95091-92-2 (N-甲氧基-N-甲基-2-糠酰胺,N-Methoxy-N-methyl-2-furancarboxamide)

_99%

反应条件：

1.1 Solvents: Toluene ; 10 min, 0 °C
1.2 Reagents: Phosphorus trichloride Solvents: Toluene ; 0 °C; 0 °C → rt; 0.5 h, 60 °C; 60 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; Wang, Ke-Hu; Huang, Danfeng; Xu, Changming; Su, Yingpeng; et al, Synthesis, 2014, 46(3), 320-330

合成路线：1 步

611-13-2

_99%

反应条件：

1.1 Catalysts: Chlorodimethylaluminum Solvents: Dichloromethane

参考文献：

Efficient method for preparation of N-methoxy-N-methyl amides by reaction of lactones or esters with Me2AlCl-MeONHMe·HCl

Shimizu, Takeshi; Osako, Katsuhisa; Nakata, Tadashi, Tetrahedron Letters, 1997, 38(15), 2685-2688

合成路线：1 步

1062512-43-9

_96%

反应条件：

1.1 Solvents: Toluene ; 0.5 - 1 h, 60 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; Zhang, Weiming; Huang, Danfeng; Xu, Changming; Wang, Haifeng; et al, Organic Letters, 2009, 11(19), 4474-4477

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane

参考文献：

Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis-reductive cyclization

Gebauer, Julian; Dewi, Purnama; Blechert, Siegfried, Tetrahedron Letters, 2005, 46(1), 43-46

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Oxalyl chloride Solvents: Dimethylformamide , Dichloromethane ; 1.5 h, rt
1.2 Reagents: Triethylamine Solvents: Dichloromethane ; 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Versatile Synthesis of Acylfuranones by Reaction of Acylketenes with α-Hydroxy Ketones: Application to the One-Step Multicomponent Synthesis of Cadiolide B and Its Analogues

Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier, European Journal of Organic Chemistry, 2013, 2013(16), 3316-3327

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ; 0 °C; 2 h, rt
1.2 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; overnight, rt

参考文献：

Palladium-Catalyzed Borylative Cyclizations of α-(2-Bromoaryl) Ketones to Form 1,2-Benzoxaborinines

Shigeno, Masanori ; Iseya, Yuto; Kume, Ryotaro; Nozawa-Kumada, Kanako ; Kondo, Yoshinori, Organic Letters, 2022, 24(39), 7227-7231

合成路线：1 步

_93%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine , S,S-Di-2-pyridinyl carbonodithioate Solvents: Acetonitrile
1.2 Reagents: Triethylamine
1.3 Solvents: Tetrahydrofuran
1.4 Solvents: Hexane , Ethyl acetate

参考文献：

A convenient synthesis of N-methoxy-N-methylamides from carboxylic acids using S,S-di-2-pyridyl dithiocarbonate

Lee, Jae In; Park, Hyun, Bulletin of the Korean Chemical Society, 2001, 22(4), 421-423

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Oxalyl chloride , Diphenylcyclopropenone Solvents: Dichloromethane
1.2 Reagents: Diisopropylethylamine ; rt
1.3 Solvents: Dichloromethane ; rt

参考文献：

One-pot synthesis of Weinreb amides employing 3,3-dichloro-1,2-diphenylcyclopropene (CPI-Cl) as a chlorinating agent

M, Shekharappa; Kumar L, Roopesh; Sureshbabu, Vommina V., Synthetic Communications, 2019, 49(6), 790-798

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Triethylamine , Propylphosphonic anhydride Solvents: Tetrahydrofuran , Ethyl acetate ; 10 min, 0 - 5 °C
1.2 0 - 5 °C; 80 min, 25 °C

参考文献：

A new strategy for accessing (S)-1-(furan-2-yl)pent-4-en-1-ol: a key precursor of Ipomoeassin family of compounds and C1-C15 domain of halichondrins

Jammula, Subba Rao; Anna, Venkateswara Rao; Tatina, Sudhakar; Krishna, Thalishetti; Sreenivas, B. Yogi; et al, Tetrahedron Letters, 2016, 57(35), 3924-3928

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium bicarbonate Solvents: 2-Methyltetrahydrofuran , Water ; 2 min, 0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized, rt

参考文献：

Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

Pace, Vittorio; Castoldi, Laura; Alcantara, Andres R.; Holzer, Wolfgang, RSC Advances, 2013, 3(26), 10158-10162

合成路线：1 步

_91%

反应条件：

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ; 1 h, rt
1.2 Reagents: Triethylamine ; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; 10 min, rt

参考文献：

A CO2-Catalyzed Transamidation Reaction

Yang, Yang ; Liu, Jian; Kamounah, Fadhil S.; Ciancaleoni, Gianluca ; Lee, Ji-Woong, Journal of Organic Chemistry, 2021, 86(23), 16867-16881

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Diisopropylethylamine , Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trime… Solvents: Water ; 0.5 - 3 h, 0 °C

参考文献：

Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M

Shi, Min; Ye, Ning; Chen, Wei; Wang, Hui; Cheung, Chiming ; et al, Organic Process Research & Development, 2020, 24(8), 1543-1548

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; 0 °C → rt; 1 h, rt

参考文献：

A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

Firth, James D.; Craven, Philip G. E.; Lilburn, Matthew; Pahl, Axel; Marsden, Stephen P.; et al, Chemical Communications (Cambridge, 2016, 52(63), 9837-9840

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Trichloroacetamide , Triphenylphosphine Solvents: Dichloromethane ; rt; 1 h, rt
1.2 Reagents: Triethylamine ; rt; 1 h, rt

参考文献：

A convenient one-pot method for the synthesis of N-methoxy-N-methyl amides from carboxylic acids

Kim, Joong-Gon; Jang, Doo Ok, Bulletin of the Korean Chemical Society, 2010, 31(1), 171-173

合成路线：1 步

_87%

反应条件：

1.1 Solvents: Chloroform ; rt → 0 °C
1.2 Reagents: Pyridine ; 0 °C; 15 min, 0 °C; overnight, 0 °C → rt

参考文献：

Method of making 2-furyl alkyl ketones

, United States, , ,

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 10 min, 0 °C; overnight, rt

参考文献：

Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and In Situ Alcoholysis

Luo, Wenkun ; Jiang, Kai; Li, Yingwei ; Jiang, Huanfeng ; Yin, Biaolin, Organic Letters, 2020, 22(5), 2093-2098

合成路线：1 步

611-13-2

_85%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 5 min, -20 °C
1.2 Reagents: Chloro(1-methylethyl)magnesium Solvents: Diethyl ether ; 15 min, -20 °C; 10 min, -20 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ; -20 °C → 18 °C; 10 min, 18 °C

参考文献：

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation

Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B., Organic & Biomolecular Chemistry, 2013, 11(20), 3337-3340

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 0 °C; 12 h, 0 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Palladium-Catalyzed Hydrocarbonylative Cyclization of 1,5-Dienes

Zou, Suchen; Gao, Bao; Huang, Yao; Zhang, Tianze; Huang, Hanmin, Organic Letters, 2019, 21(16), 6333-6336

合成路线：1 步

30289-28-2

_81%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile

参考文献：

An efficient synthesis of N-methoxy-N-methylamides from carboxylic acids using N-methoxy-N-methylcarbamoyl chloride

Lee, Jae In; Park, Hyun, Bulletin of the Korean Chemical Society, 2002, 23(3), 521-524

合成路线：1 步

_79%