96-30-0 (2-氯-N-甲基乙酰胺,2-Chloro-N-methylacetamide)

_100%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dichloromethane ; 1 h, rt; 1 h, rt; 70 min, reflux
1.2 Reagents: Water ; 15 min, rt

参考文献：

4-Arylthieno[2,3-b]pyridine-2-carboxamides are a new class of antiplasmodial agents

Schweda, Sandra I. ; Alder, Arne; Gilberger, Tim ; Kunick, Conrad, Molecules, 2020, 25(14),

合成路线：1 步

105-39-5

_98%

反应条件：

1.1 Solvents: Water ; 30 min, -5 °C
1.2 Solvents: Water ; < pH 5

参考文献：

preparation of N,N'-bis[2,3-dihydroxypropyl] -5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzene dicarboxamide

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Solvents: Water ; -15 °C; 5 h, -15 °C

参考文献：

Method for preparing O,O-dimethyl-S-(N-methylcarbamyl methyl)thiophosphate

, China, , ,

合成路线：1 步

96-34-4

_95%

反应条件：

1.1 Solvents: Methanol ; rt → -10 °C; -5 °C; 2 h, -5 °C

参考文献：

Synthesis of 14C-labeling omethoate

She, Dongmei; Qu, Zhe; Huang, Qiliang; Li, Fengmin, Henong Xuebao, 2006, 20(2), 162-163

合成路线：1 步

96-34-4

_92%

反应条件：

1.1 Solvents: Ethanol ; 10 - 15 min, -5 °C; 2.5 h, < 0 °C

参考文献：

Synthesis of N-methyl-2-[4-(4-chlorophenoxy)phenoxy]acetamide

Jiang, Yin; Wang, Hong; Gao, Yong-hong, Huaxue Shijie, 2009, 50(6), 364-366

合成路线：1 步

96-34-4

_92%

反应条件：

1.1 Solvents: Ethanol ; rt → -5 °C; 10 - 15 min, -5 °C; 2.5 h, < 0 °C; 0 °C → 85 °C

参考文献：

Synthesis of N-methyl-2-(4-phenoxyphenoxy)acetamide

Jin, Dongyuan; Tao, Jianwei; Kang, Liqin; Gao, Yonghong; He, Xiangqi, Jingxi Huagong, 2007, 24(9), 927-929

合成路线：1 步

593-51-1

_84%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Water ; 1 h, rt

参考文献：

Preparation of fused pyrimidines as glucose uptake inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_80%

反应条件：

1.1 Solvents: Water ; 15 min, 10 °C; 30 min, 10 °C

参考文献：

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands - A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

Elmehriki, Adam A. H.; Milne, Mark; Suchy, Mojmir; Bartha, Robert; Hudson, Robert H. E., Canadian Journal of Chemistry, 2013, 91(3), 211-219

合成路线：1 步

3926-62-3

593-51-1

_76%

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Acetonitrile , Water ; 30 min, rt

参考文献：

Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature

Tung, Truong Thanh; Nielsen, John, Organic & Biomolecular Chemistry, 2021, 19(46), 10073-10080

合成路线：1 步

_73%

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C; 0 °C → rt; 16 h, rt

参考文献：

Cyanoindoline derivatives as NIK inhibitors and their preparation

, World Intellectual Property Organization, , ,

合成路线：1 步

_58%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 0 °C; 24 h, 0 °C

参考文献：

Continuous-Flow Electrosynthesis of Benzofused S-Heterocycles by Dehydrogenative C-S Cross-Coupling

Huang, Chong; Qian, Xiang-Yang; Xu, Hai-Chao, Angewandte Chemie, 2019, 58(20), 6650-6653

合成路线：1 步

_48%

反应条件：

1.1 Solvents: Water ; -20 °C; 15 min, -20 °C → rt
1.2 Reagents: Hydrogen ion Solvents: Water ; pH 5

参考文献：

Preparation of quinoline derivatives as protein tyrosine kinase inhibitors

, China, , ,

合成路线：1 步

_37%

反应条件：

1.1 Solvents: Water ; -20 °C → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Indanylidenes. 1. Design and Synthesis of (E)-2-(4,6-Difluoro-1-indanylidene)acetamide, a Potent, Centrally Acting Muscle Relaxant with Antiinflammatory and Analgesic Activity

Musso, David L.; Cochran, Felicia R.; Kelley, James L.; McLean, Ed W.; Selph, Jeffrey L.; et al, Journal of Medicinal Chemistry, 2003, 46(3), 399-408

合成路线：1 步

_36%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Nitrogen and sulphur synthetic organic chemistry (MSc Thesis)

Harris, Philip, 1986, , ,

合成路线：1 步

_36%

反应条件：

1.1 Solvents: Water ; 0 °C; 0 °C → 10 °C; 10 °C

参考文献：

Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers

Wang, Zhao; Shi, Xuan-Hong; Wang, Jia; Zhou, Tian; Xu, You-Zhi; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(4), 1097-1101

合成路线：1 步

_27%

反应条件：

1.1 Solvents: Water ; -20 °C; -20 °C → 0 °C

参考文献：

An ATP-selective, lanthanide complex luminescent probe

Liu, Xiao; Xu, Jun; Lv, Yinyun; Wu, Wenyu; Liu, Weisheng; et al, Dalton Transactions, 2013, 42(27), 9840-9846

合成路线：1 步

_25%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Dichloromethane ; 20 min, -10 °C

参考文献：

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1

Zima, Vaclav; Albinana, Carlos Berenguer; Rojikova, Katerina; Pokorna, Jana; Pachl, Petr; et al, Bioorganic & Medicinal Chemistry, 2019, 27(13), 2935-2947

合成路线：1 步

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Acetonitrile ; 0 °C

参考文献：

A series of 1,2,3-triazole compounds: Synthesis, characterization, and investigation of the cholinesterase inhibitory properties via in vitro and in silico studies

Tan, Ayse ; Almaz, Zuleyha, Journal of Molecular Structure, 2023, 1277,

合成路线：1 步

反应条件：

1.1 Solvents: Dichloromethane , Tetrahydrofuran ; 2 h, 0 °C

参考文献：

Preparation of bicyclic bridged cycloalkane derivatives as ATF4 pathway inhibitors for the treatment of diseases

, World Intellectual Property Organization, , ,

合成路线：1 步