95-16-9 (苯并噻唑,Benzothiazole)

124-38-9

_99%

反应条件：

1.1 Reagents: Hydrogen , Cesium fluoride Catalysts: Cobalt difluoride , Tris[2-(diphenylphosphino)ethyl]phosphine Solvents: Ethanol ; 24 h, 6 MPa, 140 °C

参考文献：

Cobalt-catalyzed synthesis of N-containing heterocycles via cyclization of ortho-substituted anilines with CO2/H2

Ke, Zhengang; Yu, Bo; Wang, Huan; Xiang, Junfeng; Han, Juanjuan; et al, Green Chemistry, 2019, 21(7), 1695-1701

合成路线：1 步

2227-79-4

_99%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Water ; 10 min, rt

参考文献：

Method for synthesizing benzothiazole by electrocatalytic benzothioamide compound in water

, China, , ,

合成路线：1 步

2227-79-4

_99%

反应条件：

1.1 Reagents: Cesium carbonate Solvents: Water ; 10 min

参考文献：

Method for synthesizing benzothiazole by microwave irradiation of benzothioamide compound in aqueous phase

, China, , ,

合成路线：1 步

68-12-2

_99%

反应条件：

1.1 Reagents: Carbon dioxide , Pentylsilane Catalysts: Tris(pentafluorophenyl)borane Solvents: Dimethylformamide ; 24 h, 0.1 MPa, 120 °C

参考文献：

Atmospheric CO2 promoted synthesis of N-containing heterocycles over B(C6F5)3 catalyst

Gao, Xiang; Yu, Bo; Mei, Qingqing; Yang, Zhenzhen; Zhao, Yanfei; et al, New Journal of Chemistry, 2016, 40(10), 8282-8287

合成路线：1 步

124-38-9

_99%

反应条件：

1.1 Reagents: Triethoxysilane Catalysts: 1-Butyl-3-methylimidazolium acetate ; rt; 24 h, 0.5 MPa, 40 °C

参考文献：

Ionic Liquid-Catalyzed C-S Bond Construction using CO2 as a C1 Building Block under Mild Conditions: A Metal-Free Route to Synthesis of Benzothiazoles

Gao, Xiang; Yu, Bo; Yang, Zhenzhen; Zhao, Yanfei; Zhang, Hongye; et al, ACS Catalysis, 2015, 5(11), 6648-6652

合成路线：1 步

149-30-4

_99%

参考文献：

Process for preparing benzothiazole

, Czechoslovakia, , ,

合成路线：1 步

103-72-0

_97%

反应条件：

1.1 Reagents: Indium trichloride Solvents: Acetonitrile ; 4 h, 80 °C

参考文献：

Production of polycarbonate high-temperature degradation-resistant agents for polycarbonate compositions

, China, , ,

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Tetrafluoroboric acid (silica-supported) ; 45 min, rt

参考文献：

Silica supported fluoroboric acid: an efficient and reusable heterogeneous catalyst for facile synthesis of 2-aliphatic benzothiazoles, benzoxazoles, benzimidazoles and imidazo[4,5-b]pyridines

Patil, Abasaheb V.; Bandgar, Babasaheb P.; Lee, Soo-Hyoung, Bulletin of the Korean Chemical Society, 2010, 31(6), 1719-1722

合成路线：1 步

615-21-4

_97%

反应条件：

1.1 Reagents: Azobenzene ; 160 - 180 °C

参考文献：

Walther reaction in the benzazoles series and preparation of their 2-deutero derivatives

Lomov, D. A.; Yutilov, Yu. M.; Smolyar, N. N., Russian Journal of Organic Chemistry, 2006, 42(2), 241-242

合成路线：1 步

136-95-8

_96%

反应条件：

1.1 Reagents: Isoamyl nitrite Solvents: Tetrahydrofuran ; 20 min, 7 bar, 120 °C

参考文献：

Flow hydrodediazoniation of aromatic heterocycles

Roeder, Liesa; Nicholls, Alexander J. ; Baxendale, Ian R., Molecules, 2019, 24(10),

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Azidotrimethylsilane Catalysts: 1H-Imidazolium, 1-methyl-3-(3-sulfopropyl)-, 1,1,1-trifluoromethanesulfonate (1:… ; 15 min, 45 - 46 °C

参考文献：

Building Heterocyclic Systems with RC(OR)2+ Carbocations in Recyclable Bronsted Acidic Ionic Liquids: Facile Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles, Benzazoles and Other Ring Systems with CH(OEt)3 and EtC(OEt)3 in [EtNH3][NO3] and [PMIM(SO3H)][OTf]

Aridoss, Gopalakrishnan; Laali, Kenneth K., European Journal of Organic Chemistry, 2011, (15), 2827-2835

合成路线：1 步

1207841-67-5

_96%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: 1,10-Phenanthroline , Cuprous iodide Solvents: 1,2-Dimethoxyethane ; 24 h, 90 °C

参考文献：

Synthesis of O-ethyl thioformate: a useful reagent for the thioformylation of amines

Borths, Christopher J.; Chan, Johann; Burke, Brenda J.; Larsen, Robert D., Synlett, 2009, (19), 3139-3142

合成路线：1 步

149-30-4

_96%

反应条件：

1.1 Reagents: Nickel dichloride Solvents: Methanol
1.2 Reagents: Hydrochloric acid Solvents: Water
1.3 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Desulfurization of organic mercaptans and disulfides.

, Germany, , ,

合成路线：1 步

1141-88-4

124-38-9

_95%

反应条件：

1.1 Reagents: (T-4)-(N,N-Diethylethanamine)trihydroboron Solvents: N-Methyl-2-pyrrolidone ; 24 h, 1 MPa, 120 °C

参考文献：

Green preparation of 1H-benzothiazole derivatives utilizing carbon dioxide

, China, , ,

合成路线：1 步

149-73-5

_95%

反应条件：

1.1 Catalysts: Sulfuric acid (polyvinylpyrrolidone-supported) , Poly(vinylpyrrolidone) (sulfuric acid-modified) ; 1 min, 60 °C

参考文献：

Application of [PVP-SO3H] HSO4 as an Efficient Polymeric-Based Solid Acid Catalyst in the Synthesis of Some Benzimidazole Derivatives

Roudsari, Fatemeh Pakpour; Seddighi, Mohadeseh; Shirini, Farhad ; Tajik, Hassan, Organic Preparations and Procedures International, 2020, 52(4), 340-353

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: N,N-Bis[3-(trimethoxysilyl)propyl]sulfamic acid (mesoporous silica-supported) ; 4 min, 80 °C

参考文献：

Periodic Mesoporous Organosilica Containing Bridged N-Sulfonic Acid Groups: Promotion of the Synthesis of N,N'-Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

Haghighat, Mahdieh; Golshekan, Mostafa; Shirini, Farhad, ChemistrySelect, 2019, 4(27), 7968-7975

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Titania (nanoporous) ; 2 min, 90 °C

参考文献：

Nanoporous TiO2 containing an ionic liquid bridge as an efficient and reusable catalyst for the synthesis of N,N'-diarylformamidines, benzoxazoles, benzothiazoles and benzimidazoles

Mazloumi, M.; Shirini, F.; Goli-Jolodar, O.; Seddighi, M., New Journal of Chemistry, 2018, 42(8), 5742-5752

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: 1798797-19-9 ; 5 min, 80 °C

参考文献：

A Novel Ionic Liquid Based on Imidazolium Cation as an Efficient and Reusable Catalyst for the One-pot Synthesis of Benzoxazoles, Benzothiazoles, Benzimidazoles and 2-Arylsubstituted Benzimidazoles

Hasanpour, Maede; Eshghi, Hossein; Bakavoli, Mehdi; Mirzaeia, Mahdi, Journal of the Chinese Chemical Society (Weinheim, 2015, 62(5), 412-419

合成路线：1 步

_95%

反应条件：

1.1 1 min, 60 °C

参考文献：

Facile synthesis of benzimidazole, benzoxazole, and benzothiazole derivatives catalyzed by sulfonated rice husk ash (RHA-SO3H) as an efficient solid acid catalyst

Shirini, Farhad; Mamaghani, Manouchehr; Seddighi, Mohadeseh, Research on Chemical Intermediates, 2015, 41(8), 5611-5619

合成路线：1 步

_95%