95603-44-4 (7,10-二(2,2,2-三氯乙氧羰基)-10-脱乙酰基巴卡丁 III,7,10-Di-O-trichloroethoxycarbonyl-10-deacetyl Baccatin III)

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 1 h, 0 °C; 1 h, 0 °C; > 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Method for preparing cabazitaxel from 10-deacetylbaccatin III

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Pyridine Solvents: Dichloromethane ; 2 h, 2 °C

参考文献：

Preparation of cabazitaxel from 10-deacetylbaccatin

, China, , ,

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Chloroform , Pyridine ; 100 s, 10 bar, 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Method for preparing 7,10-bis(trichloromethoxy formyl chloride)-10-deacetylate baccatin III using microchannel reactor

, China, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Pyridine , Sodium bicarbonate Solvents: Dichloromethane
1.2 rt; 3 h, rt
1.3 Reagents: Water ; 0.5 h, rt

参考文献：

Industrial process for semisynthesis of Docetaxel

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; -10 °C; -10 °C → rt; 2.2 h, rt

参考文献：

Preparation of 10-deacetyl paclitaxel

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; -5 - 0 °C; 1 h, -5 - 0 °C; 0 °C → rt; 4 h, rt

参考文献：

Synthesis of daxotere

Li, Peng; Li, Chunxiang; Li, Xiang, Zhongguo Yaowu Huaxue Zazhi, 2009, 19(5), 356-360

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; -5 - 0 °C; 1 h, -5 - 0 °C; 0 °C → rt; 4 h, rt

参考文献：

Synthesis of docetaxel

Li, Peng; Li, Chunxiang, Zhongguo Yiyao Gongye Zazhi, 2009, 40(2), 90-92

合成路线：1 步

_94%

反应条件：

1.1 Solvents: Pyridine ; 10 - 15 °C; 10 - 20 min, 10 - 15 °C; 10 min, 15 ± 5 °C
1.2 Reagents: Water

参考文献：

Method for preparation of Docetaxel from 10-deacetylbaccatin III

, China, , ,

合成路线：1 步

_93%

反应条件：

1.1 Solvents: Dichloromethane , Pyridine ; 0 - 5 °C; 30 min, 0 - 10 °C
1.2 Reagents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized

参考文献：

Preparation of 10-acetyldocetaxel

, China, , ,

合成路线：1 步

_92%

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C; 5 h, 0 °C

参考文献：

Method for synthesis of Paclitaxel and Docetaxel

, China, , ,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Pyridine ; 30 min, rt

参考文献：

Design, synthesis and cytotoxicity of novel 3'-N-alkoxycarbonyl docetaxel analogs

Chang, Jun; Hao, Xiao-Dong; Hao, Yun-Peng; Lu, Hong-Fu; Yu, Jian-Ming; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(24), 6834-6837

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; < 0 °C; 35 min, 0 °C
1.2 Reagents: Water

参考文献：

Regio- and stereoselective methods for the conversion of (2S,3R)-β-phenylglycidic acid esters to taxoids and other enantiopure (2R,3S)-phenylisoserine esters

Afon'kin, A. A.; Kostrikin, L. M.; Shumeiko, A. E.; Popov, A. F.; Matveev, A. A.; et al, Russian Chemical Bulletin, 2012, 61(11), 2149-2162

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Dichloromethane , Pyridine ; 10 min, 0 °C; 30 min, 0 °C; 0 °C → rt; 30 min, rt
1.2 Reagents: Water

参考文献：

Method for synthesis of Cabazitaxel from 10-deacetylbaccatin III

, China, , ,

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Pyridine ; cooled; 0.5 h, 0 °C → rt
1.2 Reagents: Water ; rt

参考文献：

Method for synthesis of taxane derivatives and their medicinal application

, China, , ,

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Pyridine ; 1 h, 15 - 17 °C; 30 min, 40 - 45 °C
1.2 Reagents: Water ; 10 min; 30 min

参考文献：

Study on the industrial process for docetaxel synthesis

Shi, Li-bei; Zhang, Li-chun; Niu, Hai-bin; Feng, Jun-jie, Shanghai Yiyao, 2012, 33(13), 41-43

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Dichloromethane , Pyridine ; 45 - 60 min, 25 - 28 °C; 5 - 10 min, 25 - 30 °C
1.2 Reagents: Water

参考文献：

Alternative Synthesis and the Determination of Absolute Configuration of Docetaxel, an Anticancer Drug

Sekhar, N. M.; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli, Synthetic Communications, 2012, 42(23), 3482-3492

合成路线：1 步

_90%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine Solvents: 1,4-Dioxane ; 2 h, 80 °C

参考文献：

A convenient and easy-controlled method for preparation of 7,10-bis(2,2,2-trichloroethyloxycarbonyl)-10-deacetyl baccatin III

Xin, Qi; Li, Xu; Xiao-ju, Lin; Yong, Ji; Tian-wei, Wang, Chemical Research in Chinese Universities, 2004, 20(6), 813-816

合成路线：1 步

_88%

反应条件：

1.1 Solvents: Pyridine ; 15 min, rt
1.2 Solvents: Dichloromethane ; 1 h, rt; 5 min, rt
1.3 Solvents: Water ; 5 min, rt

参考文献：

Processes for preparing docetaxel crystalline polymorphs

, World Intellectual Property Organization, , ,

合成路线：1 步

_87%

反应条件：

1.1 Solvents: Pyridine ; rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized, rt

参考文献：

Process for preparation of docetaxel side chain 2'-derived novel taxanes anti-tumor compound

, China, , ,

合成路线：1 步

_87%