951380-42-0 (5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-4,5,6,7-四氢噻吩并[3,2-c]吡啶-2(3H)-酮,5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2(3H)-one)

反应条件：

1.1 Reagents: Acetic acid Solvents: Ethanol ; pH 5, rt
1.2 Reagents: Hydrogen peroxide Solvents: Water ; 4 h, rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ; rt

参考文献：

An improvement to the preparation of prasugrel hydrochloride

Ou, Wenhua; Yi, Weiyin; Liu, Feng; Pan, Xianhua; Peng, Xijiang, Journal of Chemical Research, 2013, 37(6), 369-371

合成路线：1 步

1100905-46-1

_82%

反应条件：

1.1 Reagents: Potassium bicarbonate Solvents: Acetonitrile ; rt → 40 °C
1.2 3 h, 40 °C

参考文献：

Process for preparation of 2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethanol derivatives as intermediate compounds for preparing prasugrel

, China, , ,

合成路线：1 步

1236042-90-2

_76%

反应条件：

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ; 3 h, rt

参考文献：

New method for preparing prasugrel

, China, , ,

合成路线：1 步

150322-73-9

_73%

反应条件：

1.1 Reagents: N-Bromosuccinimide Solvents: Carbon tetrachloride ; 8 h, 76 - 78 °C; 78 °C → 30 °C
1.2 Reagents: Potassium carbonate Solvents: Acetonitrile ; 5 h, 25 - 30 °C

参考文献：

Improved process for preparing prasugrel

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Methyl isobutyl ketone ; 10 h, 40 °C

参考文献：

Process for the preparation of high-purity prasugrel

, Hungary, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 20 - 25 °C; 25 °C → 5 °C
1.2 Solvents: Acetonitrile ; 30 - 45 min, 0 - 5 °C; 5 h, 0 - 5 °C

参考文献：

An improved process for the preparation of prasugrel hydrochloride

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide , Toluene ; 25 °C → 45 °C

参考文献：

A process for the preparation of prasugrel

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 5 h, 25 - 30 °C

参考文献：

A process for the preparation of cyclopropyl(fluorophenyl)ethanone

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium bicarbonate Solvents: Acetonitrile ; rt → 15 °C; 10 - 15 °C; 2 h, 10 - 15 °C; 2 - 3 h, 10 - 15 °C

参考文献：

Process for the preparation of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

, World Intellectual Property Organization, , ,

合成路线：1 步

1100905-46-1

反应条件：

1.1 Reagents: Tetrabutylammonium bromide Solvents: Dichloromethane ; 20 h, rt → reflux

参考文献：

Process for the manufacturing of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

A method for the manufacture of highly pure prasugrel

, World Intellectual Property Organization, , ,

合成路线：1 步