96034-64-9 (美罗培南侧链,Side chain for meropenem)

_100%

反应条件：

1.1 Catalysts: Potassium hydroxide Solvents: Ethyl acetate , Water ; 25 °C
1.2 Reagents: Acetic acid Solvents: Water ; pH 7.0

参考文献：

Method for green preparation of purification meropenem side chain

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium hydroxide

参考文献：

Some improvements in total synthesis of meropenem

Hu, Lai-Xing; Liu, Jun; Jin, Jie, Zhongguo Yiyao Gongye Zazhi, 2000, 31(7), 290-292

合成路线：1 步

151072-00-3

124-40-3

_98%

反应条件：

1.1 Solvents: Tetrahydrofuran , Water ; 1 h, cooled

参考文献：

Improved process for producing intermediate for side chain of carbapenem

, World Intellectual Property Organization, , ,

合成路线：1 步

2178095-34-4

124-40-3

_97%

反应条件：

1.1 Reagents: Isopropyl chloroformate , Triethylamine , Methanesulfonyl chloride , Tributylphosphine , Sodium chloride , Sodium hydrosulfide Solvents: Dichloromethane , Water ; 0 - 3 °C

参考文献：

Continuous production method for meropenem side chain from O powder and activator and device

, China, , ,

合成路线：1 步

2178095-34-4

_96%

反应条件：

1.1 Reagents: Ethylenediaminetetraacetic acid , Disodium sulfide , Magnesium chloride , Polyoxyethylene sorbitan monooleate , Sorbitan (ester) Catalysts: Serine O-acetyltransferase , Acetylserine sulfhydrylase Solvents: Water ; pH 7, 35 °C

参考文献：

Bioconversion method of penem pharmaceutical intermediate

, China, , ,

合成路线：1 步

127966-47-6

_92%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dimethylformamide ; 10 min, 0 - 5 °C
1.2 3 h, 0 - 5 °C
1.3 Reagents: Water

参考文献：

Penem pharmaceutical intermediate and preparation method thereof

, China, , ,

合成路线：1 步

127966-47-6

_90%

反应条件：

1.1 Reagents: Diisopropylethylamine ; 3 h, 0 - 5 °C

参考文献：

Process for preparation of penem pharmaceutical thiol side chain

, China, , ,

合成路线：1 步

936226-36-7

_90%

反应条件：

1.1 Reagents: Tributylphosphine Solvents: Tetrahydrofuran , Water ; 30 min, rt

参考文献：

Method for synthesis of Meropenem

, China, , ,

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 0 - 5 °C; 15 min, 0 - 15 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 10
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Synthesis of meropenem trihydrate

Zhao, Yanfang; Hao, Jinheng; Li, Juan; Liu, Yajing; Yang, Youbin; et al, Zhongguo Yaowu Huaxue Zazhi, 2005, 15(2), 97-99

合成路线：1 步

151072-00-3

_87%

反应条件：

1.1 Solvents: Acetone ; rt → 10 °C
1.2 Reagents: Triethylamine ; 15 - 20 °C; 30 min, 15 - 20 °C

参考文献：

Method for preparation of bicyclic intermediate and application for preparation penem-like side chain

, World Intellectual Property Organization, , ,

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Acetyl chloride Solvents: Methanol ; 5 h, 25 °C

参考文献：

A process for the preparation of carbapenem compounds

, World Intellectual Property Organization, , ,

合成路线：1 步

_80%

反应条件：

1.1 Catalysts: Acetyl chloride Solvents: Methanol ; 6 h, rt

参考文献：

Deacetylation of thioacetate using acetyl chloride in methanol

Tewari, Neera; Nizar, Hashim; Mane, Avinash; George, Vinod; Prasad, Mohan, Synthetic Communications, 2006, 36(13), 1911-1914

合成路线：1 步

130625-69-3

507-09-5

_67%

反应条件：

1.1 Reagents: Triphenylphosphine , Diethyl azodicarboxylate Solvents: Tetrahydrofuran ; 0.5 h, 0 °C; 1 h, 0 °C
1.2 0.5 h, 0 °C; 1 h, 0 °C; 2 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 0.5 h, cooled; 0.5 h, cooled
1.4 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

New synthesis method of sidechain of meropenem

Lin, Qi-si; Mou, Jie; Zhang, Ling, Guangzhou Huagong, 2013, 41(22), 47-48

合成路线：1 步

130625-70-6

_61%