955887-09-9 (4-溴-2,6-二氟苯甲酸叔丁酯,Tert-butyl 4-bromo-2,6-difluorobenzoate)

_84%

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C; 15 min, -78 °C; 30 min, -78 °C
1.2 Solvents: Tetrahydrofuran ; 1 h, -78 °C
1.3 2 h, -78 °C → rt

参考文献：

Di-tert-butyl dicarbonate: a versatile carboxylating reagent

Augustine, John Kallikat; Arthoba Naik, Y.; Vairaperumal, Veeramani; Narasimhan, Sharmila, Tetrahedron, 2009, 65(1), 134-138

合成路线：1 步

1860-21-5

_77%

反应条件：

1.1 Catalysts: Boron trifluoride etherate Solvents: Dichloromethane , Cyclohexane ; 16 h, rt; cooled
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 10 min, cooled

参考文献：

Preparation of 3-hydroxyimidazolidin-4-one compounds as inhibitors of indoleamine 2,3-dioxygenase

, World Intellectual Property Organization, , ,

合成路线：1 步

81464-59-7

_77%

反应条件：

1.1 Catalysts: Boron trifluoride etherate Solvents: Dichloromethane , Cyclohexane ; 16 h, rt; rt → 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 10 min, 0 °C

参考文献：

Imidazolidine derivatives as inhibitors of indoleamine 2,3-dioxygenase and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

_72%

反应条件：

1.1 Reagents: Di-tert-butyl dicarbonate Catalysts: 4-(Dimethylamino)pyridine Solvents: tert-Butanol ; 16 h, 40 °C

参考文献：

Preparation of N-(4-sulfonamidobenzoyl)-L-phenylalanine and N-(4-sulfonamidobenzoyl)-3-(pyridin-2-yl)-L-alanine derivatives as α4-integrin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine , Di-tert-butyl dicarbonate Solvents: Dichloromethane ; 12 h, rt

参考文献：

N-Benzoyl-2-aminopropanoic acid derivatives as α4β7 integrin inhibitors and their preparation, pharmaceutical compositions and use in the treatment of inflammatory disease

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: tert-Butanol , Tetrahydrofuran ; 18 h, rt
1.2 Reagents: Imidazole ; 1 h, rt

参考文献：

Novel compounds and pharmaceutical compositions thereof for the treatment of diseases and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 12 h, rt

参考文献：

Preparation of substituted benzodioxanes and related compounds for inhibition of α4β7 integrin

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 12 h, rt

参考文献：

Preparation of quinoline derivatives as α4β7 integrin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

75-65-0

反应条件：

1.1 Reagents: Di-tert-butyl dicarbonate Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane , tert-Butanol ; 12 h, rt

参考文献：

Preparation of imidazopyridine derivatives as α4β7 integrin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: tert-Butanol ; overnight, 40 °C

参考文献：

Preparation of tertiary amines and (thio)amides as liver X receptor modulators for treatment of fatty liver disease and other disorders

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: tert-Butanol ; overnight, 40 °C

参考文献：

Sulfonamide-, sulfinamide- or sulfonimidamide and derivatives as liver X receptor (LXR) modulators and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

461-96-1

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran , Hexane ; -78 °C; 1 h, -78 °C
1.2 2 h, -78 °C → rt

参考文献：

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

, European Patent Organization, , ,

合成路线：1 步