94838-59-2 ([2-(4-氨基苯基)乙基]丙二酸叔丁酯,N-Boc-4-aminophenethylamine)

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl acetate ; overnight, rt

参考文献：

Interleukin 8 receptor antagonist benzamide compounds, their preparation, and their therapeutic use

, World Intellectual Property Organization, , ,

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Thiamine hydrochloride ; 3 min, rt

参考文献：

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Ingale, Ajit P. ; Garad, Dnyaneshwar N. ; Ukale, Dattatraya ; Thorat, Nitin M. ; Shinde, Sandeep V., Synthetic Communications, 2021, 51(24), 3791-3804

合成路线：1 步

144226-16-4

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; overnight, rt

参考文献：

Methods and compositions for targeted protein degradation

, World Intellectual Property Organization, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 16 h, rt

参考文献：

Pesticidal compositions and methods

, World Intellectual Property Organization, , ,

合成路线：1 步

24954-67-4

_98%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; rt → 0 °C
1.2 1 h, rt
1.3 Reagents: Hydrazine hydrate (1:1) Catalysts: Nickel Solvents: Ethanol ; 1 h, 50 °C

参考文献：

Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators

Nguyen, Thuy; German, Nadezhda; Decker, Ann M.; Li, Jun-Xu; Wiley, Jenny L.; et al, Bioorganic & Medicinal Chemistry, 2015, 23(9), 2195-2203

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt; 2 h, rt

参考文献：

Controlling epithelial sodium channels with light using photoswitchable amilorides

Schoenberger, Matthias; Althaus, Mike; Fronius, Martin; Clauss, Wolfgang; Trauner, Dirk, Nature Chemistry, 2014, 6(8), 712-719

合成路线：1 步

_98%

反应条件：

1.1 Solvents: 1,4-Dioxane ; 30 min, rt; 22 h, rt

参考文献：

Preparation of nitroarginine derivatives as selective neuronal nitric oxide synthase inhibitors

, United States, , ,

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 0 °C; 1 h, rt

参考文献：

Preparation of imidazolylphenylethylaminocarbonylbenzenesulfonamides and related compounds as antiinflammatory and analgesic agents.

, World Intellectual Property Organization, , ,

合成路线：1 步

_98%

反应条件：

1.1 Solvents: 1,4-Dioxane ; 30 min, rt; 22 h, rt

参考文献：

Preparation of peptidomimetic compounds as selective neuronal nitric oxide synthase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: 1,1,1,3,3,3-Hexabromo-2-propanone Solvents: Dichloromethane ; 5 min, rt

参考文献：

NBS and Br3CCOCBr3 as highly efficient catalysts for the chemoselective N-tert-butyloxycarbonylation of amines

Chantarasriwong, Oraphin ; Jiangchareon, Banphot; Putra, Christian Kurnia; Suwankrua, Winai; Chavasiri, Warinthorn, Tetrahedron Letters, 2016, 57(43), 4807-4811

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt; 2 h, rt

参考文献：

Natural lignin nanoparticles: a promising nano-crosslinker for constructing fluorescent photoswitchable supramolecular hydrogels

Gu, Lianghong; Liu, Xue; Dong, Shumin; Chen, Zhijun; Han, Rui; et al, Polymer Chemistry, 2020, 11(11), 1871-1876

合成路线：1 步

144226-16-4

_95%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 2 h, 3 psi, rt

参考文献：

Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

Piscitelli, Francesco; Ligresti, Alessia; La Regina, Giuseppe; Coluccia, Antonio; Morera, Ludovica; et al, Journal of Medicinal Chemistry, 2012, 55(11), 5627-5631

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Methanol ; 24 h, rt

参考文献：

Preparation of novel multi-binding phenolic compounds as β2-adrenergic receptor agonists

, United States, , ,

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Methanol ; 24 h, rt

参考文献：

Preparation of novel multibinding phenolic compounds as β2-adrenergic receptor agonists

, World Intellectual Property Organization, , ,

合成路线：1 步

_94%

反应条件：

1.1 Solvents: Tetrahydrofuran , Ethyl acetate ; 30 min, 23 °C; 4 h, 23 °C

参考文献：

Novel bis-amide containing compounds exhibiting antifungal activity and their method of use and preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; overnight, rt

参考文献：

Preparation of sulfonylaminomethyl five-membered heterocyclic carboxamide derivatives as bradykinin B1 antagonists and their preparation, pharmaceutical compositions and use in the treatment of inflammatory-related disorders

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Solvents: Dichloromethane

参考文献：

4-Aminopiperidine ureas as potent selective agonists of the human β3-Adrenergic receptor

Ashwell, Mark A.; Solvibile, William R.; Han, Stella; Largis, Elwood; Mulvey, Ruth; et al, Bioorganic & Medicinal Chemistry Letters, 2001, 11(24), 3123-3127

合成路线：1 步

_91%