95-53-4 (邻甲苯胺,toluidine)

反应条件：

1.1 Reagents: Formic acid (polymer-supported) , Zinc Solvents: Methanol ; 20 min, rt

参考文献：

Clean and efficient hydrogenative cleavage of azo compounds using polymer-supported formate and zinc

Srinivasa, G. R.; Abiraj, K.; Gowda, D. Channe, Synthetic Communications, 2005, 35(9), 1161-1165

合成路线：1 步

反应条件：

1.1 Reagents: Zinc , Ammonium chloride Solvents: Methanol ; 15 min, rt

参考文献：

Reductive cleavage of azo compounds by zinc and ammonium chloride

Sridhara, M. B.; Srinivasa, G. R.; Gowda, D. Channe, Synthetic Communications, 2004, 34(8), 1441-1446

合成路线：1 步

反应条件：

1.1 Reagents: Triethylammonium formate Catalysts: Zinc Solvents: Methanol ; 5 min, rt

参考文献：

Zinc-Catalyzed Hydrogenative Cleavage of Azo Compounds Using Triethylammonium Formate

Srinivasa, G. R.; Abiraj, K.; Gowda, D. Channe, Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 2004, 34(2), 223-231

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium acetate Catalysts: Zinc Solvents: Methanol ; 5 min, rt

参考文献：

Hydrogenative cleavage of azo compounds catalyzed by commercial zinc dust using ammonium acetate

Srinivasa, G. R.; Abiraj, K.; Gowda, D. Channe, Indian Journal of Chemistry, 2004, (1), 192-195

合成路线：1 步

反应条件：

1.1 Reagents: Formic acid , Hydrazine ; 0 °C
1.2 Catalysts: Nickel Solvents: Methanol ; 12 h, reflux

参考文献：

Facile transfer hydrogenation of azo compounds to hydrazo compounds and anilines by using Raney Nickel and hydrazinium monoformate

Prasad, H. S.; Gowda, Shankare; Gowda, D. Channe, Synthetic Communications, 2004, 34(1), 1-10

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium formate , Nickel Solvents: Methanol ; 12 min, rt

参考文献：

Rapid cleavage of azo compounds to amine/s using Raney nickel and ammonium formate or formic acid

Gowda, D. Channe; Gowda, Shankare; Abiraj, K., Indian Journal of Chemistry, 2003, (7), 1774-1776

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium formate , Magnesium Solvents: Methanol ; rt; 15 min, rt

参考文献：

Magnesium-catalyzed cost effective and rapid reductive cleavage of azo compounds using ammonium formate

Abiraj, K.; Gowda, Shankare; Gowda, D. Channe, Journal of Chemical Research, 2003, (5), 299-300

合成路线：1 步

反应条件：

1.1 Reagents: Formic acid, compd. with hydrazine (1:1) Catalysts: Zinc Solvents: Methanol ; 12 min, reflux

参考文献：

Reductive cleavage of azo compounds catalyzed by commercial zinc dust and hydrazinium monoformate as a new hydrogen donor for heterogeneous catalytic transfer hydrogenation

Gowda, Shankare; Abiraj, K.; Gowda, D. Channe, Journal of Chemical Research, 2002, (8), 384-385

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium formate Catalysts: Zinc Solvents: Methanol

参考文献：

Reductive cleavage of azo compounds catalyzed by commercial zinc dust using ammonium formate or formic acid

Gowda, Shankare; Abiraj, K.; Gowda, D. Channe, Tetrahedron Letters, 2002, 43(7), 1329-1331

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ; 3 h, 1 atm, 30 °C

参考文献：

Tuning the Surface Wettability of Pd/COFs for Selective Hydrogenation

Li, Xiang; Li, He; Li, Chunzhi; Wang, Maodi; Yang, Qihua, ChemCatChem, 2023, 15(12),

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Cobalt Solvents: Methanol ; 1 MPa, rt → 110 °C; 4 h, 110 °C

参考文献：

Chemoselective Hydrogenation of Nitroarenes by an Efficient Co@NC/AC Catalyst

Zhang, Guanyi; Liu, Lin; Zhu, Qingqing; Kong, Xiangjin, Catalysis Letters, 2023, 153(5), 1536-1542

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Iridium (H 102-supported) Solvents: Methanol ; 30 min, 25 °C

参考文献：

Highly selective reduction catalyst for nitroarenes and preparation method and application thereof

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Iron , Iron carbide (Fe3C) Solvents: Ethanol ; 2 h, 60 °C

参考文献：

MOF-derived N-doped carbon composites embedded with Fe/Fe3C nanoparticles as highly chemoselective and stable catalysts for catalytic transfer hydrogenation of nitroarenes

Feng, Binbin; Xu, Qionghao; Wu, Xiaoxue; Ye, Chunlin; Fu, Yanghe; et al, Applied Surface Science, 2021, 557,

合成路线：1 步

611-21-2

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: (OC-6-14)-[[2,3-Butanedione 2,3-di(oximato-κN)](1-)][2,3-butanedione 2,3-di(oxim… , Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[2-(2-pyri… Solvents: Acetonitrile ; rt → -78 °C; 24 h, -78 °C

参考文献：

Minimization of Back-Electron Transfer Enables the Elusive sp3 C-H Functionalization of Secondary Anilines

Zhao, Huaibo; Leonori, Daniele, Angewandte Chemie, 2021, 60(14), 7669-7674

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Iron oxide (Fe2O3) (N-doped porous organic polymers) Solvents: Ethanol ; 110 min, 80 °C

参考文献：

Iron oxide modified N-doped porous carbon derived from porous organic polymers as a highly-efficient catalyst for reduction of nitroarenes

Lv, Jing; Liu, Zhengtang; Dong, Zhengping, Molecular Catalysis, 2020, 498,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen , Aminoborane Catalysts: Nickel , Copper Solvents: Methanol , Water ; 30 min, rt

参考文献：

Preparation method of supported Cu-Ni bimetallic catalyst and its application in reduction reaction

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Cobalt (nitrogen-doped carbon encapsulated) Solvents: Ethanol ; 60 min, 80 °C

参考文献：

Selective hydrogenation of nitroarenes under mild conditions by the optimization of active sites in a well defined Co@NC catalyst

Chen, Shuo; Ling, Li-Li; Jiang, Shun-Feng; Jiang, Hong, Green Chemistry, 2020, 22(17), 5730-5741

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Ammonium formate Catalysts: Cobalt (N, S co-doped carbon-encapsulated) Solvents: Tetrahydrofuran , Water ; 4 h, 120 °C

参考文献：

Selective Transfer Hydrogenation and N-Formylation of Nitroarenes by a Facilely Prepared N, S Co-doped Carbon-Encapsulated Cobalt Nanoparticle Catalyst

Zhu, Qian; Sun, Xun; Zhao, Hong; Xu, Dan; Dong, Zhengping, Industrial & Engineering Chemistry Research, 2020, 59(13), 5615-5623

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Niobium pentoxide , Palladium Solvents: Methanol-d4 , Water ; 1.5 h, rt

参考文献：

Facile Hydrogenative Deprotection of N-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon

Yamamoto, Yuta; Shimizu, Eisho; Ban, Kazuho; Wada, Yoshiyuki; Mizusaki, Tomoteru; et al, ACS Omega, 2020, 5(6), 2699-2709

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Ammonia borane Catalysts: Alumina , Cobalt alloy, base, Co 67,Ni 33 Solvents: Methanol , Water ; 10 min, 323 K

参考文献：

Superfine CoNi alloy embedded in Al2O3 nanosheets for efficient tandem catalytic reduction of nitroaromatic compounds by ammonia borane

Cheng, Sihang; Liu, Yanchun; Zhao, Yingnan; Zhao, Xinyu; Lang, Zhongling; et al, Dalton Transactions, 2019, 48(47), 17499-17506

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Platinum Solvents: Water ; 2000 h, 0.8 MPa, 80 °C

参考文献：

Preparation of nitrogen-modified carbon-supported noble metal hydrogenation catalyst and application thereof in hydrogenation reaction of nitrobenzene compounds

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Nickel ; 3 h, 1.5 MPa, 180 °C; 1.5 MPa, 180 °C → 190 °C; 30 min, 1.5 MPa, 190 °C

参考文献：

Preparation method of methylaniline by hydrogenation of nitrotoluene

, China, , ,

合成路线：1 步

314283-02-8

_100%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Xylene ; 3 h, 120 °C

参考文献：

2-Methoxyphenyl isocyanate: a chemoselective multitasking reagent for an amine protection/deprotection sequence

Velappan, Anand Babu; Kogatam, Subhashini; Datta, Dhrubajyoti; Srithar, Rakshantha; Nanjappan, Gunasekaran; et al, Organic Chemistry Frontiers, 2019, 6(14), 2360-2364

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Carbon Solvents: Ethanol ; 80 °C
1.2 Reagents: Hydrazine hydrate (1:1) ; 12 h, 80 °C

参考文献：

Renewable Soybean Pulp Derived N-Doped Carbon Materials for Efficient Chemoselective Hydrogenation of Halogenated Nitrobenzenes

Lv, Jing; Zheng, Yunfeng; Zhu, Yangyang; Yuan, Man; Chang, Yanlong; et al, ChemistrySelect, 2019, 4(14), 4083-4091

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 8 min, 0.2 MPa, 50 °C

参考文献：

Pd-Pt/modified GO as an efficient and selective heterogeneous catalyst for the reduction of nitroaromatic compounds to amino aromatic compounds by the hydrogen source

Salahshournia, Hossein; Ghiaci, Mehran, Applied Organometallic Chemistry, 2019, 33(4),

合成路线：1 步

31656-92-5

_100%

反应条件：

1.1 Reagents: Sodium formate , Potassium hydroxide ; 1 h

参考文献：

Highly efficient nitrobenzene and alkyl/aryl azide reduction in stainless steel jars without catalyst addition

Martina, Katia; Baricco, Francesca; Tagliapietra, Silvia; Moran, Maria Jesus; Cravotto, Giancarlo; et al, New Journal of Chemistry, 2018, 42(23), 18881-18888

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Ammonium formate Catalysts: Cobalt Solvents: Tetrahydrofuran , Water ; 12 h, 120 °C

参考文献：

Method for preparing aromatic amine compound

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Dimethylformamide ; 6 h, 0.6 MPa, 120 °C

参考文献：

Solvent-Driven Selectivity Control to Either Anilines or Dicyclohexylamines in Hydrogenation of Nitroarenes over a Bifunctional Pd/MIL-101 Catalyst

Chen, Xiaodong; Shen, Kui ; Ding, Danni; Chen, Junying; Fan, Ting ; et al, ACS Catalysis, 2018, 8(11), 10641-10648

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Nickel , [μ-[2,2′-[(1S,2S)-1,2-Cyclohexanediylbis[[(E)-nitrilo]methylidyne]]bis[4-methylp… Solvents: Ethanol ; 7.5 h, 2.2 MPa, 210 °C

参考文献：

High Catalytic Performance of a CeO2-Supported Ni Catalyst for Hydrogenation of Nitroarenes, Fabricated via Coordination-Assisted Strategy

She, Wei; Qi, Tianqinji; Cui, Mengxing; Yan, Pengfei; Ng, Seik Weng; et al, ACS Applied Materials & Interfaces, 2018, 10(17), 14698-14707

合成路线：1 步

83-42-1

87-60-5

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium (nanoclusters, nitrogen-doped mesoporous carbon-supported) ; 3 h, 1 MPa, rt → 45 °C

参考文献：

Solvent-Free Selective Hydrogenation of Nitroarenes Using Nanoclusters of Palladium Supported on Nitrogen-Doped Ordered Mesoporous Carbon

Huang, Haigen; et al, ChemCatChem, 2016, 8(8), 1485-1489

合成路线：1 步

83-42-1