95-80-7 (2,4-二氨基甲苯,4-Methylbenzene-1,3-diamine)

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 15 min, 0.2 MPa, 50 °C

参考文献：

Pd-Pt/modified GO as an efficient and selective heterogeneous catalyst for the reduction of nitroaromatic compounds to amino aromatic compounds by the hydrogen source

Salahshournia, Hossein; Ghiaci, Mehran, Applied Organometallic Chemistry, 2019, 33(4),

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Ruthenium , Sodium nitrite Solvents: Isopropanol ; 0 MPa → 4 MPa; 4 h, 4 MPa → 8.3 MPa, rt → 110 °C

参考文献：

One pot catalytic NO2 reduction, ring hydrogenation, and N-alkylation from nitroarenes to generate alicyclic amines using Ru/C-NaNO2

Oh, Seung Geun; Mishra, Vivek; Cho, Jin Ku; Kim, Baek-Jin; Kim, Hoon Sik; et al, Catalysis Communications, 2014, 43, 79-83

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Sodium acetate , Palladium (polymer-supported) , Platinum (polymer-supported) Solvents: Ethanol , Water

参考文献：

Hydrogenation of nitroaromatics by polymer-anchored bimetallic palladium-ruthenium and palladium-platinum catalysts under mild conditions

Yu, Zhengkun; Liao, Shijian; Xu, Yun; Yang, Bin; Yu, Daorong, Journal of Molecular Catalysis A: Chemical, 1997, 120(1-3), 247-255

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Carbon monoxide , Iron oxide (Fe2O3) , Alumina , Hydrogen sulfide

参考文献：

Catalytic reduction of dinitroaromatic compounds with hydrogen sulfide-carbon monoxide. A novel, low-cost replacement for elemental hydrogen

Ratcliffe, Charles T.; Pap, Geza, Journal of the Chemical Society, 1980, (6), 260-1

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium borohydride Catalysts: 1620063-85-5 Solvents: Water ; 1 h, 60 °C

参考文献：

Copper(II) complex with oxazoline ligand: Synthesis, structures and catalytic activity for nitro compounds reduction

Jia, Wei-Guo; Li, Mei; Zhi, Xue-Ting; Gao, Li-Li; Du, Jun, Journal of Molecular Structure, 2020, 1217,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Ammonia borane Catalysts: Hexadecyltrimethylammonium bromide , Ruthenium(2+), [(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][1,1′-(2,6-pyr… Solvents: Acetonitrile , Water ; 8 h, 353 K

参考文献：

Synthesis, characterization, and catalytic activity of half-sandwich ruthenium complexes with pyridine/phenylene bridged NHC = E (NHC = N-heterocyclic carbene, E = S, Se) ligands

Jia, Wei-Guo ; Du, Teng-Teng; Gao, Li-Li; Du, Jun, Applied Organometallic Chemistry, 2020, 34(7),

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Carbon , Cobalt sulfide (CoS2) Solvents: Methanol ; 6 h, 3 MPa, 110 °C

参考文献：

The synergic effects at the molecular level in CoS2 for selective hydrogenation of nitroarenes

Wei, Zhongzhe; Mao, Shanjun; Sun, Fanfei; Wang, Jing; Mei, Bingbao; et al, Green Chemistry, 2018, 20(3), 671-679

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Copper lanthanum silicide (Cu0.67LaSi1.33) Solvents: Isopropanol ; 30 h, 3 MPa, 120 °C

参考文献：

Copper-Based Intermetallic Electride Catalyst for Chemoselective Hydrogenation Reactions

Ye, Tian-Nan ; Lu, Yangfan ; Li, Jiang; Nakao, Takuya; Yang, Hongsheng; et al, Journal of the American Chemical Society, 2017, 139(47), 17089-17097

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium (nanoclusters, nitrogen-doped mesoporous carbon-supported) ; 2 h, 1 MPa, rt → 120 °C

参考文献：

Solvent-Free Selective Hydrogenation of Nitroarenes Using Nanoclusters of Palladium Supported on Nitrogen-Doped Ordered Mesoporous Carbon

Huang, Haigen; Wang, Xueguang; Tan, Mingwu; Chen, Chenju; Zou, Xiujing; et al, ChemCatChem, 2016, 8(8), 1485-1489

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Cobalt (complex with N-doped graphene) , Graphene (complex with cobalt, N-doped) Solvents: Ethanol ; 3 MPa, 120 °C; 10 h, 3 MPa, 110 °C

参考文献：

In Situ-Generated Co0-Co3O4/N-Doped Carbon Nanotubes Hybrids as Efficient and Chemoselective Catalysts for Hydrogenation of Nitroarenes

Wei, Zhongzhe; Wang, Jing; Mao, Shanjun; Su, Diefeng; Jin, Haiyan; et al, ACS Catalysis, 2015, 5(8), 4783-4789

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Formic acid Catalysts: Palladium , Carbon nitride (C3N4) Solvents: Water ; 5 min, 25 °C

参考文献：

Photochemically Engineering the Metal-Semiconductor Interface for Room-Temperature Transfer Hydrogenation of Nitroarenes with Formic Acid

Li, Xin-Hao; Cai, Yi-Yu; Gong, Ling-Hong; Fu, Wei; Wang, Kai-Xue; et al, Chemistry - A European Journal, 2014, 20(50), 16732-16737

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Formic acid , Triethylamine Catalysts: Molybdenum(1+), tris[1,1′-(1,2-ethanediyl)bis[1,1-dimethylphosphine-κP]]trihydro… Solvents: Tetrahydrofuran ; 18 h, 70 °C

参考文献：

Chemoselective Transfer Hydrogenation to Nitroarenes Mediated by Cubane-Type Mo3S4 Cluster Catalysts

Sorribes, Ivan; Wienhoefer, Gerrit; Vicent, Cristian; Junge, Kathrin; Llusar, Rosa; et al, Angewandte Chemie, 2012, 51(31), 7794-7798

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium , Titania (sulfated) Solvents: Isopropanol ; 65 °C

参考文献：

Porous catalysts for liquid phase hydrogenation with molecular hydrogen

, Russian Federation, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Rhodium trichloride , Tetrachloropalladic acid , Cerium trichloride heptahydrate Solvents: Water ; pH 10, rt; rt → 80 °C; pH 6.4
1.2 Reagents: Formaldehyde
1.3 Reagents: Hydrogen Solvents: Water ; 10 bar; rt → 120 °C

参考文献：

Supported trimetallic catalyst for hydrogenation of nitroaromatic compounds

, World Intellectual Property Organization, , ,

合成路线：1 步

610-39-9

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Tungsten carbide (WC) Solvents: Water

参考文献：

Tungsten carbide as catalyst for the hydrogenation of nitro or nitroso aromatic compounds to aromatic amines

, European Patent Organization, , ,

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Cobalt diacetate , 1,2-Acenaphthylenedione, 1,2-bis(2-phenylhydrazone) Solvents: Ethanol , Tetrahydrofuran ; rt; 2 h, 60 °C
1.2 Catalysts: Graphene ; 30 min, rt; 18 h, 25 °C; rt → 800 °C; 2 h, 800 °C
1.3 Reagents: Hydrogen Solvents: Ethanol , Water ; 20 h, 20 bar → 50 bar, 110 °C

参考文献：

Co-based heterogeneous catalysts from well-defined α-diimine complexes: Discussing the role of nitrogen

Formenti, Dario; Ferretti, Francesco; Topf, Christoph; Surkus, Annette-Enrica; Pohl, Marga-Martina; et al, Journal of Catalysis, 2017, 351, 79-89

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Sodium borohydride Catalysts: Palladium, bis[2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl 3-(oxo-κO)butanoato-κO… Solvents: Water ; 5 h, rt

参考文献：

Polymer supported palladium nanocrystals as efficient and recyclable catalyst for the reduction of nitroarenes to anilines under mild conditions in water

Dell'Anna, Maria Michela; Intini, Simona; Romanazzi, Giuseppe; Rizzuti, Antonino; Leonelli, Cristina; et al, Journal of Molecular Catalysis A: Chemical, 2014, 395, 307-314

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrogen Catalysts: 1,10-Phenanthroline , Ferrous acetate Solvents: Tetrahydrofuran , Water ; 16 h, 50 bar, 120 °C

参考文献：

Nanoscale Fe2O3-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines

Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; et al, Science (Washington, 2013, 342(6162), 1073-1076

合成路线：1 步

71785-48-3

_97%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Palladium (on carbon) Solvents: Methanol ; 15 min, 120 °C

参考文献：

Selective reduction of halogenated nitroarenes with hydrazine hydrate in the presence of Pd/C

Li, Fang; Frett, Brendan; Li, Hong-Yu, Synlett, 2014, 25(10), 1403-1408

合成路线：1 步

_97%