Letters, 2002, 12(11), 1439-1442

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; 18 h, rt

参考文献：

Photoresponsive Supramolecular Architectures Based on Polypeptide Hybrids

Mazzier, Daniela; Maran, Marco; Polo Perucchin, Omar; Crisma, Marco; Zerbetto, Mirco; et al, Macromolecules (Washington, 2014, 47(21), 7272-7283

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran , Water ; rt; 16 h, rt

参考文献：

Preparation of benzazepines, benzodiazepines, and analogs as fibrinogen antagonists

, United States, , ,

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 3 h, rt

参考文献：

Preparation of novel thioureas as modulators for vanilloid receptor (VR)

, World Intellectual Property Organization, , ,

合成路线：1 步

1314538-55-0

1142-27-4

_60%