95-25-0 (氯唑沙宗,Chlorzoxazone)

_98%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Water ; 0 °C; 0.5 h, rt
1.2 Reagents: Potassium carbonate ; rt → 60 °C; 2 h, 60 °C

参考文献：

Process for the synthesis of chlorzoxazone

, United States, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 2-Methyltetrahydrofuran ; 1 h, reflux

参考文献：

Preparation of (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides useful as dipeptidyl peptidase I inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

57-13-6

_95%

反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Butyl acetate ; rt → reflux; 14 h, reflux

参考文献：

Preparation of chlorzoxazone

, China, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Di-2-pyridyl carbonate Solvents: Dichloromethane

参考文献：

Preparation of cyclic carbonates and 2-oxazolidones using di-2-pyridyl carbonate

Kim, Sunggak; Ko, Young Kwan, Heterocycles, 1986, 24(6), 1625-30

合成路线：1 步

2756796-87-7

_93%

反应条件：

1.1 Reagents: Potassium bicarbonate , m-Chloroperbenzoic acid Solvents: Dichloromethane ; 0.5 h, 10 - 15 °C

参考文献：

Preparation method of chlorzoxazone by ring expansion reaction

, China, , ,

合成路线：1 步

65422-72-2

_92%

反应条件：

1.1 Reagents: Sodium hydroxide , Cupric chloride , Oxygen Catalysts: Silver carbonate Solvents: Dimethyl sulfoxide , Dimethylformamide ; 120 - 125 °C

参考文献：

Preparation of chlorzoxazone

, China, , ,

合成路线：1 步

1202680-24-7

_92%

反应条件：

1.1 Solvents: Toluene ; 4 h, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 2 h, reflux

参考文献：

Facile Synthesis of Benzo[d]azol-2(3H)-ones Using 2-Phenoxycarbonyl-4,5-dichloropyridazin-3(2H)-one as Green CO Source

Ryu, Ki Eun; Kim, Bo Ram; Sung, Gi Hyeon; Yoon, Hyo Jae; Yoon, Yong-Jin, Synlett, 2015, 26(14), 1985-1990

合成路线：1 步

503-38-8

_92%

反应条件：

1.1 Solvents: Toluene ; rt → 110 °C; 0.5 h, 110 °C; 0.5 h, 110 °C

参考文献：

Synthesis of chlorzoxazone by the method of diphosgene

Li, Yong-shu; Wu, Chun-lei; Su, Wei-ke, Gaoxiao Huaxue Gongcheng Xuebao, 2006, 20(2), 254-257

合成路线：1 步

_92%

反应条件：

1.1 Reagents: S,S-Bis(1-phenyl-1H-tetrazol-5-yl) carbonodithioate Solvents: Acetonitrile

参考文献：

Studies on activating methods of functional groups. Part XVII. Novel reactions of S,S'-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate

Takeda, Kazuyoshi; Tsuboyama, Kanoko; Takayanagi, Hiroaki; Shirokami, Rie; Takeura, Masumi; et al, Chemical & Pharmaceutical Bulletin, 1989, 37(9), 2334-7

合成路线：1 步

57-13-6

_92%

参考文献：

Preparation of certain derivatives of benzoxazole

Nagano, Toyoyuki; Itoh, Motoko; Matsumura, Konomu, Journal of the American Chemical Society, 1953, 75, 2770-1

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 2 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Comparative evaluation of 99mTc-MBIP-X/11[C] MBMP for visualization of 18 kDa translocator protein

Srivastava, Pooja; Kumari, Neelam; Kakkar, Dipti; Kaul, Ankur; Kumar, Pravir; et al, New Journal of Chemistry, 2019, 43(28), 11288-11295

合成路线：1 步

57-13-6

_91%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; < 10 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 2 h, pH 7, 10 °C → reflux; cooled
1.3 Reagents: Water ; 1 h, reflux

参考文献：

Synthesis and characterization of benzoxazolone derivatives

Feng, Lei; Zhang, Tianchang; Ju, Xiulian, Wuhan Gongcheng Daxue Xuebao, 2011, 33(5), 12-14

合成路线：1 步

2169399-05-5

_90%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Dimethylformamide ; rt; 1.5 h, 90 °C; 90 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group

Yuan, Ye; Guo, Dou; Liu, Yibo; Wan, Congcong; Lu, Dongbiao; et al, European Journal of Organic Chemistry, 2022, 2022(17),

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dichloromethane ; 2 - 3 h, rt
1.2 Solvents: Water ; 1 h, rt

参考文献：

Novel process for the preparation of suvorexant and intermediates thereof

, India, , ,

合成路线：1 步

32315-10-9

_89%

反应条件：

1.1 Reagents: Triethylamine Solvents: Chloroform , Toluene ; 0 °C; 1 h, 0 °C; 0 °C → 110 °C; 7 h, 110 °C

参考文献：

Synthesis and bioactivity of substituted 3H-benzoxazol-2-ones and 4H-benzoxazin-3-ones

Yuan, Li-ping; Cao, Jin; Chen, Liang; Shen, Zhou; Ni, Chang-chun; et al, Xiandai Nongyao, 2009, 8(1), 15-19

合成路线：1 步

32315-10-9

_89%

反应条件：

1.1 Reagents: Triethylamine Solvents: Chloroform , Toluene ; rt → 0 °C; 1 h, 0 °C; 0 °C → 110 °C; 7 h, 110 °C; 110 °C → rt

参考文献：

Synthesis and bioactivity of substituted 2(3H)-benzoxazolone derivatives

Wu, Yue; Yuan, Liping; Guo, Qingming; Zhang, Yibin, Nongyaoxue Xuebao, 2005, 7(4), 306-310

合成路线：1 步

3582-05-6

_88%

反应条件：

1.1 Solvents: Acetonitrile ; 1 h, rt
1.2 Reagents: Water ; rt

参考文献：

Concise and Additive-Free Click Reactions between Amines and CF3SO3CF3

Song, Hai-Xia; Han, Zhou-Zhou; Zhang, Cheng-Pan, Chemistry - A European Journal, 2019, 25(46), 10907-10912

合成路线：1 步

_88%

反应条件：

1.1 Solvents: Dimethylformamide ; 5 h, rt → 80 °C

参考文献：

Application of Silicon-Initiated Water Splitting for the Reduction of Organic Substrates

Gevorgyan, Ashot; Mkrtchyan, Satenik; Grigoryan, Tatevik; Iaroshenko, Viktor O., ChemPlusChem, 2018, 83(5), 375-382

合成路线：1 步

_87%

反应条件：

1.1 Solvents: Dimethylformamide ; 5 h, 80 °C; 80 °C → rt
1.2 Reagents: Water ; rt

参考文献：

Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches

Zou, Yi ; Wang, Yan; Wang, Fang; Luo, Minghao; Li, Yuezhen; et al, European Journal of Medicinal Chemistry, 2017, 138, 199-211

合成路线：1 步

_87%