96088-62-9 (丙炔酸异丙酯,propan-2-yl prop-2-ynoate)

_90%

反应条件：

1.1 Reagents: Boron trifluoride etherate Solvents: Isopropanol ; 30 min, 25 °C; 3 h, 25 °C → 90 °C
1.2 Reagents: Water ; 30 min, 90 °C → rt

参考文献：

Preparation of phenyltriazolylpropanoic acid derivatives as nuclear transport modulators

, World Intellectual Property Organization, , ,

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Boron trifluoride etherate ; 30 min, 25 °C; 25 °C → 90 °C; 3 h, 90 °C; 90 °C → rt
1.2 Solvents: Water ; 30 min, cooled

参考文献：

Methods of promoting wound healing using CRM-1 inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Boron trifluoride etherate ; 30 min, 25 °C; 25 °C → 90 °C; 3 h, 90 °C; 3 h, 90 °C; 90 °C → rt
1.2 Solvents: Water ; 30 min, cooled

参考文献：

Preparation of hydrazide containing nuclear transport modulators and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Boron trifluoride etherate Solvents: Isopropanol ; 10 min, 25 °C; 25 °C → 90 °C; 2 h, 90 °C; 90 °C → 30 °C
1.2 Reagents: Water ; 0 °C

参考文献：

Preparation of N'-substituted pentafluorosulfanyltrifluoromethylphenyl-1H-1,2,4-triazolylacroylhydrazides as nuclear transport modulators

, World Intellectual Property Organization, , ,

合成路线：1 步

_61%

反应条件：

1.1 Reagents: Boron trifluoride etherate Solvents: Isopropanol ; 2 h, rt → 90 °C; 90 °C → rt
1.2 Reagents: Water ; cooled

参考文献：

Azole derivatives as nuclear transport modulators and their preparation and use in the treatment of diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_56%

反应条件：

1.1 Reagents: Isopropanol , Boron trifluoride etherate Solvents: Isopropanol

参考文献：

The stereochemistry of addition of trialkylammonium and pyridinium tetrafluoroborate salts to activated acetylenes. Preparation of novel dienophiles for Diels-Alder reactions

Jung, Michael E.; Buszek, Keith R., Journal of the American Chemical Society, 1988, 110(12), 3965-9

合成路线：1 步

_50%

反应条件：

1.1 Reagents: Boron trifluoride etherate ; 3 h, 90 °C

参考文献：

An unexpected Lewis acid catalyzed Diels-Alder cycloaddition of aryl allenes and acrylates

Conner, Michael L.; Brown, M. Kevin, Tetrahedron, 2016, 72(26), 3759-3765

合成路线：1 步

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane ; 0 °C; 2 h, 0 °C; 0 °C → 23 °C; 23 °C
1.2 Solvents: Ethyl acetate ; 1 h, 0 °C

参考文献：

One-Pot Synthesis of Chromone Fused-Pyrrolo[2,1-a]isoquinolines and Indolizino[8,7-b]indoles: Iodine Promoted Oxidative [2+2+1] Annulation of O-acetylphenoxyacrylates with Tetrahydroisoquinolines and Noreleagnines

Shang, Zhi-Hao; Zhang, Xiang-Jin; Li, Yi-Ming; Wu, Rui-Xue; Zhang, Hui-Ru; et al, Journal of Organic Chemistry, 2021, 86(21), 15733-15742

合成路线：1 步

反应条件：

1.1 Reagents: p-Toluenesulfonic acid Solvents: Isopropanol

参考文献：

Pyridine-Based Organocatalysts for Regioselective syn-1,2-Silaboration of Terminal Alkynes and Allenes

Morimasa, Yohei; Kabasawa, Kosuke; Ohmura, Toshimichi ; Suginome, Michinori, Asian Journal of Organic Chemistry, 2019, 8(7), 1092-1096

合成路线：1 步