964-21-6 (Guanosine,2'-deoxy-6-O-methyl-,O6-Methyl-2’-deoxyguanosine)

快速询单

结构式：

Guanosine,2'-deoxy-6-O-methyl-MOL文件

CAS号：

964-21-6

中文名称：

Guanosine,2'-deoxy-6-O-methyl-

英文名称：

O6-Methyl-2’-deoxyguanosine

分子式：

C₁₁H₁₅N₅O₄

分子量：

281.267901659012

Guanosine,2'-deoxy-6-O-methyl-(964-21-6)名称与标识符

名称

英文别名：

Guanosine,2'-deoxy-6-O-methyl-;O6-METHYL-2’-DEOXYGUANOSINE;O6-METHYL-2'-DEOXYGUANOSINE;2-Amino-6-methoxy-2'-deoxy-6-deaminoadenosine;6-O-METHYL-2'-DEOXYGUANOSINE;O(6)-methyl-2'-deoxyguanosine;O6-methyl-2'-deoxy-guanosine;O6-methyldeoxyguanosine;2′-Deoxy-6-O-methylguanosine (ACI);9H-Purine, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxy- (8CI);D;9H-Purine, 2-amino-9-(2-deoxy-β-D-ribofuranosyl)-6-methoxy- (7CI);2-Amino-6-methoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine;2′-Deoxy-6-methylguanosine;6-O-Methyl-2′-deoxyguanosine;6-O-Methyldeoxyguanosine;O6-Methyl-2′-deoxyguanosine;O6-Methyl-dG;2'-Deoxy-N2-methyl-D-guanosine;DTXSID60242222;DA-70322;964-21-6;G76585;2-Amino-9-(2-deoxy-ss-D-erythro-pentofuranosyl)-6-methoxy-9H-purine; 2-Amino-9-(2-deoxy-ss-D-ribofuranosyl)-6-methoxy-9H-purine; 2'-Deoxy-6-O-methylguanosine; 2'-Deoxy-6-methylguanosine; 2-Amino-6-methoxy-9-(2-deoxy-ss-D-erythro-pentofuranosyl)purine;;BIDD:GT0852;Epitope ID:146099;(2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;Guanosine, 2'-deoxy-6-O-methyl-;O6-methyl-2 -deoxyguanosine;BCKDNMPYCIOBTA-RRKCRQDMSA-N;DTXCID60164713;C05031;9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methoxy-9H-purin-2-amine;SCHEMBL657819;J03;Q27103189;(2~{R},3~{S},5~{R})-5-(2-azanyl-6-methoxy-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;2-amino-6-methoxy-9-(2-deoxy-Beta-D-erythro-pentofuranosyl)purine;(2R,3S,5R)-5-(2-amino-6-methoxy-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;(2R,3S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;2'-Deoxy-O(6)-methylguanosine;(2R,3S,5R)-5-(2-amino-6-methoxypurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;CHEBI:27549;O6 -methyldeoxyguanosine;O(6)-Methyldeoxyguanosine;O6-Methyl-2-deoxyguanosine;

标识符

InChIKey：

BCKDNMPYCIOBTA-RRKCRQDMSA-N

Inchi：

1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+/m0/s1

SMILES：

O(C1N=C(N)N=C2N([C@H]3C[C@H](O)[C@@H](CO)O3)C=NC=12)C

Guanosine,2'-deoxy-6-O-methyl-(964-21-6)物化性质

实验特性

LogP : -0.36100
PSA : 128.54000

计算特性

精确分子量 : 281.11200
氢键供体数量 : 3
氢键受体数量 : 8
可旋转化学键数量 : 3
同位素质量 : 281.11240398g/mol
重原子数量 : 20
复杂度 : 349
同位素原子数量 : 0
确定原子立构中心数量 : 3
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 0.1
拓扑分子极性表面积 : 129Å²

Guanosine,2'-deoxy-6-O-methyl-(964-21-6)推荐厂家更多厂家(5)

公司名称	手机号/电话	联系人	QQ	询单
上海楷森生物科技有限公司	17558870519 175-58870519	赵经理	3003926540	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
上海甄准生物科技有限公司	13816009161 021-68920155	姜经理13816009161	3001086693	询单
杭州六可生物科技有限公司	15658003402 0086-571-86912261	Susan	3671025517	询单
上海源叶生物科技有限公司	15026964105 15026964105	汤思磊	2881489226	询单

Guanosine,2'-deoxy-6-O-methyl-(964-21-6)合成路线

合成路线：1 步

128790-76-1

_100%

964-21-6

反应条件：

1.1 Reagents: Triethylamine , 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Methanol

参考文献：

6-O-Substituted guanosine derivatives prepared by acylation and substitution reactions

, United States, , ,

合成路线：1 步

961-07-9

334-88-3

_79%

964-21-6

反应条件：

1.1 Solvents: Diethyl ether , Methanol ; 4 h, -20 °C

参考文献：

Preparation of nucleotide prodrugs and their use treating a mitochondrial DNA depletion syndrome

, World Intellectual Property Organization, , ,

合成路线：1 步

705255-09-0

67-56-1

_61%

964-21-6

反应条件：

1.1 Reagents: Dowex 1X2 Solvents: Methanol ; 27 h, rt

参考文献：

Functionalization of Guanosine and 2'-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole

Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J., Nucleosides, 2004, 23, 137-147

合成路线：1 步

961-07-9

_60%

964-21-6

反应条件：

1.1 Reagents: Trifluoroacetic anhydride Solvents: Pyridine
1.2 Reagents: Sodium methoxide Solvents: Methanol
1.3 Reagents: Pyridine , Hydrochloric acid

参考文献：

Synthesis of 6-substituted 2'-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

Fathi, Reza; Goswami, Bhaswati; Kung, Pei Pei; Gaffney, Barbara L.; Jones, Roger A., Tetrahedron Letters, 1990, 31(3), 319-22

合成路线：1 步

20535-83-5

14215-97-5

_37%

964-21-6

反应条件：

1.1 Reagents: N,O-Bis(trimethylsilyl)acetamide Catalysts: Trimethylsilyl triflate Solvents: Acetonitrile ; 5 min, 130 °C
1.2 Reagents: Triethanolamine Solvents: Acetonitrile , Water ; 30 min, rt
1.3 Reagents: Silica Solvents: Methanol , Dichloromethane ; rt
1.4 Reagents: Ammonia Solvents: Methanol ; 16 h, 50 °C
1.5 Reagents: Silica Solvents: Methanol , Dichloromethane ; rt

参考文献：

High-Throughput Five Minute Microwave Accelerated Glycosylation Approach to the Synthesis of Nucleoside Libraries

Bookser, Brett C.; Raffaele, Nicholas B., Journal of Organic Chemistry, 2007, 72(1), 173-179

合成路线：1 步

21561-99-9

961-07-9

_24%

964-21-6

反应条件：

1.1 Solvents: Methanol

参考文献：

N-Nitroso compounds. VII. Mechanism of nucleoside alkylation by alkylnitrosourea - reaction of 2'-deoxyguanosine with N-nitroso-N-methyl-N'-phenylurea in Methanol

Yoshida, Kitaro; Yano, Kazuyuki; Yano, Yumihiko, Nippon Kagaku Kaishi, 1996, (1), 100-3

合成路线：1 步

128790-76-1

124-41-4

964-21-6

参考文献：

Product class 17: purines

Seela, F.; Ramzaeva, N.; Rosemeyer, H., Science of Synthesis, 2004, 16, 945-1108

合成路线：1 步

31081-04-6

961-07-9

964-21-6

参考文献：

Detection of O6-Carboxymethyl-2'-deoxyguanosine in DNA Following Reaction of Nitric Oxide with Glycine and in Human Blood DNA Using a Quantitative Immunoslot Blot Assay

Cupid, Belinda C.; Zeng, Zuotao; Singh, Rajinder; Shuker, David E. G., Chemical Research in Toxicology, 2004, 17(3), 294-300

合成路线：1 步

128790-76-1

964-21-6

反应条件：

1.1 Reagents: Sodium methoxide

参考文献：

6-O-(Pentafluorophenyl)-2'-deoxyguanosine: a versatile synthon for nucleoside and oligonucleotide synthesis

Gao, Hetian; Fathi, Reza; Gaffney, Barbara L.; Goswami, Bhaswati; Kung, Pei Pei; et al, Journal of Organic Chemistry, 1992, 57(25), 6954-9

合成路线：1 步

964-21-6

参考文献：

Nucleotide prodrugs

, World Intellectual Property Organization, , ,

合成路线：1 步

964-21-6

参考文献：

Synthesis and Characterization of DNA Containing O6-Carboxymethylguanine

Xu, Y.-Z., Tetrahedron, 2000, 56(33), 6075-6081

合成路线：1 步

964-21-6

参考文献：

The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)

Golding, Bernard T.; Bleasdale, Christine; McGinnis, Joseph; Mueller, Susanna; Rees, Hue Thu; et al, Tetrahedron, 1997, 53(11), 4063-4082

合成路线：1 步

964-21-6

参考文献：

N7-DNA: synthesis and base pairing of oligonucleotides containing N7-(2-deoxy-β-D-erythro-pentofuranosyl)guanine (N7Gd)

Seela, Frank; Leonard, Peter, Helvetica Chimica Acta, 1996, 79(2), 477-87

合成路线：1 步

964-21-6

参考文献：

Synthesis of Oligodeoxyribonucleotides Containing Analogs of O6-Methylguanine and Reaction with O6-Alkylguanine-DNA Alkyltransferase

Spratt, Thomas E.; Campbell, Colin R., Biochemistry, 1994, 33(37), 11364-71

合成路线：1 步

964-21-6

参考文献：

Deacylation of 2-N-isobutyryl- and 2-N-isobutyryl-6-O-methyl-2'-deoxyguanosine in the condensed and gas phase. A kinetic investigation

Liguori, Angelo; Napoli, Anna; Siciliano, Carlo; Sindona, Giovanni, Journal of the Chemical Society, 1994, (8), 1833-8

合成路线：1 步

964-21-6

参考文献：

Solid-phase synthesis of oligodeoxynucleotides containing 6-O-alkylguanosines

Roelen, H. C. P. F.; Brugghe, H. F.; Van den Elst, H.; Klein, J. C.; Van der Marel, G. A.; et al, Recueil des Travaux Chimiques des Pays-Bas, 1992, 111(5), 227-34

合成路线：1 步

964-21-6

参考文献：

Preparation of O6-methyldeoxyguanosine monophosphate

Wang, Jujun, Huaxue Shiji, 1990, 12(2), 112-13

合成路线：1 步

964-21-6

参考文献：

A one step synthesis of O6-methyl-2'-deoxyguanosine

Bernadou, Jean; Blandin, Michel; Meunier, Bernard, Nucleosides & Nucleotides, 1983, 2(5), 459-64

合成路线：1 步

964-21-6