94994-39-5 (5-羟基甲基异噁唑-3-羧酸乙酯,4-{(tert-butoxy)carbonyl(methyl)amino}butanoic acid)

_100%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 72 h, rt

参考文献：

Preparation of substituted quinolinone derivatives for use as muscarinic receptor antagonists and β2 adrenergic receptor agonists

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Solvents: Isopropanol , Acetonitrile ; overnight, rt

参考文献：

Preparation of carbamate prodrugs for inhibition of inosine monophosphate dehydrogenase (IMPDH)

, World Intellectual Property Organization, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; 10 min, rt; 1 h, rt

参考文献：

Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules

, World Intellectual Property Organization, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 5 min, 0 °C; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3
1.3 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 2 h, 0 °C
1.4 Solvents: Water ; 0 °C
1.5 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3

参考文献：

Fragment-based domain shuffling approach for the synthesis of pyran-based macrocyclic compounds

Comer, Eamon; Liu, Haibo; Joliton, Adrien; Clabaut, Alexandre; Johnson, Christopher; et al, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(17), 6751-6756

合成路线：1 步

57294-38-9

74-88-4

_93%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; rt → 0 °C; 16 h, rt
1.2 Reagents: Water ; rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3, rt

参考文献：

Antibody drug conjugates comprising STING modulators

, World Intellectual Property Organization, , ,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ; 0 °C; 24 h, rt

参考文献：

Aminopropyl thiazole derivatives useful as fungicides, and their preparation procedures

, Germany, , ,

合成路线：1 步

1119-48-8

_93%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Dichloromethane , Water ; 48 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 5, rt

参考文献：

Peptoads, a group of amphiphilic long-chain triamides

Menger, Fredric M.; Zhang, Hailing, Langmuir, 2005, 21(23), 10428-10438

合成路线：1 步

57294-38-9

74-88-4

_92%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran

参考文献：

Total Synthesis of Cyclosporin on Solid-Phase Support

Gerber, Andreas, 2009, , ,

合成路线：1 步

57294-38-9

74-88-4

_73%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 6 h, 0 °C
1.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water ; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Design, synthesis, and cyclization of 4-aminobutyric acid derivatives: potential candidates as self-immolative spacers

DeWit, Matthew A.; Gillies, Elizabeth R., Organic & Biomolecular Chemistry, 2011, 9(6), 1846-1854

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; 10 min, rt; 22 h, rt

参考文献：

DC-SiGN antibody conjugates comprising STING receptor agonists and their use in cancer therapy

, World Intellectual Property Organization, , ,

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; 10 min, rt; 22 h, rt

参考文献：

Antibody conjugates comprising sting agonist

, World Intellectual Property Organization, , ,

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane , Water ; 20 min, 0 °C; 22 h, rt

参考文献：

Preparation of chemokine receptor binding (benzimidazol-2-ylmethyl)(5,6,7,8-tetrahydroquinolin-8-yl)amines and related heterocyclic compounds with enhanced efficacy against AIDS and other disorders

, United States, , ,

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ; 16 h, rt → 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3 - 4

参考文献：

Lipid compound for cell transfection, and liposome and pharmaceutical composition comprising the same for treating genetic abnormality-induced disease

, China, , ,

合成路线：1 步

872-50-4

_52%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 18 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 10 min, rt; rt → 0 °C
1.3 30 min, 0 °C; 12 h, rt

参考文献：

Synthesis and evaluation of xanomeline analogs-Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor

Kane, Brian E.; Grant, Marianne K. O.; El-Fakahany, Esam E.; Ferguson, David M., Bioorganic & Medicinal Chemistry, 2008, 16(3), 1376-1392

合成路线：1 步

872-50-4

_42%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 16 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran , Water ; 14 h, rt

参考文献：

Preparation of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as β-lactamase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; rt; 2 h, rt

参考文献：

(R)-N-ethyl-5-fluoro-N-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-m ethylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

1119-48-8

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; rt; 2 d, rt

参考文献：

Synthesis of Pyridazines or 1,2,4-Triazines containing spirocyclic amines treating cancers and diabetes

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; rt; 2 h, rt

参考文献：

Preparation of substituted spiro derivatives, especially, (R)-N-ethyl-5-fluoro-N-isopropyl-2-[[5-[2-[6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl]-2,6-diazaspiro[3.4]octan-6-yl]-1,2,4-triazin-6-yl]oxy]benzami de and its dibesylate as inhibitors of menin-MLL interaction and their use in combination with a BCl-2 inhibitor and optionally one other antitumor agents

, World Intellectual Property Organization, , ,

合成路线：1 步